Role and treatment of mitochondrial DNA-related mitochondrial dysfunction in sporadic neurodegenerative diseases
Open accessAbstract
Several sporadic neurodegenerative diseases display phenomena that directly or indirectly relate to mitochondrial function. Data suggesting altered mitochondrial function in these diseases could arise from mitochondrial DNA (mtDNA) are reviewed. Approaches for manipulating mitochondrial function and minimizing the downstream consequences of mitochondrial dysfunction are discussed. Keywords: Cybrids, endophenotype, mitochondria, mitochondrial DNA, mitochondrial medicine, neurodegenerative disease, mutations, platelet, vitamin E, autophagy
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Mitochondrial dysfunction initiates LOAD.
“Finally, as we believe mitochondrial dysfunction initiates LOAD, we would instead advocate developing mitochondrial or bioenergetic medicine approaches for the treatment of LOAD [263-266].”
From The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives (2014) · cites this paper as [265]
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References 318 · Cited by 35
Research works printed but not linked: 1
- [35]Parker WD Pascuzzi RM Sporadic neurologic disease and the electron transport chain: a hypothesis Proceedings of the 1989 Scientfic Meeting of the American Society for Neurological Investigation: New Developments in Neuromuscular Disease Bloomington 1990 Indiana Indiana University Printing Services
- Authors
- H. Swerdlow, R.
- Venue
- Current Pharmaceutical Design
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2011-10-01
- Volume
- 17
- Issue
- 31
- Pages
- 3356-3373
- ISSN
- 1381-6128 (ISSN-L)
- PMC
- PMC3351798
- OpenAlex
- W2005330884
- Cited by
- 35
- References
- 318
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 1 · 2014: 3 · 2013: 10 · 2012: 2
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Pharmaceutical Design (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (P30AG035982)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- mitochondrial dysfunction, mitochondrial DNA, cybrids, endophenotypes, mitochondrial medicine, mitochondrial mutations, platelets, vitamin E, autophagy
- MeSH terms
- DNA, Mitochondrial, Gene Expression Regulation, Humans, Mitochondria, Neurodegenerative Diseases, Genetic Predisposition to Disease
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