Tracking stem cells with superparamagnetic iron oxide nanoparticles: perspectives and considerations
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Superparamagnetic iron oxide nanoparticles (SPIONs) have been used for diagnoses in biomedical applications, due to their unique properties and their apparent safety for humans. In general, SPIONs do not seem to produce cell damage, although their long-term in vivo effects continue to be investigated. The possibility of efficiently labeling cells with these magnetic nanoparticles has stimulated their use to noninvasively track cells by magnetic resonance imaging after transplantation. SPIONs are attracting increasing attention and are one of the preferred methods for cell labeling and tracking in preclinical and clinical studies. For clinical protocol approval of magnetic-labeled cell tracking, it is essential to expand our knowledge of the time course of SPIONs after cell incorporation and transplantation. This review focuses on the recent advances in tracking SPION-labeled stem cells, analyzing the possibilities and limitations of their use, not only focusing on myocardial infarction but also discussing other models.
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MSC are capable of differentiating into adipocytes, osteoblasts, chondrocytes, myoblasts and neuron-like cells, making them useful in regenerative medicine.
“Since MSC are capable of differentiating into a variety of other cells, including adipocytes, osteoblasts, chondrocytes, myoblasts and neuron-like cells, they are highly useful and often employed in regenerative medicine applications [264, 265].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [264]
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Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease
Lai, R. C., Chen, T. S., & Lim, S. K. (2011) · Regenerative Medicine · doi:10.2217/rme.11.35 · Cited by 553 · cited 1× · see citing works
“4 However, the difficulty of evaluating and determining the precise contribution of each mechanism involved in cell-based treatments is one of the obstacles to their approval for clinical use.”
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Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications
Dadfar, S. M., Roemhild, K., Drude, N. I., von Stillfried, S., Knüchel, R., Kiessling, F., & Lammers, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.005 · Cited by 1,181 · see citing works
- Authors
- Jasmin, Souza, G. T., Andrade Louzada, R., Rosado-de-Castro, P. H., Mendez-Otero, R., & Carvalho, A. C. C.
- Affiliations
- Universidade Federal de Juiz de Fora (BR)
- Universidade Federal do Rio de Janeiro (BR)
- ORCID
- Venue
- International Journal of Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2017-01
- Volume
- Volume 12
- Pages
- 779-793
- ISSN
- 1176-9114 (ISSN-L)
- 1178-2013
- PMC
- PMC5279820
- OpenAlex
- W2580356729
- Cited by
- 78
- References
- 1
- Citations by year
- 2025: 5 · 2024: 9 · 2023: 10 · 2022: 8 · 2021: 14 · 2020: 10 · 2019: 9 · 2018: 8 · 2017: 5
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Nanomedicine (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- superparamagnetic iron oxide nanoparticles, stem cell tracking, cell labeling, magnetic resonance imaging, cell transplantation, myocardial infarction, nanoparticle biocompatibility, cell therapy
- MeSH terms
- Animals, Humans, Magnetic Resonance Imaging, Stem Cells, Magnetite Nanoparticles, Cell Tracking
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