Epigenomics: Genome-Wide Study of Methylation Phenomena
Open accessAbstract
Epigenetics is one of the key areas of future research that can elucidate how genomes work. It combines genetics and the environment to address complex biological systems such as the plasticity of our genome. While all nucleated human cells carry the same genome, they express different genes at different times. Much of this is governed by epigenetic changes resulting in differential methylation of our genome--or different epigenomes. Individual studies over the past decades have already established the involvement of DNA methylation in imprinting, gene regulation, chromatin structure, genome stability and disease, especially cancer. Now, in the wake of the Human Genome Project (HGP), epigenetic phenomena can be studied genome-wide and are giving rise to a new field, epigenomics. Here, we review the current and future potential of this field and introduce the pilot study towards the Human Epigenome Project (HEP).
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References 212 · Cited by 150
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- Authors
- Novik, K. L., Nimmrich, I., Genc, B., Maier, S., Piepenbrock, C., Olek, A., & Beck, S.
- Affiliations
- Wellcome Sanger Institute (GB)
- Venue
- Current Issues in Molecular Biology
- Publisher
- MDPI AG
- Published
- 2002
- Volume
- 4
- Issue
- 4
- Pages
- 111-28
- ISSN
- 1467-3037 (ISSN-L)
- OpenAlex
- W172872761
- Cited by
- 150
- References
- 212
- Citations by year
- 2025: 4 · 2024: 8 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 6 · 2015: 5 · 2014: 5 · 2013: 4 · 2012: 10
- FWCI
- 4.86
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Current Issues in Molecular Biology (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust
- European Commission
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Keywords
- epigenomics, DNA methylation, epigenetics, genomic imprinting, gene expression regulation, chromatin structure, genome stability, cancer
- MeSH terms
- Autoimmune Diseases, Chromosome Mapping, Cytosine, Gene Expression Regulation, Humans, Major Histocompatibility Complex, Neoplasms, DNA Modification Methylases, Genome, Human, Human Genome Project, CpG Islands, DNA Methylation, Oligonucleotide Array Sequence Analysis
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