APOLLO-1: a randomized placebo and active-controlled phase III study investigating oliceridine (TRV130), a G protein-biased ligand at the µ-opioid receptor, for management of moderate-to-severe acute pain following bunionectomy

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Items 101–169 of 169

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3. The effects of oliceridine and sufentanil on postoperative nausea and vomiting in abdominal surgery (EOSPONVAS): protocol for a multicentre, two-arm, randomised controlled trial
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4. Biased Agonism: The Future (and Present) of Inotropic Support
   Huw Garland, Alain Vuylsteke · 2020 · Journal of Cardiothoracic and Vascular Anesthesia
5. Comparison of Oliceridine and Morphine in Postoperative Analgesia in Laparoscopic Total Hysterectomy, a Randomized Double-Blind Controlled Trial
   Jinjuan Duan, Xing Wang, Chengjing Hou, Tong Yu, Xia Ju, Shengbin Wang · 2025 · Drug Design Development and Therapy
6. Comparison of oliceridine and fentanyl intraoperative analgesia on postoperative nausea and vomiting in female patients undergoing laparoscopic cholecystectomy: study protocol for a randomized, double-blind, controlled trial
   Fangsheng Xu, Yuanyuan Cui, Zhengle Wang, Feng Wu, Wei Zhang, Rongguang Liu, Yuan Xu, Jian Tang, Jianfeng Pu, Meifang Wang · 2025 · Trials
7. Comparison of Postoperative Analgesic Efficacy of Oliceridine and Sufentanil in Total Laparoscopy Hysterectomy, a Clinical Double-Blind Controlled Trial
   Jinjuan Duan, Ning Liu, Qianlong Lu, Wu Gao, Chengjing Hou, Hongliang Liu, Yao Lu, Siqi Xu · 2026 · Drug Design Development and Therapy
8. In Vitro Effects of Ligand Bias on Primate Mu Opioid Receptor Downstream Signaling
   Xiao Zhang, Shaurita Hutchins, Bruce E. Blough, Eric J. Vallender · 2020 · International Journal of Molecular Sciences
9. Biased Opioid Ligands: Revolution or Evolution?
   Florence Noble, Nicolas Marie · 2021 · Frontiers in Pain Research
10. CYX-5, a G-protein biassed MOP receptor agonist, DOP receptor antagonist and KOP receptor agonist, evokes constipation but not respiratory depression relative to morphine in rats
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12. Synthesis and Biological Evaluation of Novel Biased Mu-Opioid Receptor Agonists
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13. New analgesics in cancer pain
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14. Opioids, stress and addiction: From stress-induced analgesia to opioid heterodimers with extraordinary analgesic efficacy and without the side effects of traditional opioids
    Giuseppe Cataldo, Donald A. Simone, Richard J. Bodnar · 2024 · Addiction Neuroscience
15. Differential inhibition of the diverse behavioural effects of mu-opioid receptor agonists by progressive receptor depletion
    Lauren Brown, Cory B. Langreck, Frances G Hough, Mel Nelson, Stephen J. Briddon, J. Robert Lane, Jonathan A. Javitch, Meritxell Canals · 2026 · Neuropharmacology
16. Nausea and vomiting as adverse events of oliceridine: a systematic review and meta-analysis of randomized controlled trials
    Jinfang Zeng, Shu Yang, Jinjin Jian, Minmin Zhu · 2026 · Frontiers in Pharmacology
17. Oliceridine (TRV130): a biased agonist of the μ opioid receptor as a novel analgesic
    Huan Wang, Huiqiong Li, Jianjun Cheng · 2024 · Elsevier eBooks
18. Pharmacological Diversity in Opioid Analgesics: Lessons From Clinically Useful Drugs
    Agnes Acevedo‐Canabal, Fani Pantouli, Akshaya Ravichandran, Laura Rullo, Laura Bohn · 2021 · Elsevier eBooks
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20. Opioid MOP receptor agonists in late-stage development for the treatment of postoperative pain
    Qiu Qiu, Joshua C. J. Chew, Michael G. Irwin · 2022 · Expert Opinion on Pharmacotherapy
21. Biased Agonism: Renewing GPCR’s Targetability for the Drug Discovery
    Ravinder Reddy Gaddam, Ajit Vikram · 2021 · Springer eBooks
22. Update on the Opioid Crisis
    Susan M. Kleppin · 2020 · Journal of Infusion Nursing
23. Determining the Effective Dose of Oliceridine Compounded with Propofol for Painless Hysteroscopy: A Prospective Modified Dixon Sequential Dose-Finding Study
    Ke Yang, Qian Yuan, Hao Huang, Lina Wang, Jingyu You, Qiaojie Liu, Yulin Zhou, Yi Luo, Qin Liu · 2025 · Journal of Pain Research
24. Effect of oliceridine versus morphine on the quality of early recovery after thoracoscopic surgery: a randomized, controlled clinical trial
    Xueqing Na, Ying Chen, Xin Liu, Jian Yang, Miao Tan, Yun Zhou, Man Shi, Jie Ouyang, Yongyu Si · 2026 · BMC Anesthesiology
25. EC50 of Remifentanil for Inhibiting Cardiovascular Responses to Tracheal Intubation in Patients Treated by Different Doses of Oliceridine: A Randomized Controlled Trial Using Up-and-Down Sequential Allocation Methodology
    Zhenzhen Zhao, Lingling Ge, Xiaolin Wang, Xiandong Wang, Jie Huang, Yaqin Xiao, Ying Zhang, Yan Zhou, Rui Bao, Jia-Feng Wang · 2026 · Drug Design Development and Therapy
26. Heteromerization, Biased Agonism, and Allosteric Modulation of G Protein‐Coupled Receptors in Addiction: Mechanistic Insights and Therapeutic Implications
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27. The Effect of Oliceridine Versus Sufentanil on the Quality of Postoperative Recovery in Patients Undergoing Laparoscopic Cholecystectomy
    Li-Hao Rao, Yang Ze-xue, Lun Huang, Li-Dong Zheng · 2026 · Journal of Pain Research
28. Effect of Propofol Combined with Oliceridine versus Fentanyl on Desaturation During Gastrointestinal Endoscopy: A Randomized Clinical Trial
    Fangsheng Xu, Yuanyuan Cui, Qian Wang, Jian Tang, Yuan Xu, Rongguang Liu, Zhengle Wang, Wei Zhang, Feng Wu, Shuyu Ma et al. · 2026 · Drug Design Development and Therapy
29. Multimodal Conscious Analgesia with Oliceridine and Alfentanil Plus Local Anesthesia in Revisional Upper Eyelid Blepharoplasty: A Multicenter Randomized Clinical Trial
    Yang Hu, Xiangyu Chen, Yuxing Wang, Chengwu Zhang, Shiyi Wen, Ziqiang Zhou, Xianrui Wu, Xin He, Jianda Zhou, Ping Li · 2026 · Aesthetic Plastic Surgery
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31. Perioperative Pain Management
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32. Airway effects of anaesthetics and anaesthetic adjuncts: What's new on the horizon?
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33. New pharmacological strategies for analgesic drug development: focus on biased m opioid receptor agonists
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34. Oliceridine — a unique drug among opioid analgesics
    Ewa Gibuła‐Tarłowska, Magdalena Burat, Ewa Kędzierska · 2020 · Journal of Medical Science
35. Caractéristiques pharmacologiques des antalgiques utilisables en situations sanitaires exceptionnelles
    Alain Eschalier · 2021 · Médecine de Catastrophe - Urgences Collectives
36. Clathrin regulates the β-arrestin pathway regardless of ligand bias
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37. Nuevos opioides con diferente mecanismo de acción intracelular; ¿una nueva ventana terapéutica se abre ante nosotros?
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38. Oliceridine
    Brittany M. Craft, Danial E. Baker · 2021 · Hospital Pharmacy
39. Journey of Oliceridine
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40. Clathrin regulates the β-arrestin pathway regardless of ligand bias
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41. Analgetika
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42. General Principles of Perioperative Pain Management
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43. Efficacy and safety of anrikefon injection for postoperative analgesia in specific patient groups (elderly, liver damage, renal damage) after abdominal surgery
    Younian Xu, Tianhao Zhang, Xin Huang, Sanawaer Tuerhong, Xiangdong Chen · 2024 · Journal of Anesthesia and Translational Medicine
44. Opioid analgesics for sedation-based gastrointestinal endoscopy
    Weilin Yang, Xinyu Zhou, Wencai Jiang, Xian-Jie Zhang, Dan Zhou · 2025 · World Journal of Gastrointestinal Pharmacology and Therapeutics
45. The median effective dose of esketamine with different doses of oliceridine during hysteroscopic surgery
    Min Yan Shi, Tong Wang, Weiwei Wang, Jiafeng Wang, Lulu Li, Lulong Bo, Xiaolin Wang · 2025 · Frontiers in Pharmacology
46. To Be Biased or Not to Be: A Play for G-Protein Coupled Receptors
    Nikitas G. Liolitsas, Evangelia Pantazaka, Εvangelia Papadimitriou · 2025 · International Journal of Translational Medicine
47. Knowledge graph and emerging trends in β-arrestin research on pain: a bibliometric analysis (1997–2025)
    Haifang Yu, Xuehai Ding, Yiqiang Zhang, Yuanyuan Yu, Xiaoli Wang · 2026 · Naunyn-Schmiedeberg s Archives of Pharmacology
48. Advances in Biased Opioid Agonists for Analgesia: Side Effects Minimisation and Addiction Prevention
    Kaiyun Zhang · 2025 · International Journal of Public Health and Medical Research
49. Research Progress on Biased Signaling of G Protein-Coupled Receptors and Their Downstream Pathway Network Interactions in the Skin and Immune System
    裕添 马 · 2026 · Pharmacy Information
50. A randomized double-blind placebo-controlled trial of oliceridine, a G protein-biased ligand at the µ-opioid receptor, for management of moderate-to-severe acute pain following bunionectomy
    Sunghoo Kim, B. -K. Cho, Ki-Won Young, Ki-Sun Sung, Young Koo Lee, Jiyong Ahn, Bom Soo Kim, Chan Kang, Keun‐Bae Lee, Chul Hyun Park et al. · 2026 · Current Medical Research and Opinion
51. Oliceridine for Analgesia in Elderly Patients Undergoing Kyphoplasty: From a Clinical Trial
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52. The ED90 of Oliceridine for Tracheal Intubation in Children: A Biased-Coin Up-and-Down Parallel Dose-Finding Study
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56. Oliceridine in the Prevention of Catheter-Related Bladder Discomfort: A Single-Center, Randomized, Double-Blind, Prospective Trial
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58. Duration of clinically meaningful improvement in pain as a patient-centered endpoint in acute pain trials
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59. Functionally selective (biased) mu-opiate receptor agonists approved for the management of acute pain. To be continued?
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61. Efficacy and safety of oliceridine versus sufentanil in perioperative anesthesia and analgesia: a systematic review and meta-analysis with trial sequential analysis
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62. Efficacy and safety of oliceridine versus sufentanil for patient-controlled intravenous analgesia following gynecological laparoscopic surgery: a randomized, double-blind, parallel-group trial
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68. BindingDB Entry 50016423: Analgesic Opioid Ligand Discovery Based on Nonmorphinan Scaffolds Derived from Natural Sources.
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