A Therapeutic Relational Agent for Reducing Problematic Substance Use (Woebot): Development and Usability Study

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1. Exploring AI in Healthcare Systems: A Study of Medical Applications and a Proposal for a Smart Clinical Assistant
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2. AI-Enabled Personalized Smoking Cessation Intervention With the Aipaca Chatbot: Mixed Methods Feasibility Study
   Yunlong Liu, Paul Calle, Mariah Vadakekut, Daniel A. Rubin, Zsolt J. Nagykaldi, Mark Philip Doescher, Lisa Hightow‐Weidman, Chongle Pan, Ruosi Shao · 2025 · JMIR Formative Research
3. Conversational agents on smartphones and the web
   Timothy Bickmore, Teresa K. O’Leary · 2022 · Elsevier eBooks
4. Conversational Artificial Intelligence: Changing Tomorrow’s Health Care Today
   Mark Campbell, Mladjan Jovanovic · 2021 · Computer
5. Healthcare delivery in the arctic-telehealth prospects
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6. Ethical Considerations Surrounding the Use of AI-Interventions in Application of Mental Healthcare
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7. Revolutionizing Mental Healthcare Through Artificial Intelligence
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8. Echoes of Empathy: A Symbiotic IoT-Based Emotion Feedback Framework for Psychological Interventions via Large Language Model
   Minqiang Yang, Zhichao Yang, Zhaolong Ning, Hao Shen, Chengsheng Mao, Changsheng Ma, Bin Hu · 2025 · IEEE Internet of Things Journal
9. Bridging Technology and Pretest Genetic Services: Quantitative Study of Chatbot Interaction Patterns, User Characteristics, and Genetic Testing Decisions
   Yang Yi, Lauren Kaiser‐Jackson, Jemar R. Bather, Melody S. Goodman, Daniel Chavez‐Yenter, Richard L. Bradshaw, Rachelle Lorenz Chambers, Whitney Espinel, Rachel Hess, Devin M Mann et al. · 2025 · Journal of Medical Internet Research
10. A relational agent for treating substance use in adults: Protocol for a randomized controlled trial with a psychoeducational comparator
    Judith J. Prochaska, Erin A. Vogel, Amy Chieng, Michael Baiocchi, Sarah Pajarito, Maddison Pirner, Alison M. Darcy, Athena Hagler Robinson · 2023 · Contemporary Clinical Trials
11. Do You Ever Get Off Track in a Conversation? The Conversational System’s Anatomy and Evaluation Metrics
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12. Impact of artificial intelligence on healthcare
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13. Attitudes towards AI counseling: the existence of perceptual fear in affecting perceived chatbot support quality
    Wing Man Keung, Tsz Yan So · 2025 · Frontiers in Psychology
14. Smartphone-Based Digital Health Interventions: A Comprehensive Systematic Review of Efficacy for Cardiovascular and Cerebrovascular Outcomes
    Swathi Suresh, Sujas Bhardwaj, Hansel Chris Rodrigues, Dhanya Charly, Tufayl Ahmed Mohammed Shekha, Angeline Jessy, Anupa Anirudhan, M L Abhishek, Thomas Gregor Issac · 2025 · Journal of Medical Systems
15. The future of personalized learning with AI
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16. Digital transformation of mental health therapy by integrating digitalized cognitive behavioral therapy and eye movement desensitization and reprocessing
    Ju‐Yu Wu, Ying-Ying Tsai, Yu-Jie Chen, Fan‐Chi Hsiao, Ching‐Han Hsu, Kuang Lin, Lun‐De Liao · 2024 · Medical & Biological Engineering & Computing
17. Therapy as an NLP Task: Comparing LLMs and Human Peers Behaviors in CBT Sessions
    Iftikhar, Zainab, Ransom, Sean, Xiao, Amy, Nugent, Nicole, Huang, Jeff · 2024 · arXiv
18. Deconstructing Depression Stigma: Integrating AI-driven Data Collection and Analysis with Causal Knowledge Graphs
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19. How do users of a mental health app conceptualise digital therapeutic alliance? A qualitative study using the framework approach
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20. Give and Take: Perceptions of a Conversational Coach Agent in Fitness Trackers MHCI014
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21. SMART-DREAM: To Condition or Not to Condition; A Study on the Impact of LLM Conditioning on Motivational Interview Dialog Virtual Agent
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22. Therapy as an NLP Task: Comparing LLMs and Human Peers Behaviors in CBT Sessions
    Zainab Iftikhar, Sean Ransom, Amy Wei Xiao, Nicole R. Nugent, Jeff J. S. Huang · 2026 · Proceedings of the ACM on Human-Computer Interaction
23. Are Large Language Models Possible to Conduct Cognitive Behavioral Therapy?
    Hao Shen, Zihan Li, Minqiang Yang, Minghui Ni, Yongfeng Tao, Zhengyang Yu, Weihao Zheng, Xu Chen, Bin Hu · 2024 · IEEE International Conference on Bioinformatics and Biomedicine (BIBM)
24. Exploring the Challenges and Opportunities in Developing Systems to Improve Alcohol Use Disorder through Chatbot Technology
    Xiang-Zhi Qiu, Chien Wen Yuan, Nanyi Bi, Ming‐Chyi Huang, Chuang-Wen You · 2023 · CHI Conference Extended Abstracts on Human Factors in Computing Systems (CHI EA)
25. Democratizing the Development of Chatbots to Improve Public Health: Feasibility Study of COVID-19 Misinformation
    Leigh Powell, Radwa Nour, Randa Sleibi, Hanan Sulaiman Al Suwaidi, Nabil Zary · 2023 · JMIR Human Factors
26. On safe and usable chatbots for promoting voter participation
    Bharath Chandra Muppasani, Vishal Pallagani, Kausik Lakkaraju, Shuge Lei, Biplav Srivastava, Brett W. Robertson, Andrea Hickerson, Vignesh Narayanan · 2023 · AI Magazine
27. Conversational Agents in Healthcare: A Variability Perspective
    Richard May, Kerstin Denecke · 2024 · International Workshop on Variability Modelling of Software-Intensive Systems (VaMoS)
28. On the Pragmatics of the Turing Test
    Baptiste Jacquet, Frank Jamet, Jean Baratgin · 2021 · International Conference on Information and Digital Technologies (IDT)
29. Toward an Ethic of Synthetic Relationality: Identity, Intimacy, and Risk in AI-Mediated Roleplay Environments
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30. AI Integration in Behavioral Healthcare: A Practical Framework for Clinicians
    Shiri Sadeh‐Sharvit, Steven D. Hollon · 2025 · Journal of Technology in Behavioral Science
31. AI-Enabled, Text-Based Health Coaching and Navigation for Employees to Support Health Outcomes: Pre-Post Observational Study
    Paula L. Wilbourne, Susan Mirch-Kretschmann, Denise D. Walker, Michael Varghese, Roberto Arnetoli · 2025 · JMIR Formative Research
32. A counselor-inspired agent framework for AI counselors to enhance client engagement
    Yuanrong Tang, Yu Kang, Yifan Wang, T. Y. Wang, Chen Zhong, Jiangtao Gong · 2025 · Technology in Society
33. The dangers of AI friendship: Adolescent mental health and ethical oversight
    Harshit Katoch, Damanjit Sandhu · 2025 · Elsevier eBooks
34. Effect of AI-Based Natural Language Feedback on Engagement and Clinical Outcomes in Fully Self-Guided Internet-Based Cognitive Behavioral Therapy for Depression: 3-Arm Randomized Controlled Trial
    Mirai So, Yoichi Sekizawa, Sora Hashimoto, Masami Kashimura, Hajime Yamakage, Norio Watanabe · 2025 · Journal of Medical Internet Research
35. Evaluation of an Artificial Intelligence Conversational Chatbot to Enhance HIV Preexposure Prophylaxis Uptake: Development and Usability Internal Testing
    Jun Tao, Ellie Pavlick, Amaris Grondin, Josue D Bustamante, Harrison Martin, Hannah Parent, Natalie Q. Fenn, Alexi A Almonte, Amanda Maguire-Wilkerson, Mofan Gu et al. · 2025 · Journal of Medical Internet Research
36. The Use of Artificial Intelligence for Personalized Treatment in Psychiatry
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37. Analyzing the Role of Health Apps in Promoting Healthy Lifestyle and Preventive Care
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38. Application of Digital Medicine in Addiction
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39. Customized Training of Pretrained Language Models to Detect Post Intents in Online Health Support Groups
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40. Ethical Aspects of Faking Emotions in Chatbots and Social Robots*
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41. TherapyBot: a chatbot for mental well-being using transformers
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42. MindLift – A Conversational AI Chatbot for Enhancing Mental Health
    Sandesh Dolas, Saurabh Pendam, Umakant Kulkarni, Archana S. Kadam · 2024 · MIT Art, Design and Technology School of Computing International Conference (MITADTSoCiCon)
43. Examining the Effects of Cognitive Behavioral Therapy With a Virtual Agent on User Motivation and Improvement in Psychological Distress and Anxiety: Two-Session Experimental Study
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44. Machine Learning and Artificial Intelligence in Modern Medicine
    Parham Rahmani, Parham Mortazavi, Hamid Reza Aghaei Meybodi, George P. Patrinos, Negar Sarhangi, Shekoufeh Nikfar, Bagher A. Larijani, Nazli Khodayari, Mandana Hasanzad · 2024 · Springer eBooks
45. A scoping review on the mental health harms of LLM-based chatbots
    Diel, Alexander, Torous, John, Cuijpers, Pim, Kleesiek, Jens, Nensa, Felix, Weber, Niels, Faust, Franziska, Lalgi, Tania Josan, Mellis, Finley Sam, Teufel, Martin et al. · 2026 · npj Digital Medicine
46. Artificial Continuing Bonds: A Proposed Framework for Responsible Integration of Generative AI in Clinical Thanatology
    Alexander Manevich, Shani Aluma · 2025 · OMEGA - Journal of Death and Dying
47. Artificial Intelligence Technologies in Mental Health
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48. Leveraging artificial intelligence-mediated communication for cancer prevention and control and drug addiction: A systematic review
    Sunny Jung Kim, Viktor Clark, Jeffrey T. Hancock, Reza Rawassizadeh, Hongfang Liu, Emmanuel A. Taylor, Vanessa B. Sheppard · 2025 · Translational Behavioral Medicine
49. An overview of the applied use of chatbots for substance use disorder: Past, present and future
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50. Chatbots as Tools for Psychoeducation and Self-Help in Mental Health
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51. Theory of Mind in Artificial Intelligence Applications
    Alvaro Garcia-Lopez · 2023 · Logic, argumentation & reasoning
52. Implementation of Anxiety UK’s Ask Anxia Chatbot Service: Lessons Learned
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53. Mental Wellness Assistant using Retrieval-Augmented Generation (RAG)
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54. A Scoping Review of Large Language Model Chatbot Use for Alcohol and Other Drug Health Information
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55. User-AI intimacy in digital health
    Runyu Shi, Dimitra Petrakaki · 2025 · Social Science & Medicine
56. Commercial AI-Based Mental Health Chatbots as Low-Intensity Adjuncts to Psychotherapy: Effectiveness, Adherence, and Safety – A Systematic Review and Meta-Analysis
    Hongyi Yang, Fangyuan Chang, Fumie Muroi, Zhao Liu, Weibo Zhang, Jun Cai · 2026 · Psychotherapy and Psychosomatics
57. Clinical Applications of AI in Post-Cancer Rehabilitation
    Mayyas M. Al-Remawi, Faisal Asad Farid Aburub · 2024 · International Conference on Cyber Resilience (ICCR)
58. Robots and Social Sustainability
    Bipin Indurkhya, Barbara Sienkiewicz · 2024 · Springer proceedings in advanced robotics
59. Needs-Assessment for an Artificial Intelligence-Based Chatbot for Pharmacists in HIV Care: Results from a Knowledge–Attitudes–Practices Survey
    Moustafa A. Laymouna, Yuanchao Ma, David Lessard, Kim Engler, Rachel Therrien, Tibor Schuster, Serge Vicente, Sofiane Achiche, Maria Nait El Haj, Benoît Lemire et al. · 2024 · Healthcare
60. Overview of chatbot usage on mental health: A scoping review
    Ririn Indah Permatasari, Dian Parama Artha, Bayu Satria Wiratama, Hanifah Wulandari · 2024 · BIO Web of Conferences
61. The impact of social media on mental health
    Atina Ndindeng · 2025 · Mental Health and Digital Technologies
62. RACares: a conceptual design to guide mHealth relational agent development based on a systematic review
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63. Prevention of Alcohol-Associated Liver Disease
    Robyn Burton, Lorenzo Leggio, Alexandre Louvet, Nick Sheron, Ashwani Kumar Singal · 2025 · The American Journal of Gastroenterology
64. IoTMindCare: An Integrative Reference Architecture for Safe and Personalized IoT-Based Depression Management
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65. Artificial intelligence robots for mental health applications: a scoping review
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66. Therapeutic Interaction Features of AI Chatbots in Depression Interventions: Systematic Review and Meta-Analysis
    Ting Huang, Shuangyu Li, Yanzhong Wang, Wei Liu · 2026 · Journal of Medical Internet Research
67. Beyond calories: evaluating how tailored communication reduces emotional load in diet-coaching
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68. From Bytes to Insights: The Promise and Peril of Artificial Intelligence–Powered Psychiatry
    Alex Luna, Steven E. Hyler · 2024 · Academic Psychiatry
69. Aplicação da Inteligência Artificial em transtornos mentais: uma revisão sistemática
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70. Conversational Agent Utilization Patterns of Individuals with Autism Spectrum Disorder
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71. Exploring the impacts of implicit context association and arithmetic booster in impulsivity reduction
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72. Experiences on Creating Personal Study Plans with Chatbots
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73. Acceptability and effectiveness of a chatbot for delivering Cognitive Behavioral Therapy (CBT) to adolescents with depression and anxiety during the COVID-19 pandemic (Preprint)
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74. Proceedings of the 2nd Workshop on Human Evaluation of NLP Systems (HumEval)
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77. Using Penalized Synthetic Controls on Truncated Data: A Case Study on Effect of Marijuana Legalization on Direct Payments to Physicians by Opioid Manufacturers
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78. Harnessing Generative AI for Enhanced Learning in Moroccan Education: A Case Study Investigation
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79. Woebot for Postpartum Mood and Anxiety: Randomized Controlled Trial Evaluating Feasibility, Acceptability, and Preliminary Efficacy of a Mobile Cognitive Behavioral Therapy Intervention
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80. Are Strength-Related Episodes Provided by Others Useful for Improving Positive Emotions? Toward the Design of a Computer-Based Self-Esteem Enhancement System
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81. HealthInsights: An Online Conversational Survey for Understanding Worker Health in Crowdsourcing Platforms
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82. Generative AI in Mental Well-Being: Balancing Pros and Cons
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83. Web-based multimodal learning system to develop social communication skills
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84. Prevalence of Dropout and Influencing Factors in Digital Psychosocial Intervention Trials for Adult Illicit Substance Users: Systematic Review and Meta-Analysis
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85. AI-Based Chatbots for Mental Health: Comparative Study
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88. Mechanisms, Effectiveness, and Evolution of Technology-based Interventions in Addiction Treatment
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91. Artificial Empathy: Evaluating AI Emotional Support Systems in Organizations
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