The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Aspects of Immune Dysfunction in End-stage Renal Disease
Open accessAbstract
End-stage renal disease (ESRD) is associated with significantly increased morbidity and mortality resulting from cardiovascular disease (CVD) and infections, accounting for 50% and 20%, respectively, of the total mortality in ESRD patients. It is possible that these two complications are linked to alterations in the immune system in ESRD, as uremia is associated with a state of immune dysfunction characterized by immunodepression that contributes to the high prevalence of infections among these patients, as well as by immunoactivation resulting in inflammation that may contribute to CVD. This review describes disorders of the innate and adaptive immune systems in ESRD, underlining the specific role of ESRD-associated disturbances of Toll-like receptors. Finally, based on the emerging links between the alterations of immune system, CVD, and infections in ESRD patients, it emphasizes the potential role of the immune dysfunction in ESRD as an underlying cause for the high mortality in this patient population and the need for more studies in this area.
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Cites
Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394
Delves, P. J., & Roitt, I. M. (2000) · New England Journal of Medicine · doi:10.1056/nejm200007063430107 · Cited by 1,666
Cited by
Cardiovascular and noncardiovascular mortality among patients starting dialysis
de Jager, D. J. (2009) · JAMA · doi:10.1001/jama.2009.1488 · Cited by 755
Heart failure and kidney dysfunction: epidemiology, mechanisms and management
Schefold, J. C., Filippatos, G., Hasenfuss, G., Anker, S. D., & von Haehling, S. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.113 · Cited by 671
Immune cell dysfunction and inflammation in end-stage renal disease
Betjes, M. G. H. (2013) · Nature Reviews Nephrology · doi:10.1038/nrneph.2013.44 · Cited by 542
The intestinal microbiota, a leaky gut, and abnormal immunity in kidney disease
Anders, H.-J., Andersen, K., & Stecher, B. (2013) · Kidney International · doi:10.1038/ki.2012.440 · Cited by 493
Immune Dysfunction and Risk of Infection in Chronic Kidney Disease
Syed-Ahmed, M., & Narayanan, M. (2019) · Advances in Chronic Kidney Disease · doi:10.1053/j.ackd.2019.01.004 · Cited by 411
Metadata
- Authors
- Kato, S., Chmielewski, M., Honda, H., Pecoits-Filho, R., Matsuo, S., Yuzawa, Y., Tranaeus, A., Stenvinkel, P., & Lindholm, B.
- Venue
- Clinical Journal of the American Society of Nephrology
- Published
- 2008-09
- Volume
- 3
- Issue
- 5
- Pages
- 1526-1533
- ISSN
- 1555-9041 (ISSN-L)
- OpenAlex
- W2104843066
- Cited by
- 1,087
- References
- 2
- FWCI
- 9.84
- Type
- journal article
- Language
- en
- Open access
- green
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- Kato, S., Chmielewski, M., Honda, H., Pecoits-Filho, R., Matsuo, S., Yuzawa, Y., Tranaeus, A., Stenvinkel, P., & Lindholm, B. (2008). Aspects of Immune Dysfunction in End-stage Renal Disease. Clinical Journal of the American Society of Nephrology. https://doi.org/10.2215/cjn.00950208
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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