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Cited by 87Mast cells and histamineAsthma and respiratory diseasesFood Allergy and Anaphylaxis Research

The DOI matches its Crossref record; 349 of the 349 references it cites were found in a registry or an index.

Mast Cells in Allergic and Inflammatory Diseases

Sismanopoulos, Nikolaos, Delivanis, Danae-Anastasia, Alysandratos, Konstantinos-Dionysios, Angelidou, Asimenia, Therianou, Anastasia, Kalogeromitros, Dimitrios, C. Theoharides, Theoharis·2012·Current Pharmaceutical Design
DOI 10.2174/138161212800165997
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Abstract

Mast cells are important in the development of allergic and anaphylactic reactions, but also in acquired and innate immunity. There is also increasing evidence that mast cells participate in inflammatory diseases, where they can be activated by non-allergic triggers, such as neuropeptides and cytokines, often having synergistic effects as in the case of substance P (SP) and IL-33. Secretion of vasoactive mediators, cytokines and proteinases contribute to the development of coronary artery disease (CAD), as well as to diet-induced obesity and the metabolic syndrome. Mast cells may be able to orchestrate such different biological processes through their ability to release pro-inflammatory mediators selectively without the degranulation typical of allergic reactions. Recent evidence suggests that mitochondrial uncoupling protein 2 (UCP2) and mitochondrial translocation regulate mast cell degranulation, but not selective mediator release. Better understanding of these two processes and how mast cells exert both immunostimulatory and immunosuppressive actions could lead to the development of inhibitors of release of specific mediators with novel therapeutic applications.

Overview

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Crossref · 10.2174/138161212800165997

Cites

349 of 349 references verified0 citation errors · 0 not checkable

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Metadata

Authors
Sismanopoulos, N., Delivanis, D.-A., Alysandratos, K.-D., Angelidou, A., Therianou, A., Kalogeromitros, D., & C. Theoharides, T.
Affiliations
Tufts University (US)
ORCID
Venue
Current Pharmaceutical Design
Publisher
Bentham Science Publishers Ltd.
Published
2012-04-01
Volume
18
Issue
16
Pages
2261-2277
ISSN
1381-6128 (ISSN-L)
DOI
10.2174/138161212800165997
OpenAlex
W2151711434
Cited by
87
References
349
Citations by year
2026: 3 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 6 · 2020: 8 · 2019: 5 · 2018: 8 · 2017: 7 · 2016: 7 · 2015: 15 · 2014: 8 · 2013: 7
FWCI
4.18
Type
journal article
Language
en
Open access
closed
Locations
  • Current Pharmaceutical Design (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • State Scholarships Foundation
  • National Institutes of Health (5r01ns066205-05)
  • National Institute of Neurological Disorders and Stroke (NS55681, NS71361, R01NS071361, NS 66205)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR 47652, R01AR047652)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
  • Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
Keywords
mast cells, allergic reactions, anaphylaxis, inflammatory diseases, substance P, IL-33, neuropeptides, cytokines, coronary artery disease, diet-induced obesity, metabolic syndrome, mast cell degranulation, UCP2, mitochondrial uncoupling, immunosuppression
MeSH terms
Coronary Artery Disease, Diabetes Mellitus, Humans, Hypersensitivity, Inflammation, Mast Cells, Inflammation Mediators

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