The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Diagnosis of Chest Wall Tuberculosis Using Fine Needle Aspiration: A Single-Center Experience
Open accessAbstract
Introduction: Minimally invasive diagnosis of chest wall tuberculosis remains a challenge. Fine needle aspiration (FNA) is a simple and safe method of sampling. However, previous studies have shown that conventional tuberculosis tests had poor diagnostic performance in the needle aspirates. With the popularization of molecular detection application, the value of FNA in the diagnosis of chest wall tuberculosis needs to be reevaluated. Methods: We retrospectively studied patients with suspected chest wall tuberculosis at admission who underwent FNA for diagnosis and reported the diagnostic efficacy of acid-fast bacilli smear, mycobacterial culture, cytology and Xpert MTB/RIF (GeneXpert) when testing FNA specimens. A composite reference standard (CRS) was used as the diagnostic gold standard for this study. Results: Among 89 included FNA specimens, acid-fast bacilli smear, mycobacterial culture, and GeneXpert were positive in 15 (16.85%), 23 (25.8%), and 61 (68.5%), respectively. Thirty-nine (43.8%) had cytologic features suggestive of tuberculosis. According to CRS, 75 (84.3%) cases were categorized as chest wall tuberculosis, 14 (15.7%) were not diagnosed with tuberculosis. Using CRS as the gold standard, acid-fast bacilli smear, mycobacterial culture, cytology and GeneXpert exhibited sensitivity of 20%, 30.7%, 52% and 81.3%, respectively. Specificity in these four tests was found to be 100%. Sensitivity of GeneXpert was significantly higher than that of smear, culture and cytology, X 2 =66.3, p < 0.001. Conclusion: GeneXpert achieved higher sensitivity as compared to cytology and conventional TB tests in the chest wall FNA specimens. The implementation of GeneXpert may increase the diagnostic efficacy of FNA in the diagnosis of chest wall TB. Keywords: chest wall tuberculosis, fine needle aspiration, Xpert MTB/RIF, cytology, culture
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“FNAC and the histopathological exam are commonly used, if not gold standard, diagnostic tools [29,31].”
From Head and Neck Tuberculosis: A Rare Diagnosis and the Role of Surgical Biopsy and Histopathological Evaluation in Extrapulmonary Disease (2025) · cites this paper as [31]
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Chen, Z.-K., Wu, Z., Ye, T., Lin, C.-Y., & Guo, X. (2025) · PLoS ONE · doi:10.1371/journal.pone.0321507 · Cited by 8
Mogoantă, C. A., Osman, A., Georgescu, A.-M., Mitroi, A. M., Busuioc, C. I., Tănase, I., Cioboată, R., Liliac, I. M., Cimpeanu, O. L., & Ciolofan, M. S. (2025) · Pathogens · doi:10.3390/pathogens14050479 · Cited by 2
“FNAC and the histopathological exam are commonly used, if not gold standard, diagnostic tools [29,31].”
Yan, Q.-H., Chi, J., Zhang, L., Xue, F., Cui, J., & Kong, H. L. (2023) · World Journal of Clinical Cases · doi:10.12998/wjcc.v11.i28.6698 · Cited by 1
Hutapea, R. R., & Lina, J. (2025) · Syntax Literate Jurnal Ilmiah Indonesia · doi:10.36418/syntax-literate.v10i9.61736
Talib, A. L., & Rashid, R. Y. R. (2025) · Iraqi journal of Medical Sciences · doi:10.22578/ijms.23.2.21
Metadata
- Authors
- Li, W., & Sha, W.
- Affiliations
- Tongji University (CN)
- Corresponding author
- Li, Wenting
- Sha, Wei
- ORCID
- Venue
- Infection and Drug Resistance
- Publisher
- Informa UK Limited
- Published
- 2023-04
- Volume
- Volume 16
- Pages
- 2281-2290
- ISSN
- 1178-6973 (ISSN-L)
- PMC
- PMC10122463
- OpenAlex
- W4366085009
- Cited by
- 3
- References
- 26
- Citations by year
- 2025: 2 · 2023: 1
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Infection and Drug Resistance (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Funders
- Shanghai Clinical Research Center (19MC1910800)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Infectious Diseases › Infectious Diseases and Tuberculosis
- Health Sciences › Medicine › Infectious Diseases › Diagnosis and treatment of tuberculosis
- Keywords
- chest wall tuberculosis, fine-needle aspiration, Xpert MTB/RIF, acid-fast bacilli smear, mycobacterial culture, cytology, diagnostic sensitivity, composite reference standard
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