Exosome-like Nanoparticles: A New Type of Nanocarrier
Open accessAbstract
Nanoparticles are one of the most commonly used systems for imaging or therapeutic drug delivery. Exosomes are nanovesicular carriers that transport cargo for intercellular communication. These nanovesicles are linked to the pathology of some major diseases, in some cases with a central role in their progression. The use of these carriers to transport therapeutic drugs is a recent and promising approach to treat diseases such as cancer and Alzheimer disease. The physiological production of these structures is limited impairing its collection and subsequent purification. These drawbacks inspired the search for mimetic alternatives. The collection of exosome-like nanoparticles from plants can be a good alternative, since they are easier to extract and do not have the drawbacks of those produced in animal cells. Both natural and synthetic exosome-like nanoparticles, produced from serial extrusion of cells or by bottom up synthesis, are currently some of the most promising, biocompatible, high efficiency systems for drug delivery.
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Exosomes have good biocompatibility as carriers, which can prolong the circulation half-time with therapeutic cargo.
“Therefore, exosomes have good biocompatibility as carriers, which can prolong the circulation half-time with therapeutic cargo [38].”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [38]
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References 159 · Cited by 51
- Authors
- Fernandes, M., Lopes, I., Teixeira, J., Botelho, C., & Gomes, A. C.
- Affiliations
- Centre of Biological Engineering (CEB), Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal
- University of Minho (PT)
- Corresponding author
- Gomes, Andreia C.
- Venue
- Current Medicinal Chemistry
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2020-07-01
- Volume
- 27
- Issue
- 23
- Pages
- 3888-3905
- ISSN
- 0929-8673 (ISSN-L)
- OpenAlex
- W2913577288
- Cited by
- 51
- References
- 159
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 10 · 2023: 3 · 2022: 12 · 2021: 10 · 2020: 2 · 2019: 4
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by-nc-sa
- Locations
- Current Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by-nc-sa)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by-nc-nd)
- Funders
- National funds through the Fundação para a Ciência e a Tecnologia (UID/BIA/04050/2019)
- Fundação para a Ciência e a Tecnologia (SFRH/BPD/ 111291/2015)
- Direcção Regional da Ciência e Tecnologia, Governo Regional dos Açores (M3.1.a/F/128/ 2015)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- exosome-like nanoparticles, nanocarriers, drug delivery, exosome mimetics, plant-derived nanoparticles, bottom-up synthesis, cancer therapy, Alzheimer's disease, intercellular communication, nanovesicles
- MeSH terms
- Animals, Cell Communication, Neoplasms, Biomimetics, Nanoparticles, Exosomes
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