The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Knee osteoarthritis: pathophysiology and current treatment modalities
Open accessAbstract
For decades, multiple attempts to fully understand knee osteoarthritis pathophysiology and natural history have been attempted. Despite the extensive amount of research regarding this topic, there are still marked controversies. This multifactorial condition gets influenced by local, systemic, and external factors and its progression and/or response to treatments widely varies from patient to patient. Multiple therapies have been studied in the past, low impact physical activity seems to be supported by all the current medical societies while other interventions have shown conflicting findings. Newer therapies and routes of administration are under investigation and some of them have shown promising preliminary reports. This review intends to give an overview of the current knowledge of pathophysiology and non-surgical therapies available for knee osteoarthritis.
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Cites
Radiological Assessment of Osteo-Arthrosis
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OARSI guidelines for the non-surgical management of knee osteoarthritis
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The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis
Sellam, J., & Berenbaum, F. (2010) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2010.159 · Cited by 1,500
Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis
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The mechanics of the knee joint in relation to normal walking
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“25,26 If a patient is refractory to other treatments and the use of an opioid is considered, Tramadol, a serotonin and norepinephrine reuptake inhibitor with weak µ opioid receptor agonist properties, has shown some benefit in the treatment of severe and moderate OA.”
Weight Loss Reduces the Risk for Symptomatic Knee Osteoarthritis in Women: The Framingham Study
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Metadata
- Authors
- Mora, J. C., Przkora, R., & Cruz-Almeida, Y.
- Venue
- Journal of Pain Research
- Publisher
- Informa UK Limited
- Published
- 2018-10
- Volume
- Volume 11
- Pages
- 2189-2196
- ISSN
- 1178-7090 (ISSN-L)
- OpenAlex
- W2894885260
- Cited by
- 574
- References
- 55
- FWCI
- 31.19
- Type
- journal article
- Language
- en
- Open access
- gold
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- Mora, J. C., Przkora, R., & Cruz-Almeida, Y. (2018). Knee osteoarthritis: pathophysiology and current treatment modalities. Journal of Pain Research. https://doi.org/10.2147/jpr.s154002
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
