Antihyperglycemic and antidyslipidemic activities of the aqueous Salvia hispanica extract in diabetic rat
Abstract
AIMS: The study targeted to evaluate the antihyperglycemic activity of Salvia hispanica. BACKGROUND: Salvia hispanica L. (Lamiaceae) is a medicinal plant with many beneficial properties on human health. OBJECTIVE: This objective of the study was to investigate the antihyperglycemic effect of the aqueous extract of Salvia hispanica (S. hispanica) seeds and its capacity to improve lipid profile in normal and STZ-induced diabetic rats. MATERIAL AND METHODS: The seed aqueous extract of S. hispanica (SHSAE) at a dose of 100 mg/kg was administered orally in normal and diabetic rats. The effect of oral SHSAE treatment on blood glucose and lipid levels during 15 days was assessed in normal and streptozotocin-induced diabetic rats. The oral glucose tolerance test (OGTT) was carried out. The antioxidant activity of SHSAE was also examined. RESULTS: The decrease of glycemia in rats following the administration of the plant extract suggested that the studied extract possesses antidiabetic effect. The extract of S. hispanica produced hypolipidemic effect with a significant lowering effect on plasma total cholesterol levels and increased on HDL-cholesterol levels. SHSAE was also able to enhance glucose tolerance using OGTT. Moreover, SHSAE possesses a potential antioxidant effect in vitro. CONCLUSION: In conclusion, this study demonstrates the antihyperglycemic and antilipidemic effects of SHSAE in rats.
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Quinoa possesses health benefits such as anti-obesity, hypocholesterolemic effect, antioxidant properties, and cardiovascular disease benefits.
“Quinoa is well known for its nutritional properties, due to which it possesses various health benefits such as anti-obesity, hypocholesterolemic effect, antioxidant properties, and cardiovascular diseases [115].”
From Nutritional and Functional New Perspectives and Potential Health Benefits of Quinoa and Chia Seeds (2023) · cites this paper as [115]
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References 37 · Cited by 9
- Authors
- Fadwa, E.-O., Amssayef, A., & Eddouks, M.
- Affiliations
- Team of Ethnopharmacology and Pharmacognosy, Department of Biology, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, BP 509, Boutalamine, 52000, Errachidia, Morocco
- Université Moulay Ismail de Meknes (MA)
- Corresponding author
- Eddouks, Mohamed
- Venue
- Cardiovascular & Hematological Agents in Medicinal Chemistry
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2022-03
- Volume
- 20
- Issue
- 1
- Pages
- 60-66
- ISSN
- 1871-5257 (ISSN-L)
- OpenAlex
- W3119200743
- Cited by
- 9
- References
- 37
- Citations by year
- 2025: 1 · 2023: 5 · 2022: 2 · 2021: 1
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cardiovascular & Hematological Agents in Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Centre National pour la Recherche Scientifique et Technique, CNRST (PPR/2015/35)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Health Sciences › Medicine › Complementary and alternative medicine › Nigella sativa pharmacological applications
- Keywords
- Salvia hispanica, antidiabetic activity, hypolipidemic effect, streptozotocin-induced diabetes, glucose tolerance, lipid profile, total cholesterol, HDL cholesterol, antioxidant activity, aqueous plant extract, medicinal plants
- MeSH terms
- Salvia hispanica, Animals, Diabetes Mellitus, Experimental, Hypoglycemic Agents, Plant Extracts, Streptozocin, Rats, Wistar, Rats
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