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Prebiotic Chemistry: The Amino Acid and Peptide World
Abstract
In this review the idea of a “Peptide/Protein World” preceding the widely rooted idea of the “RNA world” is presented and elaborated. To support this idea, the formation of the building blocks of nucleic acids and peptides and their assembly to biopolymers in a primordial earth scenario is discussed. Furthermore, chemical stability problems of the building blocks and the assembled biomolecules are presented, and finally their ability to efficiently replicate and chemically evolve is argued. Taking into account various problems in all these areas for nucleic acids and nucleotides, the idea of the “Peptide/Protein World” is brought up, stating that peptides and proteins would have come first in chemical evolution with an “RNA world” appearing only later with the protective help of protein shells. Keywords: rna world, ultraviolet radiation, nucleobases, formaldehyde, hydrolyzation, salt-induced peptide formation (sipf), uv irradiation, replicators
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Amino acids can randomly polymerize to peptides under prebiotic, template-free conditions.
“Various studies have shown that amino acids can randomly polymerize to peptides (Plankensteiner et al., 2005), and nucleobases can form nucleic acid chains (Sutherland and Whitfield, 1997) under prebiotic, template-free conditions.”
From The Astrobiology Primer v2.0 (2016) · cites this paper as Plankensteiner et al., 2005
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The Origin of Life—Out of the Blue
Sutherland, J. D. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201506585 · Cited by 401
Prebiotic Peptides: Molecular Hubs in the Origin of Life
Frenkel-Pinter, M., Samanta, M., Ashkenasy, G., & Leman, L. J. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00664 · Cited by 354
Which Amino Acids Should Be Used in Prebiotic Chemistry Studies?
Zaia, D. A. M., Zaia, C. T. B. V., & De Santana, H. (2008) · Origins of Life and Evolution of Biospheres · doi:10.1007/s11084-008-9150-5 · Cited by 157
The Future of Origin of Life Research: Bridging Decades-Old Divisions
Preiner, M., Asche, S., Becker, S., Betts, H. C., Boniface, A., Camprubi, E., Chandru, K., Erastova, V., Garg, S. G., Khawaja, N., et al. (2020) · Life · doi:10.3390/life10030020 · Cited by 140
Domagal-Goldman, S. D., Wright, K. E., Domagal-Goldman, S. D., Wright, K. E., Adamala, K., Arina de la Rubia, L., Bond, J., Dartnell, L. R., Goldman, A. D., Lynch, K., et al. (2016) · Astrobiology · doi:10.1089/ast.2015.1460 · Cited by 136
“Various studies have shown that amino acids can randomly polymerize to peptides (Planken- steiner et al., 2005), and nucleobases can form nucleic acid chains (Sutherland and Whitfield, 1997) under prebiotic, template-free conditions.”
Wieczorek, R., Adamala, K., Gasperi, T., Polticelli, F., & Stano, P. (2017) · Life · doi:10.3390/life7020019 · Cited by 53
Prebiotic Reaction Networks in Water
Tran, Q. P., Adam, Z. R., & Fahrenbach, A. C. (2020) · Life · doi:10.3390/life10120352 · Cited by 32
Radicals in Prebiotic Chemistry
Lim, R. W. J., & Fahrenbach, A. C. (2020) · Pure and Applied Chemistry · doi:10.1515/pac-2020-0805 · Cited by 8
Metadata
- Authors
- Plankensteiner, K., Reiner, H., & Rode, B.
- Affiliations
- Universität Innsbruck (AT)
- Corresponding author
- Rode, Bernd
- Venue
- Current Organic Chemistry
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2005-08-01
- Volume
- 9
- Issue
- 12
- Pages
- 1107-1114
- ISSN
- 1385-2728 (ISSN-L)
- OpenAlex
- W1979016787
- Cited by
- 46
- References
- 0
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 1 · 2012: 5
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Organic Chemistry (publishedVersion)
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- prebiotic chemistry, RNA world, origin of life, chemical evolution, nucleotides, amino acids, peptide formation, nucleobases, formaldehyde, ultraviolet radiation, chemical stability, replicators, protein shell
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