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Antioxidant and Antihyperglycemic Activity of Arthrospira platensis (Spirulina platensis) Methanolic Extract: In vitro and In vivo Study
Open accessAbstract
THE STUDY evaluated different extracts of Spirulina platensis using acetone, methanol, ethanol as well as water solvents for their antioxidant and antidiabetic potential. The results showed that all S. platensis extracts exhibited antioxidant activity by using DPPH (2, 2-Diphenyl-1-picrylhydrazyl), reducing power and total antioxidant capacity assays; in addition to their antidiabetic activity which was dependent on the used solvent. Among the tested extracts, S. platensis methanolic extract exhibited the highest antioxidant activity for all the tested assays and the maximum inhibitory effects for α-amylase (96.46 %) and α-glucosidase (97.42 %) diabetic enzymes. Spirulina methanolic extract showed no toxicity on normal cell lines using MTT assay. Gas chromatography–mass spectrometry (GC-MS) analysis of the methanolic extract revealed the presence of different bioactive compounds mainly phytol, 1-monolinoleoylglycerol trimethylsilyl ether, cholestan-3-ol, 2-methylene- (3β,5α) and fatty acids. These compounds might be acted synergistically to exert their obtained antioxidant and antidiabetic activity. For the in vivo study, administration of S. platensis methanolic extract (at 15 and 10 mg/Kg body weight (BW) caused antihyperglycemic activity by reducing the elevated blood glucose level. A remarkable decrease in different liver, kidney functions and hyperlipidemia related to diabetes were also detected. Furthermore, the methanolic extract treatment increased the body weight, total protein, albumin and hemoglobin levels as compared with the alloxan induced diabetic rats. Furthermore, treatment of diabetic rats with the extract improved liver and pancreas histopathological disorders related to diabetes. These results recommended using S. platensis methanolic extract in developing medicinal preparations for treatment of diabetes and its related symptoms.
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The methanolic extract of S. platensis contains bioactive compounds including phytols, phenolic compounds, and methyl esters of fatty acids, as found by GC-MS.
“Gheda et al. [55] found the presence of a variety of bioactive compounds when they conducted an analysis of the methanolic extract of S. platensis using GC-MS. These bioactive compounds included phytols, phenolic compounds, and methyl esters of fatty acids.”
From Trends and Technological Advancements in the Possible Food Applications of Spirulina and Their Health Benefits: A Review. (2022) · cites this paper as [55]
Diabetic rats given an aqueous extract of spirulina for fifty days showed a considerable rise in body weight, total protein, albumin, and hemoglobin levels, while untreated diabetic animals lost weight.
“A considerable rise in body weight, total protein, albumin, and hemoglobin levels were seen in diabetic rats after they were given an aqueous extract of spirulina to consume for a period of fifty days. This points to an improvement in general health conditions as well as metabolic mechanisms brought about by efficient glycemic management. On the other hand, the weight of diabetic animals that were”
From Trends and Technological Advancements in the Possible Food Applications of Spirulina and Their Health Benefits: A Review. (2022) · cites this paper as [55]
These bioactive compounds work synergistically to give spirulina antioxidant effects and the ability to decrease cholesterol and blood sugar levels.
“These bioactive compounds worked together to produce a synergistic effect. These are what give spirulina its antioxidant effects, as well as its ability to decrease cholesterol and blood sugar levels.”
From Trends and Technological Advancements in the Possible Food Applications of Spirulina and Their Health Benefits: A Review. (2022) · cites this paper as [55]
Administering the methanolic extract of spirulina to experimental mice at doses of 15 and 10 mg/kg body weight resulted in hypoglycemic activity and improved histological disorders of the liver and pancreas associated with diabetes.
“In addition, it was realized that administering the methanolic extract to experimental mice at doses of 15 and 10 mg/kg body weight resulted in hypoglycemic activity and improved the histological disorders of the liver and pancreas that are associated with diabetes.”
From Trends and Technological Advancements in the Possible Food Applications of Spirulina and Their Health Benefits: A Review. (2022) · cites this paper as [55]
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References 80 · Cited by 31
Metadata
- Authors
- Gheda, S. F., Abo-Shady, A. M., Abdel-Karim, O. H., & Ismail, G. A.
- Affiliations
- Tanta University (EG)
- Corresponding author
- Gheda, Saly F.
- Venue
- Egyptian Journal of Botany
- Published
- 2020-09-21
- Volume
- 0
- Issue
- 0
- Pages
- 0-0
- ISSN
- 0375-9237 (ISSN-L)
- 2357-0350
- OpenAlex
- W3088083974
- Cited by
- 31
- References
- 80
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 10 · 2023: 8 · 2022: 3 · 2021: 2
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Egyptian Journal of Botany (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- Spirulina platensis, methanol extract, antioxidant activity, antidiabetic activity, α-amylase inhibition, α-glucosidase inhibition, solvent extraction, phytol, fatty acids, alloxan-induced diabetes, hyperlipidemia, liver and kidney function, blood glucose
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