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Betulinic Acid and Its Derivatives: A Review on their Biological Properties
Abstract
Betulinic acid is a naturally occurring pentacyclic triterpenoid and has been shown to exhibit a variety of biological activities including inhibition of human immunodeficiency virus (HIV), antibacterial, antimalarial, antiinflammatory, anthelmintic and antioxidant properties. This article reports a survey of the literature dealing with betulinic acid related biological properties that has appeared from the 1990s to the beginning of 2003. A broad range of medical and pharmaceutical disciplines are covered, including a brief introduction about discovery, phytochemical aspects, organic synthesis, anti-HIV and cytotoxic mechanisms of action. Various structural modifications carried out and their biological and pharmacokinetic profiles are also incorporated. Keywords: betulinic acid, anti-hiv derivatives, anti-hiv mechanism, anticancer derivatives, anticancer mechanism, antiinflammatory, antimalarial, biotransformation
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Cited by
Saponins: Properties, Applications and Processing
Güçlü-Üstündağ, Ö., & Mazza, G. (2007) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390600698197 · Cited by 1,043
Seca, A., & Pinto, D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19010263 · Cited by 686
Betulin and betulinic acid: triterpenoids derivatives with a powerful biological potential
Hordyjewska, A., Ostapiuk, A., Horecka, A., & Kurzepa, J. (2019) · Phytochemistry Reviews · doi:10.1007/s11101-019-09623-1 · Cited by 298
Pandey, D. K., & Kaur, P. (2018) · 3 Biotech · doi:10.1007/s13205-018-1174-6 · Cited by 27
Metadata
- Authors
- Yogeeswari, P., & Sriram, D.
- Venue
- Current Medicinal Chemistry
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2005-03-01
- Volume
- 12
- Issue
- 6
- Pages
- 657-666
- ISSN
- 0929-8673 (ISSN-L)
- OpenAlex
- W2077409457
- Cited by
- 553
- References
- 0
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- closed
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