The DOI matches its Crossref record; 135 of the 138 references it cites were found in a registry or an index.
Garlic [Allium sativum]: A Review of its Potential Use as an Anti-Cancer Agent
Abstract
Garlic [Allium sativum] is among the oldest of all cultivated plants. It has been used as a medicinal agent for thousands of years. It is a remarkable plant, which has multiple beneficial effects such as antimicrobial, antithrombotic, hypolipidemic, antiarthritic, hypoglycemic and antitumor activity. In this review, we will discuss particularly the largely preclinical use of this agent in the treatment and prevention of cancer. A number of studies have demonstrated the chemopreventive activity of garlic by using different garlic preparations including fresh garlic extract, aged garlic, garlic oil and a number of organosulfur compounds derived from garlic. The chemopreventive activity has been attributed to the presence of organosulfur compounds in garlic. How this is achieved is not fully understood, but several modes of action have been proposed. These include its effect on drug metabolizing enzymes, antioxidant properties and tumor growth inhibition. Most of these studies were carried out in the animal models. Also, recent research has focused on the antimutagenic activity of garlic. Recently, it has been observed that aged garlic extract, but not the fresh garlic extract, exhibited radical scavenging activity. The two major compounds in aged garlic, S-allylcysteine and S-allylmercapto-L-cysteine, had the highest radical scavenging activity. In addition, some organosulfur compounds derived from garlic, including S-allylcysteine, have been found to retard the growth of chemically induced and transplantable tumors in several animal models. Therefore, the consumption of garlic may provide some kind of protection from cancer development.
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“Previous studies reported that allicin can easily degrade under the influence of temperature to form ajoenes ((E)- and (Z)-4, 5, 9-trithiadodeca-1, 6, 11-triene-9-oxides) and vinyldithiins which are more stable than allicin [43].”
From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [43]
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Edris, A. E. (2007) · Phytotherapy Research · doi:10.1002/ptr.2072 · Cited by 1,264
Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review
El-Saber Batiha, G., Magdy Beshbishy, A., G. Wasef, L., Elewa, Y. H. A., A. Al-Sagan, A., Abd El-Hack, M. E., Taha, A. E., M. Abd-Elhakim, Y., & Prasad Devkota, H. (2020) · Nutrients · doi:10.3390/nu12030872 · Cited by 931
Biological properties of garlic and garlic‐derived organosulfur compounds
Iciek, M., Kwiecień, I., & Włodek, L. B. (2009) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20474 · Cited by 478
Phenolics as antioxidants in garlic (Allium sativum L., Alliaceae)
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Black garlic: A critical review of its production, bioactivity, and application
Kimura, S., Tung, Y., Pan, M., Su, N., Lai, Y., & Cheng, K. (2016) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2016.11.003 · Cited by 311
Metadata
- Authors
- Thomson, M., & Ali, M.
- Affiliations
- Kuwait University (KW)
- ORCID
- Thomson, Martha
- Venue
- Current Cancer Drug Targets
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2003-02-01
- Volume
- 3
- Issue
- 1
- Pages
- 67-81
- ISSN
- 1568-0096 (ISSN-L)
- OpenAlex
- W2139539409
- Cited by
- 399
- References
- 138
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 19 · 2023: 25 · 2022: 30 · 2021: 31 · 2020: 25 · 2019: 25 · 2018: 15 · 2017: 13 · 2016: 20 · 2015: 27 · 2014: 23 · 2013: 18 · 2012: 13
- FWCI
- 19.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Cancer Drug Targets (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Physical Sciences › Chemistry › Organic Chemistry › Chemical synthesis and alkaloids
- Keywords
- garlic, anticancer activity, chemoprevention, organosulfur compounds, aged garlic extract, garlic oil, S-allylcysteine, free radical scavenging, antioxidant activity, antimutagenic activity, drug-metabolizing enzymes, tumor growth inhibition, medicinal plants
- MeSH terms
- Antineoplastic Agents, Phytogenic, Antioxidants, Cell Cycle, Garlic, Humans, Phytotherapy, Neoplasms, Plant Extracts, Plants, Medicinal, Apoptosis
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