Coprescribing proton-pump inhibitors with nonsteroidal anti-inflammatory drugs: risks versus benefits
Open accessAbstract
Nonsteroidal anti-inflammatory drugs (NSAIDs) are often coadministered with proton-pump inhibitors (PPIs) to reduce NSAID-induced gastrointestinal (GI) adverse events. This coadministration is generally regarded as safe, and is included in many of the guidelines on NSAID prescription. However, recent evidence indicates that the GI risks associated with NSAIDs can be potentiated when they are combined with PPIs. This review discusses the GI effects and complications of NSAIDs and how PPIs may potentiate these effects, options for prevention of GI side effects, and appropriate use of PPIs in combination with NSAIDs.
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PPIs have also been reported to exacerbate the mucosal damage caused by NSAIDs in the distal portion of the small bowel to the ligament of Treitz.
“PPIs have also been reported to exacerbate the mucosal damage caused by non-steroidal anti-inflammatory drugs (NSAIDs) in the distal portion of the small bowel to the ligament of Treitz[95,96]”
From Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified (2019) · cites this paper as [96]
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References 116 · Cited by 117
Research works printed but not linked: 1
- [79]National Institute for Health and Care Excellence Gastro-oesophageal Reflux Disease and Dyspepsia in Adults: Investigation and Management London NICE 2014 31935049
- Authors
- Gwee, K.-A., Goh, V., Lima, G., & Setia, S.
- Affiliations
- Gleneagles Hospital (SG)
- National University of Singapore (SG)
- Pfizer (Hong Kong) (HK)
- Corresponding author
- Setia, Sajita
- Venue
- Journal of Pain Research
- Publisher
- Informa UK Limited
- Published
- 2018-02
- Volume
- Volume 11
- Pages
- 361-374
- ISSN
- 1178-7090 (ISSN-L)
- PMC
- PMC5817415
- OpenAlex
- W2791120196
- Cited by
- 117
- References
- 116
- Citations by year
- 2026: 13 · 2025: 20 · 2024: 14 · 2023: 13 · 2022: 18 · 2021: 16 · 2020: 10 · 2019: 7 · 2018: 5
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Pain Research (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (acceptedVersion)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Funders
- Pfizer
- Topics
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Keywords
- proton pump inhibitors, nonsteroidal anti-inflammatory drugs, gastrointestinal adverse effects, NSAID-induced gastrointestinal complications, drug interactions, risk-benefit assessment
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