Recent advances in the oral delivery of insulin
Abstract
Insulin was discovered over 90 years ago. However oral insulin still remains a challenging and elusive goal. Extensive efforts are being made worldwide for developing noninvasive drug delivery systems, mainly via oral route as it is the most widely accepted means of administration. The main barriers faced in oral protein delivery are the enzymatic degradation and poor permeability across the intestinal wall. The approaches for developing an oral insulin delivery system mainly focus on overcoming these barriers. To overcome the gastro-intestinal barriers various types of formulations such as insulin conjugates, permeation enhancers, micro/nanoparticles, liposomes etc. are investigated. In the recent years a number of advances have taken place in understanding the needs and workable mechanisms of improved oral peptide delivery systems. In this review the recent patents on oral insulin is focused. Emphasis is on the technologies based on permeation enhancers and nanoparticle based carrier systems.
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Various drug delivery techniques, such as pH-responsive hydrogels, microparticles, nanoparticles, permeation enhancers, and insulin conjugates, have been developed to address oral insulin delivery issues.
“Various drug delivery techniques, such as pH-responsive hydrogels, microparticles, nanoparticles, permeation enhancers, and insulin conjugates, have been developed to address these issues (Ramesan and Sharma, 2014).”
From pH stimuli-responsive hydrogels from non-cellulosic biopolymers for drug delivery. (2023) · cites this paper as Ramesan and Sharma, 2014
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Rizwan, M., Yahya, R., Hassan, A., Yar, M., Azzahari, A., Selvanathan, V., Sonsudin, F., & Abouloula, C. (2017) · Polymers · doi:10.3390/polym9040137 · Cited by 844 · see citing works
pH stimuli-responsive hydrogels from non-cellulosic biopolymers for drug delivery.
Vegad, U., Patel, M., Khunt, D., Zupančič, O., Chauhan, S., & Paudel, A. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1270364 · Cited by 85 · see citing works
“Various drug delivery techniques, such as pH-responsive hydrogels, microparticles, nanoparticles, permeation enhancers, and insulin conjugates, have been developed to address these issues (Ramesan and Sharma, 2014).”
Background
- Authors
- Ramesan, R., & Sharma, C.
- Affiliations
- Sree Chitra Thirunal Institute for Medical Sciences and Technology (IN)
- ORCID
- Sharma, Chandra
- Venue
- Recent Patents on Drug Delivery & Formulation
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2014-07-07
- Volume
- 8
- Issue
- 2
- Pages
- 155-159
- ISSN
- 1872-2113 (ISSN-L)
- OpenAlex
- W2084773630
- Cited by
- 12
- References
- 0
- Citations by year
- 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 2
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Recent Patents on Drug Delivery & Formulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
- Keywords
- oral insulin delivery, oral protein delivery, enzymatic degradation, intestinal permeability, penetration enhancers, nanocarriers, liposomes, micro- and nanoparticles, oral peptide delivery, patents
- MeSH terms
- Administration, Oral, Humans, Hypoglycemic Agents, Insulin, Patents as Topic, Drug Delivery Systems
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