Cited by 92Electrospun Nanofibers in Biomedical ApplicationsAdvanced Drug Delivery SystemsSilk-based biomaterials and applications

An Overview of Chitosan Nanofibers and their Applications in the Drug Delivery Process

AL-Jbour, Nawzat D., Beg, Mohammad D., Gimbun, Jolius, Alam, A.K.M. Moshiul·2019·Current Drug Delivery

Abstract

Chitosan is a polycationic natural polymer which is abundant in nature. Chitosan has gained much attention as natural polymer in the biomedical field. The up to date drug delivery as well as the nanotechnology in controlled release of drugs from chitosan nanofibers are focused in this review. Electrospinning is one of the most established and widely used techniques for preparing nanofibers. This method is versatile and efficient for the production of continuous nanofibers. The chitosan-based nanofibers are emerging materials in the arena of biomaterials. Recent studies revealed that various drugs such as antibiotics, chemotherapeutic agents, proteins and anti-inflammatory analgesic drugs were successfully loaded onto electrospun nanofibers. Chitosan nanofibers have several outstanding properties for different significant pharmaceutical applications such as wound dressing, tissue engineering, enzyme immobilization, and drug delivery systems. This review highlights different issues of chitosan nanofibers in drug delivery applications, starting from the preparation of chitosan nanofibers, followed by giving an idea about the biocompatibility and degradation of chitosan nanofibers, then describing how to load the drug into the nanofibers. Finally, the major applications of chitosan nanofibers in drug delivery systems.

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Crossref · 10.2174/1567201816666190123121425

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    “Some businesses, for example, are using biodegradable nanoparticles and carrying out more thorough environmental effect analyses.”

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References 175 · Cited by 92

Authors
AL-Jbour, N. D., Beg, M. D., Gimbun, J., & Alam, A. K. M. M.
Affiliations
Universiti Malaysia Pahang Al-Sultan Abdullah (MY)
Corresponding author
Beg, Mohammad D.
Venue
Current Drug Delivery
Published
2019-04-10
Volume
16
Issue
4
Pages
272-294
ISSN
1567-2018 (ISSN-L)
OpenAlex
W2911238040
Cited by
92
References
175
Citations by year
2026: 7 · 2025: 14 · 2024: 9 · 2023: 15 · 2022: 12 · 2021: 29 · 2020: 4 · 2019: 2
FWCI
0.75
Type
journal article
Language
en
Open access
closed
Locations
  • Current Drug Delivery (publishedVersion)
  • PubMed (publishedVersion)
  • UMP Institutional Repository (Universiti Malaysia Pahang) (acceptedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
Keywords
chitosan nanofibers, drug delivery, electrospinning, controlled drug release, natural polymers, wound dressings, tissue engineering, enzyme immobilization, biocompatibility, biodegradation, drug loading, antibiotics, anticancer agents
MeSH terms
Analgesics, Animals, Anti-Bacterial Agents, Antineoplastic Agents, Humans, Drug Delivery Systems, Chitosan, Nanomedicine, Nanofibers

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