Nanocarrier-based delivery approaches of mangiferin: an updated review on leveraging biopharmaceutical characteristics of the bioactive
Abstract
In recent years, bioactive constituents from plants have been investigated as an alternative to synthetic approaches of therapeutics. Mangiferin (MGF) is a xanthone glycoside extracted from Mangifera indica and has shown numerous medicinal properties, such as antimicrobial, anti-diarrhoeal, antiviral, anti-inflammatory, antihypertensive, anti-tumours, and anti-diabetic effects. However, there are numerous challenges to its effective therapeutic usage, including its low water solubility, limited absorption, and poor bioavailability. Nano formulation approaches in recent years exhibited potential for the delivery of phytoconstituents with key benefits of high entrapment, sustained release, enhanced solubility, stability, improved pharmacokinetics, and site-specific drug delivery. Numerous techniques have been employed for the fabrication of MGF-loaded Nano formulations, and each technique has its advantages and limitations. The nanocarriers that have been employed to fabricate MGF nanoformulations for various therapeutic purposes include; polymeric nanoparticles, nanostructure, lipid carriers, polymeric micelles, Nano emulsions, microemulsion & self-microemulsifying drug delivery system, solid lipid nanoparticles, gold nanoparticles, carbon nanotubes, transfersomes, nanoliposomes, ethosomes & transethosomes, and glycethosomes. Different biopharmaceutical characteristics (size, shape, entrapment efficiency, zeta potential, in vitro drug release, ex vivo drug permeation,, and in…
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Nanodelivery research consistently shows improvements in MGF solubility, uptake, and systemic exposure.
“This approach is justified by consistent improvements in solubility, uptake and systemic exposure demonstrated in nanodelivery research, as well as by early human PK findings that MGF monosodium salt substantially increases bioavailability compared with the parent compound (166,195).”
From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [195]
Early human PK findings show MGF monosodium salt substantially increases bioavailability compared with the parent compound.
“This approach is justified by consistent improvements in solubility, uptake and systemic exposure demonstrated in nanodelivery research, as well as by early human PK findings that MGF monosodium salt substantially increases bioavailability compared with the parent compound (166,195).”
From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [195]
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References 110 · Cited by 4
- Authors
- Vishwakarma, K. K., Hafeez, A., Usmani, S. A., Noor, L., & Khan, I. R.
- Affiliations
- Integral University (IN)
- Corresponding author
- Hafeez, Abdul
- Venue
- Current Pharmaceutical Biotechnology
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2025-10
- Volume
- 26
- Issue
- 14
- Pages
- 2270-2287
- ISSN
- 1389-2010 (ISSN-L)
- OpenAlex
- W4402815748
- Cited by
- 4
- References
- 110
- Citations by year
- 2026: 1 · 2025: 3
- FWCI
- 0.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Pharmaceutical Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Pharmacology and Nanomedicine Research
- Keywords
- mangiferin, nanocarriers, xanthone glycosides, mango, bioavailability enhancement, polymeric nanoparticles, polymeric micelles, solid lipid nanoparticles, nanoemulsions, self-microemulsifying drug delivery system, gold nanoparticles, carbon nanotubes, transfersomes, nanoliposomes, ethosomes, transethosomes, encapsulation efficiency, drug release, pharmacokinetics, patents
- MeSH terms
- Animals, Drug Carriers, Humans, Drug Delivery Systems, Xanthones, Nanoparticles
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