The DOI matches its Crossref record.
Bioavailability of Quercetin: Problems and Promises
Abstract
Quercetin (QC) is a typical plant flavonoid, possesses diverse pharmacologic effects including antiinflammatory, antioxidant, anti-cancer, anti-anaphylaxis effects and against aging. However, the application of QC in pharmaceutical field is limited due to its poor solubility, low bioavailability, poor permeability and instability. To improve the bioavailability of QC, numerous approaches have been undertaken, involving the use of promising drug delivery systems such as inclusion complexes, liposomes, nanoparticles or micelles, which appear to provide higher solubility and bioavailability. Enhanced bioavailability of QC in the near future is likely to bring this product to the forefront of therapeutic agents for treatment of human disease.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“a clinical approach with the use of quercetin has been quite limited probably due to its poor permeability of the BBB, low bioavailability, and rapid metabolism (Cai et al., 2013)”
From Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes (2022) · cites this paper as Cai et al., 2013
Citations
Cited by
Sorted by citations
Wang, W., Sun, C., Mao, L., Ma, P., Liu, F., Yang, J., & Gao, Y. (2016) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2016.07.004 · Cited by 802
Oral bioavailability of curcumin: problems and advancements
Liu, W., Zhai, Y., Heng, X., Yuan, F., Chen, W., Sun, D., & Zhai, G. (2016) · Journal of drug targeting · doi:10.3109/1061186x.2016.1157883 · Cited by 567
“Reasons for poor bioavailability of any agent within the body are related to poor absorption, high rate of metabolism, and/or rapid elimination and clearance from the body [15].”
BackgroundSelf-citationNeuroprotective Effects of Quercetin in Alzheimer’s Disease
Khan, H. Z., Ullah, H., Aschner, M., Cheang, W. S., & Akkol, E. K. (2019) · Biomolecules · doi:10.3390/biom10010059 · Cited by 563
“Low solubility, poor absorption, and rapid metabolism are major aspects of the low bioavailability of quercetin [80].”
BackgroundPolyphenols and their benefits: A review
Rasouli, H., Farzaei, M. H., & Khodarahmi, R. (2017) · International Journal of Food Properties · doi:10.1080/10942912.2017.1354017 · Cited by 490
Improvement strategies for the oral bioavailability of poorly water-soluble flavonoids: An overview
Zhao, J., Yang, J. H., & Xie, Y. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118642 · Cited by 422
Metadata
- Authors
- Cai, X., Fang, Z., Dou, J., Yu, A., & Zhai, G.
- Affiliations
- Shandong University (CN)
- Corresponding author
- Fang, Z.
- Zhai, G.
- Venue
- Current Medicinal Chemistry
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2013-05-01
- Volume
- 20
- Issue
- 20
- Pages
- 2572-2582
- ISSN
- 0929-8673 (ISSN-L)
- OpenAlex
- W2133019478
- Cited by
- 423
- References
- 0
- Citations by year
- 2026: 39 · 2025: 39 · 2024: 42 · 2023: 53 · 2022: 46 · 2021: 42 · 2020: 42 · 2019: 29 · 2018: 22 · 2017: 15 · 2016: 22 · 2015: 17 · 2014: 11 · 2013: 4
- FWCI
- 10.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Health Sciences › Medicine › Pharmacology (medical) › Flavonoids in Medical Research
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Keywords
- quercetin, bioavailability, flavonoids, drug delivery systems, inclusion complexes, liposomes, nanoparticles, micelles, solubility enhancement, permeability, antioxidant activity, anti-inflammatory activity, anticancer activity
- MeSH terms
- Biocompatible Materials, Biological Availability, Drug Carriers, Half-Life, Humans, Liposomes, Micelles, Prodrugs, Quercetin, Solubility, Nanoparticles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
