Imaging of adrenal tumors using FDG PET: comparison of benign and malignant lesions
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OBJECTIVE: The aim of this study was to differentiate benign from malignant adrenal tumors using positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) in patients with unilateral adrenal masses originally detected by CT or MR imaging. CONCLUSION: PET imaging with FDG can metabolically characterize adrenal masses. Abnormally increased FDG uptake in adrenal malignancies allows one to differentiate these abnormalities from benign lesions. Whole-body PET can also reveal extraadrenal tumor sites in patients with malignant tumors, using a single imaging technique for accurate disease staging.
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Benign adrenal lesions, particularly functional adenomas and nonmetastatic pheochromocytomas, can be FDG positive.
“One limitation is that benign adrenal lesions particularly functional adenomas and nonmetastatic pheochromocytomas can be FDG positive (313,314).”
From Adrenal incidentaloma (2020) · cites this paper as [313]
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References 11 · Cited by 159
Research works printed but not linked: 1
- Gross MD, Shapiro B. Clinical review 50: clini-
- Authors
- Maurea, S., Mainolfi, C., Bazzicalupo, L., Panico, M. R., Imparato, C., Alfano, B., Ziviello, M., & Salvatore, M.
- Affiliations
- University of Naples Federico II (IT)
- Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Venue
- American Journal of Roentgenology
- Publisher
- American Roentgen Ray Society
- Published
- 1999-07
- Volume
- 173
- Issue
- 1
- Pages
- 25-29
- ISSN
- 0002-9580 (ISSN-L)
- 0361-803X
- 1546-3141
- OpenAlex
- W2145251853
- Cited by
- 159
- References
- 11
- Citations by year
- 2024: 1 · 2022: 5 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 4 · 2015: 2 · 2014: 3 · 2013: 5 · 2012: 7
- FWCI
- 6.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Roentgenology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Consiglio Nazionale delle Ricerche
- Topics
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Health Sciences › Medicine › Epidemiology › Neuroendocrine Tumor Research Advances
- Keywords
- adrenal tumors, adrenal mass, FDG-PET, 18F-fluorodeoxyglucose, benign versus malignant differentiation, cancer metabolism, disease staging, adrenal cancer
- MeSH terms
- Adolescent, Adrenal Gland Neoplasms, Adult, Aged, Diagnosis, Differential, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Tomography, Emission-Computed, Tomography, X-Ray Computed, Radiopharmaceuticals, Fluorodeoxyglucose F18
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