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Sex Differences in Pharmacokinetics and Pharmacodynamics
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“Many drugs aiming to cure or mediate disease have been pulled from the market due to unforeseen issues arising in one sex or another [50, 51].”
From Alzheimer’s disease-associated protective variant Plcg2-P522R modulates peripheral macrophage function in a sex-dimorphic manner (2024) · cites this paper as [50]
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“Moreover, results are not always analyzed by sex.”
From Sex Differences in Traumatic Brain Injury: What We Know and What We Should Know (2019) · cites this paper as [22]
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Metadata
- Authors
- Soldin, O. P., & Mattison, D. R.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Soldin, Offie P.
- Venue
- Clinical Pharmacokinetics
- Published
- 2009
- Volume
- 48
- Issue
- 3
- Pages
- 143-157
- ISSN
- 0312-5963 (ISSN-L)
- PMC
- PMC3644551
- OpenAlex
- W2017331060
- Cited by
- 1,163
- References
- 133
- Citations by year
- 2026: 111 · 2025: 136 · 2024: 133 · 2023: 127 · 2022: 119 · 2021: 109 · 2020: 95 · 2019: 67 · 2018: 57 · 2017: 53 · 2016: 31 · 2015: 23 · 2014: 24 · 2013: 27 · 2012: 16
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical Pharmacokinetics (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Center for Research Resources (M01RR023942)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (5U10HD047890-S, U10HD047890)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Keywords
- sex differences, pharmacokinetics, pharmacodynamics, pregnancy, drug absorption, drug distribution, drug metabolism, drug elimination, dosing regimen, therapeutic monitoring, drug safety, drug prescribing
- MeSH terms
- Biological Availability, Body Weight, Clinical Trials as Topic, Pharmaceutical Preparations, Female, Humans, Male, Menstrual Cycle, Pharmacokinetics, Pharmacology, Pregnancy, Sex Factors, Tissue Distribution, United States, United States Food and Drug Administration, Body Fat Distribution
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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