Mitochondrial Targeted Antioxidant in Cerebral Ischemia
Open accessAbstract
There has been much evidence suggesting that reactive oxygen species (ROS) generated in mitochondria during cerebral ischemia play a major role in programming the senescence of organism. Antioxidants dealing with mitochondria slow down the appearance and progression of symptoms in cerebral ischemia and increase the life span of organisms. The mechanisms of mitochondrial targeted antioxidants, such as SKQ1, Coenzyme Q10, MitoQ, and Methylene blue, include increasing adenosine triphosphate (ATP) production, decreasing production of ROS and increasing antioxidant defenses, providing benefits in neuroprotection following cerebral ischemia. A number of studies have shown the neuroprotective role of these mitochondrial targeted antioxidants in cerebral ischemia. Here in this short review we have compiled the literature supporting consequences of mitochondrial dysfunction, and the protective role of mitochondrial targeted antioxidants.
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Coenzyme Q10, SkQ1, mitoquinone and methylene blue are among mitochondria targeted antioxidants exerting a role in counteracting OS-induced senescence, with CoQ10 being the most studied.
“Coenzyme Q10 (CoQ10), SkQ1 (a.k.a. visomitin), mitoquinone (MitoQ) and methylene blue are among the mitochondria targeted antioxidants exerting a role in counteracting OS-induced senescence, with CoQ10 being the most studied (Table 1 and Table 2) [57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [57]
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References 72 · Cited by 38
Research works printed but not linked: 1
- [47]Lemke M Frei B Ames BN Faden AI Decreases in tissue levels of ubiquinol 9 and 10, ascorbate and alpha-tocopherol following spinal cord impact trauma in rats. Neurosci Lett 1990 108 201 206 2304630
- Authors
- Ahmed, E., Donovan, T., Yujiao, L., & Zhang, Q.
- Affiliations
- Augusta University (US)
- Corresponding author
- Zhang, Quanguang
- ORCID
- Zhang, Quanguang
- Venue
- Journal of Neurology and Neuroscience
- Publisher
- Scitechnol Biosoft Pvt. Ltd.
- Published
- 2015
- Volume
- 06
- Issue
- 02
- ISSN
- 2171-6625 (ISSN-L)
- PMC
- PMC4771373
- OpenAlex
- W2339153852
- Cited by
- 38
- References
- 72
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 7 · 2020: 6 · 2019: 6 · 2018: 3 · 2017: 4 · 2016: 1
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neurology and Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS086929)
- Topics
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Keywords
- mitochondria-targeted antioxidants, cerebral ischemia, reactive oxygen species, mitochondrial dysfunction, neuroprotection, SkQ1, coenzyme Q10, MitoQ, methylene blue, ATP production, aging, antioxidant defense
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