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Cited by 83Chronic Obstructive Pulmonary Disease (COPD) ResearchGenetic Associations and EpidemiologyAsthma and respiratory diseases

Genetic Polymorphism and Chronic Obstructive Pulmonary Disease

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Yuan, Cunhua, Chang, De, Lu, Guangming, Deng, Xiaowei·2017·International Journal of Chronic Obstructive Pulmonary Disease
DOI 10.2147/copd.s134161PMC PMC5436778
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Abstract

Chronic obstructive pulmonary disease (COPD) is a common chronic disease, and its morbidity and mortality are increasing. There are many studies that have tried to explain the pathogenesis of COPD from genetic susceptibility, to identify the susceptibility of COPD factors, which play a role in early prevention, early detection and the early treatment. However, it is well known that COPD is an inflammatory disease characterized by incomplete reversible airflow limitation in which genes interact with the environment. In recent years, many studies have proved gene polymorphisms and COPD correlation. However, there is less research on the relationship between COPD and genome-wide association study (GWAS), epigenetics and apoptosis. In this paper, we summarized the correlation between gene level and COPD from the following four aspects: the GWAS, the gene polymorphism, the epigenetics and the apoptosis, and the relationship between COPD and gene is summarized comprehensively.

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  • Identified polymorphisms include genes involved in functions that can favor skeletal muscle wasting, such as oxidative capacity (glutathione-S-transferase, superoxide dismutase) or inflammation (TNF-α).

    “Identified polymorphisms notably include genes involved in functions that can favor skeletal muscle wasting, such as oxidative capacity (glutathione-S-transferase, superoxide dismutase, etc.) or inflammation (TNF-α) [147].”

    From Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting (2023) · cites this paper as [147]

    The sections on glutathione S-transferase, superoxide dismutase, and tumor necrosis factor identify polymorphisms in oxidative–antioxidative and inflammatory pathways. The separate “Other pathogenesis of COPD” section discusses muscle mass loss, but does not link it to polymorphisms in those three genes. No page numbers are available in our copy. (LLM, conf=0.86)

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Authors
Yuan, C., Chang, D., Lu, G., & Deng, X.
Affiliations
  • Chinese People's Armed Police General Hospital (CN)
  • Chinese PLA General Hospital (CN)
Corresponding author
  • Chang, De
  • Lu, Guangming
ORCID
Venue
International Journal of Chronic Obstructive Pulmonary Disease
Publisher
Informa UK Limited
Published
2017-05
Volume
Volume 12
Pages
1385-1393
ISSN
  • 1176-9106 (ISSN-L)
  • 1178-2005
DOI
10.2147/copd.s134161
PMC
PMC5436778
OpenAlex
W2614068855
Cited by
83
References
0
Citations by year
2026: 1 · 2025: 3 · 2024: 5 · 2023: 11 · 2022: 12 · 2021: 15 · 2020: 25 · 2019: 4 · 2018: 7
FWCI
1.80
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of COPD (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
Funders
Beijing Nova Program (Z171100001117012)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
Keywords
chronic obstructive pulmonary disease, genetic polymorphism, genetic susceptibility, genome-wide association study, epigenetics, apoptosis, gene-environment interaction, COPD pathogenesis
MeSH terms
Genetic Markers, Humans, Lung, Phenotype, Risk Factors, Apoptosis, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Pulmonary Disease, Chronic Obstructive, Epigenesis, Genetic, Genome-Wide Association Study

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