SGK-1 Signalling pathway is a key factor in cell survival in ischemic injury
Abstract
Serum and glucocorticoid-regulated kinases (SGK) are serine/threonine kinases that belong to AGC. The SGK-1, which responds to stress, controls a range of ion channels, cell growth, transcription factors, membrane transporters, cellular enzymes, cell survival, proliferation and death. Its expression is highly controlled by various factors such as hyperosmotic or isotonic oxidative stress, cell shrinkage, radiation, high blood sugar, neuronal injury, DNA damage, mechanical stress, thermal shock, excitement, dehydration and ischemia. The structural and functional deterioration that arises after a period of ischemia when blood flow is restored is referred to as ischemia/ reperfusion injury (I/R). The current review discusses the structure, expression, function and degradation of SGK-1 with special emphasis on the various ischemic injuries in different organs such as renal, myocardial, cerebral, intestinal and lungs. Furthermore, this review highlights the various therapeutic agents that activate the SGK-1 pathway and slow down the progression of I/R injuries.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
SGK1 plays a positive role in neuronal apoptosis during cerebral ischemia.
“Research indicates SGK1 plays a positive role in neuronal apoptosis during cerebral ischemia (Chaudhary et al., 2023; Zhang et al., 2014).”
From Serum/glucocorticoid regulated kinase 1 (SGK1) in neurological disorders: pain or gain (2024) · cites this paper as Chaudhary et al., 2023
No citation lists for this paper
No citation lists for this paper yet — checked again daily.
References 48 · Cited by 6
- Authors
- Chaudhary, M., Sharma, V., Bedi, O., Kaur, A., & Singh, T. G.
- Affiliations
- Chitkara University (IN)
- Corresponding author
- Singh, Thakur Gurjeet
- Venue
- Current Drug Targets
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2023-10
- Volume
- 24
- Issue
- 14
- Pages
- 1117-1126
- ISSN
- 1389-4501 (ISSN-L)
- OpenAlex
- W4388033719
- Cited by
- 6
- References
- 48
- Citations by year
- 2025: 4 · 2024: 2
- FWCI
- 0.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Drug Targets (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- SGK1, serum and glucocorticoid-regulated kinase, AGC kinases, ischemia-reperfusion injury, cell survival, oxidative stress, renal ischemia, myocardial ischemia, cerebral ischemia, intestinal ischemia, lung ischemia, therapeutic target
- MeSH terms
- Cell Survival, Humans, Ischemia, Signal Transduction, Reperfusion Injury, Protein Serine-Threonine Kinases, Immediate-Early Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
