Antioxidant and Anticancer Potential of Raja Bulu Banana Peel and Heart (Musa acuminata Colla (AAB group)) Ethanol Extracts in MCF-7 Cell Lines
Open accessAbstract
Breast cancer is an uncontrolled cell growth in breast tissue. Surgical treatments of breast cancer can reduce breast aesthetics and chemotherapy can cause severe side effects. It makes the searches for plants as breast anticancer agents intensively carried out. Several studies have shown that banana peels and hearts possess antioxidant and anticancer activity. This study aims to determine the fruit peel and heart of Raja Bulu banana (Musa acuminata Colla (AAB group)), an endemic banana species in Indonesia, potential as antioxidant and anticancer agent in MCF-7 cells. Antioxidant potential was determined by using 2,2-diphenyl-1picrylhydrazyl (DPPH) and hydrogen peroxide (H2O2) scavenging activity assay. Anticancer potential was determined by cytotoxic test using MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium). The results showed that 70% ethanol extract of fruit peel (PBEE) and heart (HBEE) of Raja Bulu banana had median inhibition concentration (IC50) for DPPH scavenging activity at 115.32 µg/mL and 162.52 µg/mL respectively, while for H2O2 scavenging activity at 624.80 µg/mL and 497.13 µg/mL respectively. Anticancer potential was expressed by inhibiting concentration of 50% proliferation (IC50) of MCF-7 cells for PBEE and HBEE were 115.001 µg/mL and 338.469 µg/mL respectively. This study showed that PBEE and HBEE have antioxidant and anticancer.
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The extraction yield of 9.13% is moderate and slightly below optimal yields (>10%) reported in previous studies.
“The extraction yield was calculated to be 9.13%, indicating a moderate extraction efficiency that is slightly below the optimal yields (>10%) reported in previous studies (Sutjiatmo et al., 2021).”
From Antioxidant Activity of Ethanol Extract Combination of Cavendis Banana Peel (Musa acuminata) and Kepok Banana Peel (Musa paradisiaca) Using the DPPH Method (2025) · cites this paper as Sutjiatmo et al., 2021
Species, environmental growth conditions, and extraction methods influence phytochemical profiles and antioxidant potency.
“Sutjiatmo et al. (2021) again demonstrated moderate activity in Raja Bulu peel, while Wijaya et al. (2023) found stronger antioxidant effects in Kedondong leaf extracts, emphasizing that species, environmental growth conditions, and extraction methods influence phytochemical profiles and antioxidant potency.”
From Antioxidant Activity of Ethanol Extract Combination of Cavendis Banana Peel (Musa acuminata) and Kepok Banana Peel (Musa paradisiaca) Using the DPPH Method (2025) · cites this paper as Sutjiatmo et al. (2021)
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Suhada, A., Ulya, T., Fardani, R. A., Pertiwi, A. D., Halid, I., Pauzan, P., Ratulangi, W. R., Indriani, N., Ariwidiani, N. N., Widyan, R., et al. (2025) · Prisma Sains : Jurnal Pengkajian Ilmu dan Pembelajaran Matematika dan IPA IKIP Mataram · doi:10.33394/j-ps.v13i3.15782
- Authors
- Sutjiatmo, A. B., Widowati, W., Sumiati, I., Priestu, T., Arumwardana, S., Kusuma, H. S. W., & Azizah, A. M.
- Affiliations
- Universitas Jenderal Achmad Yani (ID)
- Maranatha Christian University (ID)
- Corresponding author
- Widowati, Wahyu
- ORCID
- Venue
- Majalah Obat Tradisional
- Publisher
- Universitas Gadjah Mada
- Published
- 2021-04-07
- Volume
- 26
- Issue
- 1
- Pages
- 49
- ISSN
- 1410-5918 (ISSN-L)
- 2406-9086
- OpenAlex
- W3153241423
- Cited by
- 8
- References
- 0
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 1
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Majalah Obat Tradisional (publishedVersion, cc-by)
- Majalah Obat Tradisional (publishedVersion, cc-by-nc-nd)
- Indonesian Journal of Biotechnology (Universitas Gadjah Mada) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
- Keywords
- Musa acuminata, banana peel, banana heart, antioxidant activity, anticancer activity, breast cancer, MCF-7 cells, DPPH radical scavenging, hydrogen peroxide scavenging, cytotoxicity, ethanol extract, medicinal plants
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