Effects of maternal obesity and gestational diabetes mellitus on the placenta: current knowledge and targets for therapeutic interventions
Abstract
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Gestational diabetes is associated with high aerobic fetal metabolism and hypoxia, stimulating the placenta to increase angiogenesis, resulting in increased number of capillaries; placentas also show abnormal endocrine function, increased inflammation, and changes in placental transporters.
“Gestational diabetes is associated with high aerobic fetal metabolism and hypoxia, stimulating the placenta to in crease angiogenesis, resulting in increased number of capillaries. The placentas also show abnormal endocrine function, increased inflam mation, and changes in placental transporters (Bedell et al., 2021; Denison et al., 2010; Gaither et al., 1999; Segura et al., 2017”
From Pregnancy-related maternal physiological adaptations and fetal chemical exposure (2023) · cites this paper as Bedell et al., 2021
Hyperglycemia has been shown to decrease cytotrophoblast invasive ability, which is essential for the transformation of the spiral arteries and inadequate in placental dysfunction.
“However, hyperglycemia has also been shown to decrease the cyto trophoblasts invasive ability which is, as previously mentioned, essential for the transformation of the spiral arteries, and inadequate in placental dysfunction (Bedell et al., 2021).”
From Pregnancy-related maternal physiological adaptations and fetal chemical exposure (2023) · cites this paper as Bedell et al., 2021
Cited by
Sorted by citations
Pregnancy-related maternal physiological adaptations and fetal chemical exposure
Vinnars, M.-T., Bixo, M., & Damdimopoulou, P. (2023) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2023.112064 · Cited by 32 · see citing works
- Authors
- Bedell, S.
- Corresponding author
- Bedell, Samantha
- ORCID
- Bedell, Samantha
- Venue
- Current Vascular Pharmacology
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2021
- Volume
- 19
- Issue
- 2
- Pages
- 176-192
- ISSN
- 1570-1611 (ISSN-L)
- 1875-6212
- OpenAlex
- W4312685764
- Cited by
- 57
- References
- 0
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 15 · 2023: 20 · 2022: 5 · 2021: 1
- FWCI
- 9.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Vascular Pharmacology (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- maternal obesity, gestational diabetes mellitus, placenta, placental insufficiency, therapeutic interventions, pregnancy complications
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