The DOI matches its Crossref record; 196 of the 198 references it cites were found in a registry or an index.
Toxicity of Carbon Nanotubes as Anti-Tumor Drug Carriers
Open accessAbstract
Nanoparticle drug formulations have enormous application prospects owing to achievement of targeted and sustained release drug delivery, improvement in drug solubility and reduction of adverse drug reactions. Recently, a variety of efficient drug nanometer carriers have been developed, among which carbon nanotubes (CNT) have been increasingly utilized in the field of cancer therapy. However, these nanotubes exert various toxic effects on the body due to their unique physical and chemical properties. CNT-induced toxicity is related to surface modification, degree of aggregation in vivo, and nanoparticle concentration. This review has focused on the potential toxic effects of CNTs utilized as anti-tumor drug carriers. The main modes by which CNTs enter target sites, the toxicity expressive types and the factors affecting toxicity are discussed.
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Metadata
- Authors
- Yan, H., Xue, Z., Xie, J., Dong, Y., Ma, Z., Sun, X., Kebebe Borga, D., Liu, Z., & Li, J.
- Affiliations
- Tianjin University of Traditional Chinese Medicine (CN)
- Corresponding author
- Liu, Zhidong
- Venue
- International Journal of Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2019-12
- Volume
- Volume 14
- Pages
- 10179-10194
- ISSN
- 1176-9114 (ISSN-L)
- 1178-2013
- PMC
- PMC6946632
- OpenAlex
- W2997737850
- Cited by
- 113
- References
- 198
- Citations by year
- 2026: 11 · 2025: 18 · 2024: 25 · 2023: 17 · 2022: 18 · 2021: 19 · 2020: 4
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Nanomedicine (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Graphene and Nanomaterials Applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- carbon nanotubes, nanoparticle toxicity, nanoparticle drug delivery, cancer therapy, surface modification, nanoparticle aggregation, toxicity factors, targeted drug delivery
- MeSH terms
- Animals, Antineoplastic Agents, Drug Carriers, Humans, Solubility, Nanotubes, Carbon
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