Cited by 301Circadian rhythm and melatoninSleep and Work-Related Fatiguemelanin and skin pigmentation

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Clinical Uses of Melatonin: Evaluation of Human Trials

Sanchez-Barcelo, E.J., Mediavilla, M.D., Tan, D.X., Reiter, R.J.·2010·Current Medicinal Chemistry

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Abstract

During the last 20 years, numerous clinical trials have examined the therapeutic usefulness of melatonin in different fields of medicine. The objective of this article is to review, in depth, the science regarding clinical trials performed to date. The efficacy of melatonin has been assessed as a treatment of ocular diseases, blood diseases, gastrointestinal tract diseases, cardiovascular diseases, diabetes, rheumatoid arthritis, fibromyalgia, chronic fatigue syndrome, infectious diseases, neurological diseases, sleep disturbances, aging and depression. Melatonin has been also used as a complementary treatment in anaesthesia, hemodialysis, in vitro fertilization and neonatal care. The conclusion of the current review is that the use of melatonin as an adjuvant therapy seems to be well founded for macular degeneration, glaucoma, protection of the gastric mucosa, irritable bowel syndrome, arterial hypertension, diabetes, side effects of chemotherapy and radiation in cancer patients or hemodialysis in patients with renal insufficiency and, especially, for sleep disorders of circadian etiology (jet lag, delayed sleep phase syndrome, sleep deterioration associated with aging, etc.) as well as in those related with neurological degenerative diseases (Alzheimer, etc.,) or Smith-Magenis syndrome. The utility of melatonin in anesthetic procedures has been also confirmed. More clinical studies are required to clarify whether, as the preliminary data suggest, melatonin is useful for treatment of fibromyalgia, chronic fatigue syndrome, infectious diseases, neoplasias or neonatal care. Preliminary data regarding the utility of melatonin in the treatment of ulcerative colitis, Crohns disease, rheumatoid arthritis are either ambiguous or negative. Although in a few cases melatonin seems to aggravate some conditions, the vast majority of studies document the very low toxicity of melatonin over a wide range of doses. Keywords: Melatonin, macular degeneration, glaucoma, gastric mucosa, irritable bowel syndrome, ulcerative colitis, Crohn's disease, rheumatoid arthritis, arterial hypertension, diabetes, fibromyalgia, chronic fatigue syndrome, infectious diseases, neurological diseases, Smith-Magenis syndrome, sleep disturbances, jet lag, shift work, aging, depression, anesthesia, hemodialysis, in vitro fertilization, neonatal care, clinical trials

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Items 201–300 of 301

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“Melatonin is also used in adjuvant therapy for agerelated disorders including diabetes, neuro-degenerative diseases such as Alzheimer’s disease, glaucoma, macular degeneration, arterial hypertension, and insomnia associated with aging [514].”
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Antiplatelet Effect of Melatonin through Breastfeeding: A Pediatric Case Report
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“Several studies have shown that melatonin exhibits very low toxicity when administered at various doses [44].”
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Noncausal effects of genetic predicted depression and gastric cancer risk: A NHANES and Mendelian randomization studyPreprint
Liu, J., Chen, Y. H., & Zhang, P. Q. (2024) · Research Square · doi:10.21203/rs.3.rs-4194989/v1
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Moreira‐Almeida, A., Costa, M. D. A., & Coelho, H. S. (2024) · Springer eBooks · doi:10.1007/978-3-031-54545-0_5
The evaluation of the effect of biological control agents and melatonin against fusarium oxysporum infecting potatoes.
Mbatha, L. A. (2023) · doi:10.29086/10413/23084
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Hussain, K., Ara, T., & Mobasher, M. A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13814-0.00017-x
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Oyebanjo, O. T., Adetuyi, B. O., Olajide, P. A., Ambali, O. A., Oni, P. G., & Ogunlana, O. O. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13814-0.00009-0 · Cited by 1
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The role of melatonin in peripartum cardiomyopathy
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Additional file 1 of Melatonin induces the rejuvenation of long-term ex vivo expanded periodontal ligament stem cells by modulating the autophagic process
Tan, Y.-Z., Xu, X.-Y., Dai, J.-M., Yin, Y., He, X.-T., Zhang, Y.-L., Zhu, T.-X., An, Y., Tian, B., & Chen, F.-M. (2021) · Figshare · doi:10.6084/m9.figshare.14516624
Additional file 2 of Melatonin induces the rejuvenation of long-term ex vivo expanded periodontal ligament stem cells by modulating the autophagic process
Tan, Y.-Z., Xu, X.-Y., Dai, J.-M., Yin, Y., He, X.-T., Zhang, Y.-L., Zhu, T.-X., An, Y., Tian, B., & Chen, F.-M. (2021) · Figshare · doi:10.6084/m9.figshare.14516630
Additional file 3 of Melatonin induces the rejuvenation of long-term ex vivo expanded periodontal ligament stem cells by modulating the autophagic process
Tan, Y.-Z., Xu, X.-Y., Dai, J.-M., Yin, Y., He, X.-T., Zhang, Y.-L., Zhu, T.-X., An, Y., Tian, B., & Chen, F.-M. (2021) · Figshare · doi:10.6084/m9.figshare.14516633
Additional file 4 of Melatonin induces the rejuvenation of long-term ex vivo expanded periodontal ligament stem cells by modulating the autophagic process
Tan, Y.-Z., Xu, X.-Y., Dai, J.-M., Yin, Y., He, X.-T., Zhang, Y.-L., Zhu, T.-X., An, Y., Tian, B., & Chen, F.-M. (2021) · Figshare · doi:10.6084/m9.figshare.14516636
Intranasal Delivery of Natural Compounds: A Promising approach for Parkinson’s Disease therapy
Jadhav, P. D., Velhal, A. B., Redasani, V. K., & Rathod, S. T. (2026) · Asian Journal of Pharmaceutical Research · doi:10.52711/2231-5691.2026.00002
Melatonin hybrids as multifunctional therapeutic agents: A comprehensive review
Damirchi, E. K., Barani, A., Hamidi, S. M., & Ebrahimzadeh, M. A. (2026) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2026.119156

Authors: Sanchez-Barcelo, E. J., Mediavilla, M. D., Tan, D. X., & Reiter, R. J.
Affiliations: Universidad de Cantabria (ES)
ORCID: Reiter, R.J.
Venue: Current Medicinal Chemistry
Publisher: Bentham Science Publishers Ltd.
Published: 2010-07-01
Volume: 17
Issue: 19
Pages: 2070-2095
ISSN: 0929-8673 (ISSN-L)
DOI: 10.2174/092986710791233689
OpenAlex: W2121858140
Cited by: 301
References: 0
Citations by year: 2026: 3 · 2025: 5 · 2024: 12 · 2023: 12 · 2022: 16 · 2021: 21 · 2020: 24 · 2019: 20 · 2018: 16 · 2017: 27 · 2016: 17 · 2015: 14 · 2014: 23 · 2013: 33 · 2012: 28
FWCI: 13.15
Type: journal article
Language: en
Open access: closed
Locations: Current Medicinal Chemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
Keywords: melatonin, clinical efficacy, eye diseases, macular degeneration, glaucoma, gastrointestinal diseases, irritable bowel syndrome, ulcerative colitis, Crohn's disease, rheumatoid arthritis, cardiovascular disease, hypertension, diabetes mellitus, fibromyalgia, chronic fatigue syndrome, infectious diseases, neurological disorders, Alzheimer's disease, Smith-Magenis syndrome, sleep disorders, jet lag, shift work, aging, depression, anesthesia, hemodialysis, in vitro fertilization, neonatal care, adjuvant therapy
MeSH terms: Cardiovascular Diseases, Clinical Trials as Topic, Communicable Diseases, Endocrine System Diseases, Eye Diseases, Gastrointestinal Diseases, Hematologic Diseases, Humans, Melatonin, Muscular Diseases, Neoplasms, Nervous System Diseases, Fatigue Syndrome, Chronic

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