The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Sports Medicine Applications of Platelet Rich Plasma
Abstract
Platelet rich plasma (PRP) is a powerful new biologic tool in sports medicine. PRP is a fraction of autologous whole blood containing and increased number of platelets and a wide variety of cytokines such as platelet derived growth factor (PDGF), vascular endothelial growth factor (VEGF) and transforming growth factor beta-1 (TGF-B1), fibroblast growth factor (FGF), Insulin-like growth factor-1 (IGF-1) among many others. Worldwide interest in this biologic technology has recently risen sharply. Basic science and preclinical data support the use of PRP for a variety of sports related injuries and disorders. The published, peer reviewed, human data on PRP is limited. Although the scientific evaluation of clinical efficacy is in the early stages, elite and recreational athletes already use PRP in the treatment of sports related injuries. Many questions remain to be answered regarding the use of PRP including optimal formulation, including of leukocytes, dosage and rehabilitation protocols. In this review, a classification for platelet rich plasma is proposed and the in-vitro, preclinical and human investigations of PRP applications in sports medicine will be reviewed as well as a discussion of rehabilitation after a PRP procedure. The regulation of PRP by the World Anti-Doping Agency will also be discussed. PRP is a promising technology in sports medicine; however, it will require more vigorous study in order to better understand how to apply it most effectively.
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Citations
Cites
Platelet concentrate injection improves Achilles tendon repair in rats
Aspenberg, P., & Virchenko, O. (2004) · Acta Orthopaedica Scandinavica · doi:10.1080/00016470410001708190 · Cited by 338
Murray, M. M., Spindler, K. P., Ballard, P., Welch, T. P., Zurakowski, D., & Nanney, L. B. (2007) · Journal of Orthopaedic Research · doi:10.1002/jor.20367 · Cited by 300
Bosch, G., René van Weeren, P., Barneveld, A., & van Schie, H. T. M. (2011) · The Veterinary Journal · doi:10.1016/j.tvjl.2009.10.014 · Cited by 60
Cited by
Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020
(2020) · doi:10.3390/ijms21207794 · Cited by 1,039
A Review of Platelet-Rich Plasma: History, Biology, Mechanism of Action, and Classification
Alves, R., & Grimalt, R. (2018) · Skin Appendage Disorders · doi:10.1159/000477353 · Cited by 732
Mishra, A. K., Skrepnik, N. V., Edwards, S. G., Jones, G. L., Sampson, S., Vermillion, D. A., Ramsey, M. L., Karli, D. C., & Rettig, A. C. (2014) · The American Journal of Sports Medicine · doi:10.1177/0363546513494359 · Cited by 396
Self-citationChen, X., Jones, I. A., Park, C., & Vangsness, C. T. (2018) · The American Journal of Sports Medicine · doi:10.1177/0363546517743746 · Cited by 294
Zhou, Y., Zhang, J., Wu, H., Hogan, M. V., & Wang, J. H.-C. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0172-4 · Cited by 187
Metadata
- Authors
- Mishra, A., Harmon, K., Woodall, J., & Vieira, A.
- Venue
- Current Pharmaceutical Biotechnology
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2012-05-01
- Volume
- 13
- Issue
- 7
- Pages
- 1185-1195
- ISSN
- 1389-2010 (ISSN-L)
- OpenAlex
- W2098153182
- Cited by
- 397
- References
- 3
- FWCI
- 23.46
- Type
- journal article
- Language
- en
- Open access
- closed
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