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Effects of Oral and Topical Application of Centella asiatica Extracts on The UVB-Induced Photoaging of Hairless Rats
Open accessAbstract
Chronic exposure to UVB irradiation can caused premature skin aging (photoaging), as it can trigger the production of ROS and initiate both oxidative stress in cell membrane and affect the molecular pathway. This paper figured out the potential of oral and topical administration of C. asiatica extract on hairless rats skin tissue exposed by UVB based on expression of TGF-β1, MMP-1 and MDA dermis. A total of 30 male-hairless rats (Rattus novergicus) divided into 6 experimental groups, exposed by UVB with total dose 840 mJ/cm2 for four weeks. Topical gel therapy administered twice a day, 20 minutes before and 4 hours after irradiation. Oral therapy administered once a day before irradiation. Expression of TGF-β1, MMP-1 and MDA dermis observed by immunohistochemistry. The result showed that oral and topical therapy of C. asiatica extract was capable of inhibiting the increase of MMP-1 and MDA expression and the decrease of TGF- β1 significantly (p<0.05) in the dermal fibroblast of Wistar rat that exposed UVB light.
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“The results demonstrate that both oral and topical application of C. asiatica extracts can help prevent photoaging by reducing wrinkle formation, skin thickness, and oxidative damage in hairless rats exposed to UVB radiation.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [38]
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“The researchers conducted a well‐designed experiment with clear methodology and statistical analysis, providing a moderate level of evidence according to the Oxford's Centre for Evidence‐Based Medicine.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [38]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“Furthermore, Rahmawati et al. [32] also observed that oral and topical C. asiatica extract reduced UVB-induced dermal MMP-1 activity and preserved skin structure in hairless rats.”
From Oral Centella asiatica Extract Attenuates UVB-Induced Skin Photoaging via Antioxidant, Anti-Inflammatory, and Extracellular Matrix-Preserving Effects in Hairless Mice (2025) · cites this paper as [32]
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“In vivo, Rahmawati et al. [32] observed that C. asiatica extract lowered MMP-1 and inflammatory cytokines in UVB-irradiated skin tissues, further supporting its systemic anti-inflammatory potential.”
From Oral Centella asiatica Extract Attenuates UVB-Induced Skin Photoaging via Antioxidant, Anti-Inflammatory, and Extracellular Matrix-Preserving Effects in Hairless Mice (2025) · cites this paper as [32]
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Cited by
Sorted by citations
Apiaceae as an Important Source of Antioxidants and Their Applications
Thiviya, P., Gamage, A., Arachchige, D., Merah, O., & Madhujith, T. (2021) · Cosmetics · doi:10.3390/cosmetics8040111 · Cited by 96
Cosmeceuticals in photoaging: A review.
Chan, L. K. W., Lee, K. W. A., Lee, C. H., Lam, K. W. P., Lee, K. F. V., Wu, R., Wan, J., Shivananjappa, S., Sky, W. T. H., Choi, H., et al. (2024) · Skin Research and Technology · doi:10.1111/srt.13730 · Cited by 23
Sundar, M., & Lingakumar, K. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e19161 · Cited by 8
Anti-aging activity of tetrahydrocurcumin, Centella asiatica extract, and its mixture
Astuti, I. Y., Yupitawati, A., & Nurulita, N. A. (2021) · Oriental Pharmacy and Experimental Medicine · doi:10.1007/s13596-020-00532-9 · Cited by 9
Choi, Y. J., Cho, E.-C., Lim, S., Lee, J., Bae, J., Oh, T. K., Lee, J. K., & Kim, E. J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010204 · Cited by 3
“Furthermore, Rahmawati et al. [32] also observed that oral and topical C. asiatica extract reduced UVB-induced dermal MMP-1 activity and preserved skin structure in hairless rats.”
Metadata
- Authors
- Chemistry Department, U. O. B., D. Rahmawati, Y., Aulanni’am, A., Laboratory of Biochemistry, C. D., Faculty of Veterinary Medicine, U. O. B., Prasetyawan, S., & Laboratory of Biochemistry, C. D.
- Affiliations
- University of Brawijaya (ID)
- Venue
- The Journal of Pure and Applied Chemistry Research
- Publisher
- Brawijaya University
- Published
- 2019-04-18
- Volume
- 8
- Issue
- 1
- Pages
- 7-14
- ISSN
- 2302-4690 (ISSN-L)
- 2541-0733
- OpenAlex
- W2911389828
- Cited by
- 5
- References
- 2
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2021: 2
- FWCI
- 0.51
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- The Journal of Pure and Applied Chemistry Research (publishedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- Centella asiatica, photoaging, UVB irradiation, topical gel, oral administration, TGF-β1, MMP-1, malondialdehyde, oxidative stress, dermal fibroblasts, skin aging, hairless rats
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- Chemistry Department, U. O. B., D. Rahmawati, Y., Aulanni’am, A., Laboratory of Biochemistry, C. D., Faculty of Veterinary Medicine, U. O. B., Prasetyawan, S., & Laboratory of Biochemistry, C. D. (2019). Effects of Oral and Topical Application of Centella asiatica Extracts on The UVB-Induced Photoaging of Hairless Rats. The Journal of Pure and Applied Chemistry Research. https://doi.org/10.21776/ub.jpacr.2019.008.01.430
