The DOI matches its Crossref record; 93 of the 93 references it cites were found in a registry or an index.
Major air pollutants and risk of COPD exacerbations: a systematic review and meta-analysis
Open accessAbstract
Background: Short-term exposure to major air pollutants (O 3 , CO, NO 2 , SO 2 , PM 10 , and PM 2.5 ) has been associated with respiratory risk. However, evidence on the risk of chronic obstructive pulmonary disease (COPD) exacerbations is still limited. The present study aimed at evaluating the associations between short-term exposure to major air pollutants and the risk of COPD exacerbations. Methods: After a systematic search up until March 30, 2016, in both English and Chinese electronic databases such as PubMed, EMBASE, and CNKI, the pooled relative risks and 95% confidence intervals were estimated by using the random-effects model. In addition, the population-attributable fractions (PAFs) were also calculated, and a subgroup analysis was conducted. Heterogeneity was assessed by I 2 . Results: In total, 59 studies were included. In the single-pollutant model, the risks of COPD were calculated by each 10 µg/m 3 increase in pollutant concentrations, with the exception of CO (100 µg/m 3 ). There was a significant association between short-term exposure and COPD exacerbation risk for all the gaseous and particulate pollutants. The associations were strongest at lag0 and lag3 for gaseous and particulate air pollutants, respectively. The subgroup analysis not only further confirmed the overall adverse effects but also reduced the heterogeneities obviously. When 100% exposure was assumed, PAFs ranged from 0.60% to 4.31%, depending on the pollutants. The adverse health effects of SO 2 and NO 2 exposure were more significant in low-/middle-income countries than in high-income countries: SO 2 , relative risk: 1.012 (95% confidence interval: 1.001, 1.023); and NO 2 , relative risk: 1.019 (95% confidence interval: 1.014, 1.024). Conclusion: Short-term exposure to air pollutants increases the burden of risk of COPD acute exacerbations significantly. Controlling ambient air pollution would provide benefits to COPD patients. Keywords: COPD exacerbations, air pollution, meta-analysis, acute exposure
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Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823
Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & the PRISMA Group* (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-151-4-200908180-00135 · Cited by 37,554
Dermyshi, E., Wang, Y., Yan, C., Hong, W., Qiu, G., Gong, X., & Zhang, T. (2017) · Neonatology · doi:10.1159/000454668 · Cited by 24,451
Meta-analysis of Observational Studies in Epidemiology<SUBTITLE>A Proposal for Reporting</SUBTITLE>
Stroup, D. F. (2000) · JAMA · doi:10.1001/jama.283.15.2008 · Cited by 20,623
Statistical Aspects of the Analysis of Data From Retrospective Studies of Disease
(1959) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/22.4.719 · Cited by 14,689 · cited 1×
“21 In order to explore the sources of heterogeneity, subgroup and meta-regression analyses were performed based on study design, population location, age, and outcome category.”
Fine Particulate Air Pollution and Hospital Admission for Cardiovascular and Respiratory Diseases
Dominici, F., Peng, R. D., Bell, M. L., Pham, L., McDermott, A., Zeger, S. L., & Samet, J. M. (2006) · JAMA · doi:10.1001/jama.295.10.1127 · Cited by 2,634
Investigating and dealing with publication and other biases in meta-analysis
Sterne, J. A. C., Egger, M., & Smith, G. D. (2001) · BMJ · doi:10.1136/bmj.323.7304.101 · Cited by 2,225
Occupational and Environmental Medicine: Meeting the Growing Need for Clinical Services
Rosenstock, L., Rest, K. M., Benson, J. A., Cannella, J. M., Cohen, J., Cullen, M. R., Davidoff, F., Landrigan, P. J., Reynolds, R. C., Clever, L. H., et al. (1991) · New England Journal of Medicine · doi:10.1056/nejm199109263251305 · Cited by 1,627
Respiratory effects are associated with the number of ultrafine particles.
Peters, A., Wichmann, H. E., Tuch, T., Heinrich, J., & Heyder, J. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.4.9105082 · Cited by 1,260
Journal of Epidemiology and Community Health
(1982) · International Journal of Epidemiology · doi:10.1093/ije/11.2.201 · Cited by 1,255
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Air pollution and its effects on the immune system
Glencross, D. A., Ho, T.-R., Camiña, N., Hawrylowicz, C. M., & Pfeffer, P. E. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.01.179 · Cited by 726
Coccia, M. (2020) · Science of The Total Environment · doi:10.1016/j.scitotenv.2020.138474 · Cited by 689
Outdoor air pollution, green space, and cancer incidence in Saxony: a semi-individual cohort study
Datzmann, T., Markevych, I., Trautmann, F., Heinrich, J., Schmitt, J., & Tesch, F. (2018) · BMC Public Health · doi:10.1186/s12889-018-5615-2 · Cited by 141
Metadata
- Authors
- Li, J., Sun, S., Tang, R., Qiu, H., Huang, Q., Mason, T., & Tian, L.
- Venue
- International Journal of Chronic Obstructive Pulmonary Disease
- Publisher
- Informa UK Limited
- Published
- 2016-12
- Volume
- Volume 11
- Pages
- 3079-3091
- ISSN
- 1176-9106 (ISSN-L)
- 1178-2005
- OpenAlex
- W2564702730
- Cited by
- 283
- References
- 93
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- gold
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- Li, J., Sun, S., Tang, R., Qiu, H., Huang, Q., Mason, T., & Tian, L. (2016). Major air pollutants and risk of COPD exacerbations: a systematic review and meta-analysis. International Journal of Chronic Obstructive Pulmonary Disease. https://doi.org/10.2147/copd.s122282
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