Extent of MRI delayed enhancement of myocardial mass is related to right ventricular dysfunction in pulmonary artery hypertension
Abstract
Objective The purpose of our study was to assess the presence and extent of delayed contrast enhancement of ventricular myocardium in pulmonary artery hypertension. Subjects and methods Fifteen patients (age, 45.6 +/- 13 years; 13 New York Heart Association class III) with pulmonary artery hypertension (11 idiopathic, four systemic sclerosis) were studied. All patients had undergone a comprehensive diagnostic workup, and pulmonary artery hypertension (mean pulmonary artery pressure, 54 +/- 16 mm Hg) was confirmed by cardiac catheterization. Cardiac MRI was performed on a 1.5-T scanner to determine ventricular volumes and mass. Delayed contrast enhancement of a mass was seen 10-20 minutes after the i.v. injection of 0.2 mmol/kg of gadopentetate dimeglumine using an inversion recovery gradient-echo sequence. Results All patients showed delayed contrast enhancement at the insertion points of the right ventricular free wall to the interventricular septum (15 inferior, 13 anterior). The mean weight of the delayed contrast-enhanced myocardial mass was 3.1 +/- 1.9 g (size range, 0.3-3.9% of the total myocardial mass). The extent of the delayed contrast-enhancing myocardium was inversely related to the right ventricular ejection fraction (r = -0.63, p = 0.001), right ventricular stroke volume (r = -0.67, p = 0.006), and right ventricular end-systolic volume index (r = -0.51, p = 0.05) but not to any invasively measured hemodynamic index or N-terminal pro brain natriuretic peptide. Co…
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The pattern of focal DGE in athletes is similar to the pattern described in patients with pulmonary hypertension.
“This is similar to the pattern described in patients with pulmonary hypertension in whom increased interventricular wall stress caused through chronic RV pressure overload may cause disruption to the muscle bundle architecture and/or expansion of the interstitial matrix at this site.25,33”
From Exercise-induced right ventricular dysfunction and structural remodelling in endurance athletes (2012) · cites this paper as [33]
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References 39 · Cited by 147
- Authors
- McCann, G. P., Gan, C. T., Beek, A. M., Niessen, H. W. M., Noordegraaf, A. V., & van Rossum, A. C.
- Affiliations
- Glenfield Hospital (GB)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Present address: Department of Cardiology, Glenfield Hospital, Groby Rd., Leicester LE3 9QP, United Kingdom.
- Venue
- American Journal of Roentgenology
- Publisher
- American Roentgen Ray Society
- Published
- 2007-02
- Volume
- 188
- Issue
- 2
- Pages
- 349-355
- ISSN
- 0002-9580 (ISSN-L)
- 0361-803X
- 1546-3141
- OpenAlex
- W1974878968
- Cited by
- 147
- References
- 39
- Citations by year
- 2026: 4 · 2024: 2 · 2023: 2 · 2022: 8 · 2021: 7 · 2020: 6 · 2019: 9 · 2018: 7 · 2017: 11 · 2016: 5 · 2015: 8 · 2014: 15 · 2013: 15 · 2012: 19
- FWCI
- 5.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Roentgenology (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- European Society of Cardiology
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Keywords
- pulmonary arterial hypertension, delayed contrast enhancement, myocardial mass, right ventricular dysfunction, right ventricular ejection fraction, right ventricular stroke volume, right ventricular end-systolic volume, systemic sclerosis, Gd-DTPA, cardiac MRI, myocardial fibrosis
- MeSH terms
- Contrast Media, Drug Administration Schedule, Female, Heart Ventricles, Humans, Hypertension, Pulmonary, Image Enhancement, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Organ Size, Pulmonary Artery, Sensitivity and Specificity, Reproducibility of Results, Ventricular Dysfunction, Right, Gadolinium DTPA, Imaging, Three-Dimensional
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