Rapid Method for the Estimation of Octanol / Water Partition Coefficient (Log Poct) from Gradient RP-HPLC Retention and a Hydrogen Bond Acidity Term (Sigma alpha2H)

Cited by (155)

Items 101–155 of 155

  1. Design of a serotonin 4 receptor radiotracer with decreased lipophilicity for single photon emission computed tomography
    Nathalie Fresneau, Noé Dumas, Benjamin B. Tournier et al. · 2015 · European Journal of Medicinal Chemistry
  2. Chromatographic Approaches for Measuring Log P
    Sophie Martel, Davy Guillarme, Yveline Henchoz, Alexandra Galland, Jean‐Luc Veuthey, Serge L. Rudaz, Pierre‐Alain Carrupt · 2007 · Methods and principles in medicinal chemistry
  3. Modulating Cytotoxicity with Lego-like Chemistry: Upgrading Mitochondriotropic Antioxidants with Prototypical Cationic Carrier Bricks
    Sofia Benfeito, Carlos Fernandes, Daniel Chavarria et al. · 2023 · Journal of Medicinal Chemistry
  4. Investigation of Hydro-Lipophilic Properties of N-Alkoxyphenylhydroxynaphthalenecarboxamides †
    Iva Kapustíková, Andrzej Bąk, Tomáš Goněc, Jiří Kos, Violetta Kozik, Josef Jampílek · 2018 · Molecules
  5. Fundamental Methods in Drug Permeability, pKa, LogP and LogDx Determination
    Andrew Glory Mtewa, Kennedy J. Ngwira, Fanuel Lampiao · 2019 · Journal of Drug Research and Development
  6. Identification via a Parallel Hit Progression Strategy of Improved Small Molecule Inhibitors of the Malaria Purine Uptake Transporter that Inhibit Plasmodium falciparum Parasite Proliferation
    Yvett Sosa, Roman Deniskin, Ithiel James Frame et al. · 2019 · ACS Infectious Diseases
  7. Pharmacologic Activities¬ of 3’-Hydroxypterostilbene: Cytotoxic, Anti-Oxidant, Anti-Adipogenic, Anti-Inflammatory, Histone Deacetylase and Sirtuin 1 Inhibitory Activity
    Jody K. Takemoto, Connie M. Remsberg, Neal M. Davies · 2015 · Journal of Pharmacy & Pharmaceutical Sciences
  8. ESTIMATING THE LIPOPHILICITY OF NATURAL PRODUCTS USING A POLYMERIC REVERSED PHASE HPLC METHOD
    Bo Zheng, Lyndon M. West · 2009 · Journal of Liquid Chromatography & Related Technologies
  9. Molecular properties, including chameleonicity, as essential tools for designing the next generation of oral beyond rule of five drugs
    Giulia Caron, Diego García Jiménez, Maura Vallaro, Luigi Vitagliano, Lucia Lopez Lopez, Giulia Apprato, Giuseppe Ermondi · 2024 · ADMET & DMPK
  10. High-throughput logPo/w determination from UHPLC measurements: Revisiting the chromatographic hydrophobicity index
    Xavier Subirats, Martı́ Rosés, Elisabeth Bosch · 2015 · Journal of Pharmaceutical and Biomedical Analysis
  11. In vitro biomimetic HPLC and in vivo characterisation of GM6, an endogenous regulator peptide drug candidate for amyotrophic lateral sclerosis
    Klara Livia Valko, Mark S. Kindy, James G. Evans, Dorothy Ko · 2018 · ADMET & DMPK
  12. 17 LC/MS application in high-throughput adme screen
    Ron Kong · 2005 · Separation science and technology
  13. RP-HPLC analysis and in vitro identification of antimycobacterial activity of novel thiosemicarbazides and 1,2,4-triazole derivatives
    Jolanta Flieger, Małgorzata Tatarczak‐Michalewska, Monika Wujec · 2015 · Journal of Pharmaceutical and Biomedical Analysis
  14. Lipophilicity and antiproliferative activity profiling of 2-benzylidencycloalkanones
    Balázs Hallgas, Zsófia Dobos, Attila Agócs · 2007 · Journal of Chromatography B
  15. Lipophilicity Methods
    Edward H. Kerns, Li Di · 2008 · Elsevier eBooks
  16. Accurate automated logPo/w measurement by gradient-flow liquid–liquid partition chromatography
    Sandrine Demare, Bryan Slater, Gaëlle Lacombe · 2007 · Journal of Chromatography A
  17. Ion-pair reversed-phase chromatography analysis of oligonucleotides using ultra-short (20 x 2.1 mm) columns. Tutorial
    Szabolcs Fekete, Mateusz Imiołek, Matthew A. Lauber · 2024 · Journal of Chromatography Open
  18. RP-HPLC LIPOPHILICITY STUDIES FOR SOME (HETERO)ARYLAMIDES DERIVED FROM 2-AMINO 4,6-DIMETHYL PYRIDINE: INTRODUCTION OF AN HYDROGEN-BOND DESCRIPTOR
    Khalid Fikri, Jean Debord, Jean‐Claude Bollinger · 2011 · Journal of Liquid Chromatography & Related Technologies
  19. Chromatographic hydrophobicity index: pH profile for polyprotic compounds
    Elisabet Fuguet, Clara Ràfols, Elisabeth Bosch · 2009 · Journal of Chromatography A
  20. Chromatographic Hydrophobicity Index (CHI)
    Martı́ Rosés, Elisabeth Bosch, Clara Ràfols · 2012 · Advances in chromatography
  21. Styrylquinolines Derivatives: SAR Study and Synthetic Approaches
    Monika Saini, Rina Das, Dinesh Kumar Mehta · 2022 · Medicinal Chemistry
  22. Separation Techniques in Effect-Directed Analysis
    Werner Brack, Nadin Ulrich, Mahmoud Bataineh · 2011 · ˜The œhandbook of environmental chemistry
  23. Lipophilicity Methods
    Li Di, Edward H. Kerns · 2016 · Elsevier eBooks
  24. High-Throughput HPLC Method for the Measurement of Octanol–Water Partition Coefficients without an Organic Modifier
    Jonathan Rains, Elliot Steeples, Ben Robinson · 2025 · Analytical Chemistry
  25. Robustness of an Immobilized Artificial Membrane High-Performance Liquid Chromatography Method for the Determination of Lipophilicity
    Moira Ledbetter, Steve Gutsell, Geoff Hodges · 2012 · Journal of Chemical & Engineering Data
  26. Application of HPLC measurements for the determination of physicochemical and biomimetic properties to model in vivo drug distribution in support of early drug discovery
    Klara Livia Valko · 2020 · Handbook of analytical separations
  27. Solubility, Permeability, and Their Interplay
    Avital Beig, Milica Marković, Arik Dahan · 2018 · Methods and principles in medicinal chemistry
  28. Novel Cyclohexyl Amido Acid Antagonists of Lysophosphatidic Acid Type 1 Receptor for the Treatment of Pulmonary Fibrosis
    Marta Giuliani, Andrea Rizzi, Mafalda Pagano, Luca F. Raveglia, Francesca Saccani, Maria Rosaria Di Lascia, Margherita Interlandi, Tonia Simona Nardella, Gessica Marchini, Annalisa Murgo et al. · 2025 · ACS Medicinal Chemistry Letters
  29. Discovery of a Potent, Selective, and Blood-Brain Barrier Permeable Non-nitrocatechol Inhibitor of Catechol-O-methyltransferase
    Sofia Benfeito, Bárbara Albuquerque, Lisa Sequeira, Carla Lima, Daniel Chavarria, Paula Serrão, Fernando Cagide, Patrı́cio Soares-da-Silva, Fernanda Borges · 2024 · Journal of Medicinal Chemistry
  30. Biomimetic Chromatography: A Novel Approach for Measuring Phospholipid Membrane–Water and Protein–Water Partition Coefficients for Target and Suspect PFAS
    Derek J. Muensterman, Klara Livia Valko, Ruiwen Chen, Carla A. Ng, Boris Droz, Shubham Vyas, Mark J. Benotti, Jennifer A. Field · 2025 · Environmental Science & Technology
  31. Molecular modeling of wine polyphenols
    Vesna Rastija, Sonja Nikolić, Marica Medič-Šarić · 2009 · Journal of Mathematical Chemistry
  32. In VitroCharacterization of Small‐Molecule Kinase Inhibitors
    Doris Hafenbradl, Matthias Baumann, Lars Neumann · 2011 · Methods and principles in medicinal chemistry
  33. Effects of buffer salt types and non-counter ions of ion-pair reagents on the retention behavior of strongly ionized acid compounds in ion-pair reversed-phase liquid chromatography
    Xiaolan Liu, Wei Min Gao, Chao Liang · 2021 · Chinese Journal of Chromatography
  34. Chromatographic and computational studies of the physicochemical properties of cholinesterase inhibitors — alkyl- and arylcarbamate derivatives ofN-benzylpiperidine andN-benzylpiperazine
    Anna Więckowska, Marek Bajda, Krzysztof Więckowski · 2010 · Journal of Planar Chromatography – Modern TLC
  35. Acylglycinamides as inhibitors of glycine transporter type 1
    Richard J. Blunt, Roderick A. Porter, Amanda Johns et al. · 2011 · Bioorganic & Medicinal Chemistry Letters
  36. Application of High Performance Liquid Chromatography for the Measurements of Lipophilicity and Biomimetic Binding Properties in Drug Discovery
    Klara Livia Valko · 2012 · IAPC Publishing eBooks
  37. Isolation, Biochemical Identification and Antioxidant Activity of Locally Isolated Lactobacillus spp in Garmian Area
    Hana K. Maikhan, Saman M. Mohammad-Amin · 2017 · Eurasian Journal of Science and Engineering
  38. Retention-time prediction for polycyclic aromatic compounds in reversed-phase capillary electro-chromatography
    Peter Feenstra, Heidrun Gruber‐Wölfler, Michael Brunsteiner · 2015 · Journal of Molecular Modeling
  39. Fast-generic HPLC methods
    Ian Martin Mutton · 2020 · Handbook of analytical separations
  40. Automated Property Profiling for Cellular Drug Delivery
    Edward H. Kerns, Li Di · 2004 · Humana Press eBooks
  41. Simultaneous Analysis of Pesticide Multiresidues in Human Serum, Urine, Apiculture Samples, and Representative Crops Using Tandem Mass Spectrometry
    신용호 · 2018 · Seoul National University Open Repository (Seoul National University)
  42. Optimization Strategies Based on the Structure of the Analytes
    Christoph A. Fleckenstein · 2021
  43. Coarse-Grained Modeling of Drug Absorption into Plasticized PVC
    Meriem Sahnoune, Julien Devémy, Philip Chennell, Alain Dequidt, Valérie Sautou, Mehdi Sahihi, Patrice Malfreyt · 2026 · Journal of Chemical Theory and Computation
  44. (E)-2-benzylidenebenzocyclanones: Part X. Determination of logPof (E)-3-benzylidene-2,3-dihydro-1-benzopyran-4-ones by RP-TLC. Effect on logPof incorporation of oxygen atom into carbocyclic chalcone analogues
    Zsuzsanna Rozmer, Pál Perjési · 2013 · Journal of Planar Chromatography – Modern TLC
  45. Chapter 2 Solubility Determinations for Pharmaceutical API
    Kofi Asare‐Addo, Barbara R. Conway · 2017 · Pan Stanford Publishing eBooks
  46. Selected Chromatographic Methods for Determining the Biological Activity of Substances
    Elżbieta Grządka, Irena Malinowska · 2024 · Applied Sciences
  47. Correlation of solvent strength parameter with two molecular descriptors in reversed-phase liquid chromatography
    Toma Galaon, Edvin Caiali, Serban C. Moldoveanu · 2024 · Revue Roumaine de Chimie
  48. Development of experimental methods to determine high lipophilicity of new chemical compounds : applications to cyclosporin A and bioconcentration
    Guillot, Amandine · 2010 · Archive ouverte UNIGE (University of Geneva)
  49. Chemometric Characterization of Chromatographic Retention Parameters of Mesoionic 1,3,4‐Thiadiazolium‐3‐Aminides by Molecular Interaction Fields
    Maria Luiza C. Montanari, Anderson Coser Gaudio, Andrei Leitão, Tânia Mara Grigolli Almeida, Carlos Alberto Montanari · 2006 · Journal of Liquid Chromatography & Related Technologies
  50. Impact and Promise of SFC in the Pharmaceutical Industry
    Larry M. Miller, J. David Pinkston, Larry Thomas Taylor · 2019
  51. ADME Screening
    2012 · Methods and principles in medicinal chemistry
  52. Biomimetic Partitioning and Pharmacokinetic Insights into Phytocannabinoids
    Jared Kainalu Martin, Derek J. Muensterman, Boris Droz, Klara Livia Valko, Lisa Truong, Robyn L. Tanguay, Jennifer A. Field · 2026 · ACS Omega
  53. Property-enriched fragment descriptors for adaptive QSAR
    Fiorella Ruggiu · 2014 · theses.fr (ABES)
  54. Synthèse de nouveaux conjugués fluorocarbonés pour augmenter la stabilité métabolique de peptides thérapeutiques ciblant les récepteurs couplés aux protéines G : application aux peptides apeline et spexine, étude mécanistique et évaluation biologique.
    Sridévi M. Ramanoudjame · 2020 · theses.fr (ABES)
  55. Interactions entre médicaments injectables et polymères des dispositifs médicaux de perfusion : Expérience versus Simulation moléculaire
    Meriem Sahnoune Millot · 2024