Cited by 268Proteins in Food SystemsSurfactants and Colloidal SystemsPickering emulsions and particle stabilization

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Engineering of Nanoemulsions for Drug Delivery

Sarker, Dipak·2005·Current Drug Delivery

DOI 10.2174/156720105774370267

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Abstract

Nanoemulsions, usually spherical, are a group of dispersed particles used for pharmaceutical and biomedical aids and vehicles that show great promise for the future of cosmetics, diagnostics, drug therapies and biotechnologies. They exist in a wide variety of forms that are dictated by the particle components. Nanoemulsions are generally considered to be in the size range of less than and around 100 nm in diameter. The particles can exist as water-in-oil and oil-in-water forms, where the core of the particle is either water or oil, respectively. More complex variations also exist but these are often larger. The longer-term properties of the particle are dependent on the composition of the adsorbed material lying at the dispersed droplet interface with the dispersion medium. This has an impact on the partitioning and extraction of droplet contents. Thermodynamically stable particles are characterized by having a very low surface tension and this produces a very large surface area. Nanoemulsions can also include small meta-stable very small-scale emulsions; here the surface properties and chemistry can strongly influence behaviour. Processing, storage and formulation composition can also have an impact on the longevity of a pharmaceutical preparation. Some revolutionary new nanoemulsion droplets based on fluorinated compounds are finding a number of widespread biomedical roles and applications. Developments in nanoemulsion technology are likely to lead to a much greater use of this medium in future pharmaceuticals.

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Background
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Background
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BackgroundInfluential
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Background
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“ir ture (7), health (8) and medicine (9).”
Background
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Method
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Background
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Influential
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Background
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Method
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Background
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Background
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Background
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BackgroundMethod
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Background
Evaluation of the in vitro release and permeation of Cordia verbenacea DC essential oil from topical dosage forms
da Silva, J. D., Gomes, M. V. D. S., Cabral, L. M., & de Sousa, V. P. (2019) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2019.101173 · Cited by 16
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Background
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Adamczak, M., Para, G., Simon, C., et al. (2013) · Journal of Microencapsulation · doi:10.3109/02652048.2012.752536 · Cited by 16
“Since nanoemulsions are optically transparent or translucent, generally it is easy to observe any symptoms of their destabilization (Sarker, 2005).”
Background
Using the pH sensitivity of switchable surfactants to understand the role of the alkyl tail conformation and hydrogen bonding at a molecular level in elucidating emulsion stability
Ambagaspitiya, T. D., Garza, D. J. C., Skelton, E., et al. (2024) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2024.08.156 · Cited by 15
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“We used a microfluidic technique to formulated this uniform, milky-white nanoemulsion (35).”
Method
The effect ofLavandula officinalisnanoemulsion on growth performance, body composition, haematology and immunity parameters ofOncorhynchus mykiss
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Nanobiotechnology in Drug Delivery
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“to increase the bioavailability of poorly soluble drugs 23–27 .”
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A microfluidic technique for generating monodisperse submicron-sized drops
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“The NEs are widely used colloidal dispersions in pharmaceutical applications as a biocompatible strategy to increase bioavailability of poorly soluble or lipophilic drugs (88, 115, 138, 147, 151).”
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Laser diffractometry of nanoparticles: frequent pitfalls & overlooked opportunities
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“Currently, nanoemulsions are produced by encapsulating hydrophobic essential oil in a hydrophilic-continuous phase (8, 9).”
Background
Conventional Nanosized Drug Delivery Systems for Cancer Applications
Vergallo, C., Hafeez, M. N., Iannotta, D., Santos, H. A., d’Avanzo, N., Dini, L., Cilurzo, F., Fresta, M., Marzio, L. D., & Christian, C. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-58174-9_1 · Cited by 12
Colloidal emulsions and particles as micronutrient and nutraceutical delivery systems
Velikov, K. P. (2012) · Elsevier eBooks · doi:10.1533/9780857095909.3.319 · Cited by 13
Use of herbal extract-based nanoemulsions for hair care application
Okole, B., Pillai, S. K., Ndzotoyi, P., et al. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822967-5.00007-2 · Cited by 11
Formulation and characterization of Cefuroxime Axetil nanoemulsion for improved bioavailability
Poddar, A., Patel, Y., & Sawant, K. K. (2012) · Journal of Pharmacy And Bioallied Sciences · doi:10.4103/0975-7406.94116 · Cited by 11
Novel emulsion-based delivery systems
Zhang, J. (2011) · University of Minnesota Digital Conservancy (University of Minnesota) · Cited by 11
Oxidation in Different Food Matrices
Chen, B., McClements, D. J., & Decker, E. A. (2013) · Elsevier eBooks · doi:10.1016/b978-0-9830791-6-3.50006-0 · Cited by 11
Nanoemulsions
Mostafa, D. M., El-Alim, S. H. A., & Kassem, A. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-811942-6.00006-6 · Cited by 10
Drug packaging and delivery using perfluorocarbon nanoparticles for targeted inhibition of vascular smooth muscle cells
Zhou, Z., Bai-gen, Z., Zhang, H., et al. (2009) · Acta Pharmacologica Sinica · doi:10.1038/aps.2009.146 · Cited by 10
Revolutionizing nanomedicine: Expanding horizons of nanoemulsions in drug delivery and beyond
Kumar, M., Chauhan, N., Kumar, D., Mahmood, S., Chopra, S., & Bhatia, A. (2024) · Journal of Dispersion Science and Technology · doi:10.1080/01932691.2024.2369835 · Cited by 9
Interfacial Effects and the Nano-Scale Disruption in Adsorbed-Layer of Acrylate Polymer-Tween 80 Fabricated Steroid-Bearing Emulsions: A Rheological Study of Supramolecular Materials
Adu-Gyamfi, N., & Sarker, D. K. (2021) · Nanomaterials · doi:10.3390/nano11061612 · Cited by 9
“The physical stability of an emulsion is determined by well-elucidated phenomena such as coalescence (droplet fusion), creaming (flotation of oil droplets to form a concentrated oil-rich supernatant layer), Oswald ripening and flocculation [4,5].”
BackgroundSelf-citation
Improving Drug Delivery on Candida Albicans Using Geraniol Nanoemulsion
Pontes, C. S., de Carvalho, G. G., Leite, A. R. P., Chorilli, M., & Spolidório, D. M. P. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15102475 · Cited by 10
“White or milky colors indicate larger particles [35,36]. of 19 White or milky colors indicate larger particles [35,36]. were not observed in organoleptic characteristics and signs of instability.”
Background
Nanoformulation and administration of PUFA-rich systems for applications in modern healthcare
Paul, D., Dey, T. K., & Dhar, P. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-46142-9.00007-4 · Cited by 10
The relevance of nanotechnology, hepato-protective agents in reducing the toxicity and augmenting the bioavailability of isotretinoin
Hosny, K. M., Alhakamy, N. A., & Nahyah, K. S. A. (2020) · Drug Delivery · doi:10.1080/10717544.2020.1862365 · Cited by 9
“SNEDDS are usually easily developed since they require no sophisticated procedures or high energy methods (Sarker, 2005; Hosny et al., 2020).”
Method
Characterisation and evaluation of self-microemulsifying drug delivery system of Brucea javanica oil
Wang, Y., Li, Y., Wu, J., & Shen, Q. (2012) · Micro & Nano Letters · doi:10.1049/mnl.2012.0091 · Cited by 9
Multiple linear regression applied to predicting droplet size of complex perfluorocarbon nanoemulsions for biomedical applications
Lambert, E., & Janjic, J. M. (2019) · Pharmaceutical Development and Technology · doi:10.1080/10837450.2019.1578372 · Cited by 8
“NEs are used widely to increase bioavailability of poorly soluble drugs (Sarker 2005; McClements and Rao 2011; Rajpoot et al. 2011; Kotta et al. 2012; Shakeel et al. 2012), can be further incorporated into other dosage forms, and can be produced at industrial scale (Sarker 2005; Mitri et al. 2012;…”
Development of Olanzapine Nano-Emulsion for Enhanced Brain Delivery
MadhusudanRao, Y., Shailaja, M., Ramakrishna, S., Ramesh, G., Reddy, K., & Diwan, P. (2012) · International Journal of Pharmaceutical Sciences and Nanotechnology · doi:10.37285/ijpsn.2012.5.1.9 · Cited by 9
“Nano-emulsions are the novel delivery systems find potential application in improving the solubility and bioavailability of poorly soluble drugs (Sarker, 2005; Shafiq et al., 2007).”
Background
Hydrodynamic collision and deformation of compound droplet pairs in confined shear flow
Mamun, S. M. A. A., & Farokhirad, S. (2024) · Physics of Fluids · doi:10.1063/5.0187395 · Cited by 7
Emulsifiers’ Composition Modulates Venous Irritation of the Nanoemulsions as a Lipophilic and Venous Irritant Drug Delivery System
Mao, C., Wan, J., Chen, H., et al. (2009) · AAPS PharmSciTech · doi:10.1208/s12249-009-9295-1 · Cited by 7
“(1) Control blank nanoemulsion (NE); (2) control diallyl trisulfide (DT) NE; (3) Poloxamer 188 (0.2%) DT NE; ( 4 ) Poloxamer 188 (0.4%) DT NE; (5) Poloxamer 188 (0.6%) DT NE; (6) Solutol HS15 (0.2%) DT NE; (7) Solutol HS15 (0.4%) DT NE; (8) Solutol HS15 (0.6%) DT NE. Each value represents the means of three measuremen…”
BackgroundMethodInfluential
Dimensional analysis of a novel low‐pressure device for the production of size‐tunable nanoemulsions
Souilem, I., Serra, C. A., Müller, R., et al. (2014) · AIChE Journal · doi:10.1002/aic.14690 · Cited by 7
Influence of Disperse Phase Transfer on Properties of Nanoemulsions Containing Oil Droplets with Different Compositions and Physical States
Gao, S., & McClements, D. J. (2019) · Food Biophysics · doi:10.1007/s11483-019-09585-z · Cited by 7
Encapsulation of Lethal, Functional, and Therapeutic Medicinal Nanoparticles and Quantum Dots for the Improved Diagnosis and Treatment of Infection
Dichello, G. A., & Sarker, D. K. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-46152-8.00027-5 · Cited by 7
Self-citation
Development of nanoparticulate formulation of coenzyme Q10 and comparison of plasma coenzyme Q10 response in a single supplementation with regular coenzyme Q10 using rats
Ok, H., Kim, S.-M., Park, J., Kim, K., Nam, H.-K., Kim, J. Y., & Kwon, O. (2012) · Journal of the Korean Society for Applied Biological Chemistry · doi:10.1007/s13765-012-2037-1 · Cited by 7
“A nano-emulsion should be stable in aqueous solution, because the rate of Brownian motion is much faster than the rate of creaming and sedimentation (Mosqueira et al., 2000; Sarker, 2005).”
Background
Architectures and Mechanical Properties of Drugs and Complexes of Surface-Active Compounds at Air-Water and Oil-Water Interfaces
Sarker, D. K. (2017) · Current Drug Discovery Technologies · doi:10.2174/1570163814666171117132202 · Cited by 6
Self-citation
Synthesis, Characterization and Cytoxicity Evaluation of Syzygium Aromaticum L. Bud (Clove) Essential Oil NanoemulsionPreprint
Abadi, A. V. M., Karimi, E., Oskoueian, E., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-952488/v1 · Cited by 6
Emulsions, Microemulsions, and Lipid-Based Drug Delivery Systems for Drug Solubilization and Delivery—Part I
Cannon, J., Shi, Y., & Gupta, P. (2008) · CRC Press eBooks · doi:10.1201/9781420009552.ch10 · Cited by 5

Authors: Sarker, D.
Affiliations: University of Brighton (GB)
Corresponding author: Sarker, Dipak
ORCID: Sarker, Dipak
Venue: Current Drug Delivery
Publisher: Bentham Science Publishers Ltd.
Published: 2005-10-01
Volume: 2
Issue: 4
Pages: 297-310
ISSN: 1567-2018 (ISSN-L)
DOI: 10.2174/156720105774370267
OpenAlex: W2076616392
Cited by: 268
References: 0
Citations by year: 2026: 5 · 2025: 8 · 2024: 11 · 2023: 8 · 2022: 16 · 2021: 14 · 2020: 19 · 2019: 18 · 2018: 10 · 2017: 20 · 2016: 19 · 2015: 10 · 2014: 13 · 2013: 18 · 2012: 17
FWCI: 12.84
Type: journal article
Language: en
Open access: closed
Locations: Current Drug Delivery (publishedVersion)
PubMed (publishedVersion)
University of Brighton Repository (University of Brighton) (submittedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Proteins in Food Systems
Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Surfactants and Colloidal Systems
Physical Sciences › Materials Science › Materials Chemistry › Pickering emulsions and particle stabilization
Keywords: nanoemulsions, drug delivery, water-in-oil emulsions, oil-in-water emulsions, droplet interface, surface tension, surface area, fluorinated compounds, emulsion stability, drug formulation, cosmetics, diagnostics
MeSH terms: Animals, Colloids, Drug Compounding, Emulsions, Humans, Technology, Pharmaceutical, Drug Delivery Systems, Nanotechnology, Nanotubes

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Engineering of Nanoemulsions for Drug Delivery

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