Cited by 230Computational Drug Discovery MethodsCholinesterase and Neurodegenerative DiseasesProtein Degradation and Inhibitors

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Polypharmacology in a Single Drug: Multitarget Drugs

L. Bolognesi, M.·2013·Current Medicinal Chemistry

DOI 10.2174/0929867311320130004

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Abstract

Polypharmacology offers a model for the way drug discovery must evolve to develop therapies most suited to treating currently incurable diseases. It is driven by a worldwide demand for safer, more effective, and affordable medicines against the most complex diseases, and by the failures of modern drug discovery to provide these. Polypharmacology can involve combinations and/or multitarget drugs (MTD). Although not mutually exclusive, my premise is that MTDs have inherent advantages over combinations. This review article focuses on MTDs from a medicinal chemistry perspective. I will explore their use in current clinical practice, their likely application in the future, and the challenges to be overcome to achieve this goal. Keywords: Multifactorial diseases, Combination therapy, multitarget drug discovery, network pharmacology, multitargetdirected ligands, designed multiple ligands

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Authors: L. Bolognesi, M.
Venue: Current Medicinal Chemistry
Publisher: Bentham Science Publishers Ltd.
Published: 2013-03-01
Volume: 20
Issue: 13
Pages: 1639-1645
ISSN: 0929-8673 (ISSN-L)
DOI: 10.2174/0929867311320130004
OpenAlex: W2329046360
Cited by: 230
References: 0
Citations by year: 2026: 15 · 2025: 7 · 2024: 23 · 2023: 11 · 2022: 27 · 2021: 23 · 2020: 35 · 2019: 19 · 2018: 12 · 2017: 16 · 2016: 13 · 2015: 13 · 2014: 9 · 2013: 7
FWCI: 16.79
Type: journal article
Language: en
Open access: closed
Locations: Current Medicinal Chemistry (publishedVersion)
PubMed (publishedVersion)
Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Computational Drug Discovery Methods
Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Degradation and Inhibitors
Keywords: polypharmacology, multi-target drugs, multi-target drug discovery, combination therapy, network pharmacology, multi-target-directed ligands, complex diseases
MeSH terms: Animals, Drug Combinations, Drug Resistance, Microbial, Pharmaceutical Preparations, Humans, Drug Discovery

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Polypharmacology in a Single Drug: Multitarget Drugs

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