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Alpha1-Antichymotrypsin Level in Cerebrospinal Fluid Is Closely Associated with Late Onset Alzheimer's Disease.
Open accessAbstract
The levels of alpha 1-antichymotrypsin (ACT) in cerebrospinal fluid (CSF) from 66 sporadic Alzheimer's disease (AD) patients and 54 normal controls were measured by enzyme immunoassay and compared. There was no correlation (r = 0.259, n = 54) between the ACT level and normal aging. The levels of ACT were significantly higher in the total AD group (p < 0.01) than in the normal control group. Dividing AD patients into early onset AD (n = 27) and late onset AD groups (n = 39), the mean level of CSF ACT in the late onset AD group was significantly higher than that in the normal control group (p < 0.001) and that in the early onset AD group (p < 0.01). Thus, the level of ACT in CSF is closely associated with late onset AD.
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Serpina3n, a gene known to be associated with AD risk, was increased in Abi3−/− mice.
“We observed an increase in Serpina3n, a gene that is known to be associated with AD risk (30), in Abi3−/− mice.”
From Deletion of Abi3 gene locus exacerbates neuropathological features of Alzheimer’s disease in a mouse model of Aβ amyloidosis (2021) · cites this paper as [30]
The Results (page not provided) show that cerebrospinal-fluid alpha1-antichymotrypsin levels were elevated in patients with late-onset AD, supporting an association with AD. The paper does not identify Serpina3n or establish that the gene is associated with AD risk. The increase in Abi3−/− mice is the citing authors’ own observation, not a finding attributed to this source. (LLM, conf=0.82)
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Research works printed but not linked: 1
- Shinohara Y, Yamamoto M, Ohsuga H, et al. Alpha 1 -anti-chymotrypsin and antitrypsin in CSF of patients with Alzheimer-type dementia, in: Alzheimer's Disease: Basic Mechanisms, Diagnosis and Therapeutic Strategies, Iqbal K, McLachlan DRC, Winblad B, Wisniewski M, Eds. John Wiley & Sons, Chichester, 1991, p541.
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Brosseron, F., Krauthausen, M., Kummer, M., & Heneka, M. T. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8657-1 · Cited by 447
Binding and uptake of Aβ1‐42 by primary human astrocytes in vitro
Nielsen, H. M., Veerhuis, R., Holmqvist, B., & Janciauskiene, S. (2009) · Glia · doi:10.1002/glia.20822 · Cited by 96
Karahan, H., Smith, D. C., Kim, B., Dabin, L. C., Al-Amin, M. M., Wijeratne, H. R. S., Pennington, T., Viana di Prisco, G., McCord, B., Lin, P. B.-C., et al. (2021) · Science Advances · doi:10.1126/sciadv.abe3954 · Cited by 53
Metadata
- Authors
- HARIGAYA, Y., SHOJI, M., NAKAMURA, T., MATSUBARA, E., HOSODA, K., & HIRAI, S.
- Affiliations
- Gunma University (JP)
- Teijin (Japan) (JP)
- Venue
- Internal Medicine
- Published
- 1995
- Volume
- 34
- Issue
- 6
- Pages
- 481-484
- ISSN
- 0918-2918 (ISSN-L)
- 1349-7235
- OpenAlex
- W1991950590
- Cited by
- 38
- References
- 0
- Citations by year
- 2021: 1 · 2020: 1 · 2014: 1 · 2013: 2 · 2012: 6
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Clinical Neurology › Cerebrospinal fluid and hydrocephalus
- Keywords
- alpha-1-antichymotrypsin, cerebrospinal fluid, Alzheimer's disease, late-onset Alzheimer's disease, early-onset Alzheimer's disease, plasma protein levels, biomarkers, normal aging
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Aging, alpha 1-Antichymotrypsin, Alzheimer Disease, Female, Humans, Male, Middle Aged, Radioimmunoassay, Age of Onset
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