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Spontaneous Diabetes Produced by Selective Breeding of Normal Wistar Rats
Open accessAbstract
The present study was undertaken to see the possibility of production of spontaneous diabetes rat by repeating the selective breeding of normal rats with a slight impairment of glucose tolerance. One hundred and thirty male and 81 female normal rats of Wistar strain were obtained from an experimental animal farm as foundation stock and 9 male and 9 female rats were chosen as breeding stock by oral glucose tolerance test. By the crossing, 89 male and 73 female rats were obtained (F1). The mean glucose tolerance curve of these offsprings was significantly higher than that of the foundation stock. Twelve male and 13 female rats were chosen among the F1 rats as breeding stock by glucose tolerance test. The crossing of them yielded 116 male and 88 female rats (F2). The mean glucose tolerance curve of F2 was significantly higher than that of F1 and some of them had a diabetic test and a positive test for urine sugar during the test. The result demonstrated the possibility of production of spontaneous diabetes from normal rats by the selective breeding.
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Cited by
Ramalho-Santos, J., Amaral, S., & Oliveira, P. (2008) · Current Diabetes Reviews · doi:10.2174/157339908783502398 · Cited by 359
Consequences of Fetal Exposure to Maternal Diabetes in Offspring
Fetita, L.-S., Sobngwi, E., Serradas, P., Calvo, F., & Gautier, J.-F. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0624 · Cited by 299
Farris, W., Mansourian, S., Leissring, M. A., Eckman, E. A., Bertram, L., Eckman, C. B., Tanzi, R. E., & Selkoe, D. J. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63229-4 · Cited by 269
Ostenson, C.-G., Gaisano, H., Sheu, L., Tibell, A., & Bartfai, T. (2006) · Diabetes · doi:10.2337/diabetes.55.02.06.db04-1575 · Cited by 232
Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats
Fakhrai-Rad, H. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.14.2149 · Cited by 155
Metadata
- Authors
- GOTO, Y., KAKIZAKI, M., & MASAKI, N.
- Venue
- Proceedings of the Japan Academy
- Publisher
- Japan Academy
- Published
- 1975
- Volume
- 51
- Issue
- 1
- Pages
- 80-85
- ISSN
- 0021-4280 (ISSN-L)
- OpenAlex
- W2181081363
- Cited by
- 269
- References
- 0
- FWCI
- 1.48
- Type
- journal article
- Language
- en
- Open access
- diamond
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- GOTO, Y., KAKIZAKI, M., & MASAKI, N. (1975). Spontaneous Diabetes Produced by Selective Breeding of Normal Wistar Rats. Proceedings of the Japan Academy. https://doi.org/10.2183/pjab1945.51.80
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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