An Overview of Chitosan Nanofibers and their Applications in the Drug Delivery Process
Abstract
Chitosan is a polycationic natural polymer which is abundant in nature. Chitosan has gained much attention as natural polymer in the biomedical field. The up to date drug delivery as well as the nanotechnology in controlled release of drugs from chitosan nanofibers are focused in this review. Electrospinning is one of the most established and widely used techniques for preparing nanofibers. This method is versatile and efficient for the production of continuous nanofibers. The chitosan-based nanofibers are emerging materials in the arena of biomaterials. Recent studies revealed that various drugs such as antibiotics, chemotherapeutic agents, proteins and anti-inflammatory analgesic drugs were successfully loaded onto electrospun nanofibers. Chitosan nanofibers have several outstanding properties for different significant pharmaceutical applications such as wound dressing, tissue engineering, enzyme immobilization, and drug delivery systems. This review highlights different issues of chitosan nanofibers in drug delivery applications, starting from the preparation of chitosan nanofibers, followed by giving an idea about the biocompatibility and degradation of chitosan nanofibers, then describing how to load the drug into the nanofibers. Finally, the major applications of chitosan nanofibers in drug delivery systems.
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Aware of these issues, the cosmetics industry has been encouraging sustainable procedures in an effort to mitigate the environmental effects of employing nanomaterials.
“Aware of these issues, the cosmetics industry has been encouraging sustainable procedures in an effort to mitigate the environmental effects of employing nanomaterials.”
From AN OVERVIEW OF NEW TRENDS IN THE COSMETICS INDUSTRY (2025) · cites this paper as [90]
Researchers and regulatory agencies are still looking for strategies to control these dangers, such as creating more precise rules for the appropriate application of nanotechnology in cosmetics.
“But, because of the intricacy of nanoparticle behavior in the environment, researchers and regulatory agencies are still looking for strategies to control these dangers, such as creating more precise rules for the appropriate application of nanotechnology in cosmetics.”
From AN OVERVIEW OF NEW TRENDS IN THE COSMETICS INDUSTRY (2025) · cites this paper as [90]
Some businesses are using biodegradable nanoparticles and carrying out more thorough environmental effect analyses.
“Some businesses, for example, are using biodegradable nanoparticles and carrying out more thorough environmental effect analyses.”
From AN OVERVIEW OF NEW TRENDS IN THE COSMETICS INDUSTRY (2025) · cites this paper as [90]
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References 175 · Cited by 92
- Authors
- AL-Jbour, N. D., Beg, M. D., Gimbun, J., & Alam, A. K. M. M.
- Affiliations
- Universiti Malaysia Pahang Al-Sultan Abdullah (MY)
- Corresponding author
- Beg, Mohammad D.
- Venue
- Current Drug Delivery
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2019-04-10
- Volume
- 16
- Issue
- 4
- Pages
- 272-294
- ISSN
- 1567-2018 (ISSN-L)
- OpenAlex
- W2911238040
- Cited by
- 92
- References
- 175
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 9 · 2023: 15 · 2022: 12 · 2021: 29 · 2020: 4 · 2019: 2
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Drug Delivery (publishedVersion)
- PubMed (publishedVersion)
- UMP Institutional Repository (Universiti Malaysia Pahang) (acceptedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
- Keywords
- chitosan nanofibers, drug delivery, electrospinning, controlled drug release, natural polymers, wound dressings, tissue engineering, enzyme immobilization, biocompatibility, biodegradation, drug loading, antibiotics, anticancer agents
- MeSH terms
- Analgesics, Animals, Anti-Bacterial Agents, Antineoplastic Agents, Humans, Drug Delivery Systems, Chitosan, Nanomedicine, Nanofibers
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