Gut microbiota–derived short-chain fatty acids and kidney diseases
Open accessAbstract
Gut microbiota and its metabolites play pivotal roles in host physiology and pathology. Short-chain fatty acids (SCFAs), as a group of metabolites, exert positive regulatory effects on energy metabolism, hormone secretion, immune inflammation, hypertension, and cancer. The functions of SCFAs are related to their activation of transmembrane G protein-coupled receptors and their inhibition of histone acetylation. Though controversial, growing evidence suggests that SCFAs, which regulate inflammation, oxidative stress, and fibrosis, have been involved in kidney disease through the activation of the gut-kidney axis; however, the molecular relationship among gut microbiota-derived metabolites, signaling pathways, and kidney disease remains to be elucidated. This review will provide an overview of the physiology and functions of SCFAs in kidney disease.
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Microbial metabolites including folate, butyrate and acetate are cofactors and allosteric regulators of epigenetic processes such as DNA methylation, histone acetylation and RNA interference.
“Microbial metabolites including folate, butyrate and acetate are cofactors and allosteric regulators of epigenetic processes such as DNA methylation, histone acetylation and RNA interference190–192.”
From The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease (2018) · cites this paper as [192]
Available data suggest that epigenetic changes mediated by the gut microbiota are involved in the pathogenesis of dysbiosis-associated hypertension and chronic kidney disease.
“Together, the available data suggest that epigenetic changes mediated by the gut microbiota are involved in the pathogenesis of dysbiosis-associated hypertension and CKD.”
From The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease (2018) · cites this paper as [192]
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References 132 · Cited by 164
- Authors
- Li, L., Ma, L., & Fu, P.
- Affiliations
- West China Hospital of Sichuan University (CN)
- Corresponding author
- Ma, Liang
- Fu, Ping
- Venue
- Drug Design, Development and Therapy
- Publisher
- Informa UK Limited
- Published
- 2017-12
- Volume
- Volume 11
- Pages
- 3531-3542
- ISSN
- 1177-8881 (ISSN-L)
- PMC
- PMC5729884
- OpenAlex
- W2772686323
- Cited by
- 164
- References
- 132
- Citations by year
- 2026: 19 · 2025: 19 · 2024: 19 · 2023: 24 · 2022: 26 · 2021: 18 · 2020: 17 · 2019: 14 · 2018: 8
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Drug Design Development and Therapy (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Funders
- University of Michigan
- National Key Research and Development Program of China (2016YFC1305403)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Keywords
- short-chain fatty acids, gut microbiota, kidney disease, gut-kidney axis, G protein-coupled receptors, histone acetylation, inflammation, oxidative stress, fibrosis, energy metabolism, hypertension
- MeSH terms
- Gastrointestinal Microbiome, Acetylation, Fatty Acids, Volatile, Histones, Humans, Inflammation, Kidney Diseases, Receptors, G-Protein-Coupled
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