The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Septic Acute Kidney Injury in Critically Ill Patients: Clinical Characteristics and Outcomes
Open accessAbstract
Sepsis is the most common cause of acute kidney injury (AKI) in critical illness, but there is limited information on septic AKI. A prospective, observational study of critically ill patients with septic and nonseptic AKI was performed from September 2000 to December 2001 at 54 hospitals in 23 countries. A total of 1753 patients were enrolled. Sepsis was considered the cause in 833 (47.5%); the predominant sources of sepsis were chest and abdominal (54.3%). Septic AKI was associated with greater aberrations in hemodynamics and laboratory parameters, greater severity of illness, and higher need for mechanical ventilation and vasoactive therapy. There was no difference in enrollment kidney function or in the proportion who received renal replacement therapy (RRT; 72 versus 71%; P = 0.83). Oliguria was more common in septic AKI (67 versus 57%; P < 0.001). Septic AKI had a higher in-hospital case-fatality rate compared with nonseptic AKI (70.2 versus 51.8%; P < 0.001). After adjustment for covariates, septic AKI remained associated with higher odds for death (1.48; 95% confidence interval 1.17 to 1.89; P = 0.001). Median (IQR) duration of hospital stay for survivors (37 [19 to 59] versus 21 [12 to 42] d; P < 0.0001) was longer for septic AKI. There was a trend to lower serum creatinine (106 [73 to 158] versus 121 [88 to 184] mumol/L; P = 0.01) and RRT dependence (9 versus 14%; P = 0.052) at hospital discharge for septic AKI. Patients with septic AKI were sicker and had a higher burden of illness and greater abnormalities in acute physiology. Patients with septic AKI had an increased risk for death and longer duration of hospitalization yet showed trends toward greater renal recovery and independence from RRT.
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Self-citation2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
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Cited by
Global epidemiology and outcomes of acute kidney injury
Hoste, E. A. J., Kellum, J. A., Selby, N. M., Zarbock, A., Palevsky, P. M., Bagshaw, S. M., Goldstein, S. L., Cerdá, J., & Chawla, L. S. (2018) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0052-0 · Cited by 1,486
Self-citationRoberts, J. A., Abdul-Aziz, M. H., Lipman, J., Mouton, J. W., Vinks, A. A., Felton, T. W., Hope, W. W., Farkas, A., Neely, M. N., Schentag, J. J., et al. (2014) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(14)70036-2 · Cited by 1,046
Sepsis associated acute kidney injury
Poston, J. T., & Koyner, J. L. (2019) · BMJ · doi:10.1136/bmj.k4891 · Cited by 818
Early acute kidney injury and sepsis: a multicentre evaluation
Bagshaw, S. M., George, C., Bellomo, R., & the ANZICS Database Management Committee (2008) · Critical Care · doi:10.1186/cc6863 · Cited by 685
Self-citationChakraborty, S., Kaur, S., Guha, S., & Batra, S. K. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.03.008 · Cited by 503
Metadata
- Authors
- Bagshaw, S. M., Uchino, S., Bellomo, R., Morimatsu, H., Morgera, S., Schetz, M., Tan, I., Bouman, C., Macedo, E., Gibney, N., Tolwani, A., Oudemans-van Straaten, H. M., Ronco, C., & Kellum, J. A.
- Venue
- Clinical Journal of the American Society of Nephrology
- Published
- 2007-05
- Volume
- 2
- Issue
- 3
- Pages
- 431-439
- ISSN
- 1555-9041 (ISSN-L)
- OpenAlex
- W2159437578
- Cited by
- 888
- References
- 40
- FWCI
- 13.68
- Type
- journal article
- Language
- en
- Open access
- green
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- Bagshaw, S. M., Uchino, S., Bellomo, R., Morimatsu, H., Morgera, S., Schetz, M., Tan, I., Bouman, C., Macedo, E., Gibney, N., Tolwani, A., Oudemans-van Straaten, H. M., Ronco, C., & Kellum, J. A. (2007). Septic Acute Kidney Injury in Critically Ill Patients: Clinical Characteristics and Outcomes. Clinical Journal of the American Society of Nephrology. https://doi.org/10.2215/cjn.03681106
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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