Economic Evaluation of Policy Options for Prevention and Control of Cervical Cancer in Thailand
Abstract
Background The Thai healthcare setting has seen patients with cervical cancer experience an increasing burden of morbidity and mortality, a stagnation in the performance of cervical screening programmes and the introduction of a vaccine for the prevention of human papillomavirus (HPV) infection. Objective This study aims to identify the optimum mix of interventions that are cost effective, from societal and healthcare provider perspectives, for the prevention and control of cervical cancer. Methods A computer-based Markov model of the natural history of cervical cancer was used to simulate an age-stratified cohort of women in Thailand. The strategy comparators, including both control and prevention programmes, were (i) conventional cytology screening (Pap smears); (ii) screening by visual inspection with acetic acid (VIA); and (iii) HPV-16, -18 vaccination. Input parameters (e.g. age-specific incidence of HPV infection, progression and regression of the infection, test performance of screening methods and efficacy of vaccine) were synthesized from a systematic review and meta-analysis. Costs (year 2007 values) and outcomes were evaluated separately, and compared for each combination. The screening strategies were started from the age of 30-40 years and repeated at 5- and 10-year intervals. In addition, HPV vaccines were introduced at age 15-60 years. Results All of the screening strategies showed certain benefits due to a decreased number of women developing cervical cancer v…
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The Markov model was based on previously published and validated models for cervical cancer.
“Based on the previously published and validated models for cervical cancer, we developed a markov model on MS Excel spread sheet, considering the natural history of HPV infection and cervical cancer (Fig 1). [12–15]”
From Cost effectiveness of strategies for cervical cancer prevention in India (2020) · cites this paper as [13]
These estimates have also been used to parameterize models to evaluate cervical cancer prevention strategies in Thailand, United Kingdom and Germany.
“These estimates have also been used to parameterize models to evaluate cervical cancer prevention strategies in Thailand, United Kingdom and Germany. [13–15]”
From Cost effectiveness of strategies for cervical cancer prevention in India (2020) · cites this paper as [13]
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References 36 · Cited by 79
- Authors
- Praditsitthikorn, N., Teerawattananon, Y., Tantivess, S., Limwattananon, S., Riewpaiboon, A., Chichareon, S., Ieumwananonthachai, N., & Tangcharoensathien, V.
- Affiliations
- Ministry of Public Health (TH)
- Mahidol University (TH)
- Prince of Songkla University (TH)
- Siriraj Hospital (TH)
- Corresponding author
- Praditsitthikorn, Naiyana
- ORCID
- Venue
- PharmacoEconomics
- Published
- 2011-09
- Volume
- 29
- Issue
- 9
- Pages
- 781-806
- ISSN
- 1170-7690 (ISSN-L)
- OpenAlex
- W2071321169
- Cited by
- 79
- References
- 36
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 12 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 11 · 2016: 6 · 2015: 9 · 2014: 7 · 2013: 9 · 2012: 3
- FWCI
- 4.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- PharmacoEconomics (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- World Bank Group
- Topics
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Women's cancer prevention and management
- Keywords
- cervical cancer prevention, cost-effectiveness, cervical cancer screening, Pap smear, visual inspection with acetic acid, HPV vaccination, Markov model, Thailand, quality-adjusted life years, incremental cost-effectiveness ratio, cervical cancer incidence and mortality
- MeSH terms
- Adolescent, Adult, Uterine Cervical Neoplasms, Cost-Benefit Analysis, Female, Health Policy, Humans, Markov Chains, Mass Screening, Middle Aged, Thailand, Vaginal Smears, Models, Economic, Quality-Adjusted Life Years, Acetic Acid, Papillomavirus Infections, Papillomavirus Vaccines, Young Adult, Papanicolaou Test
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