The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Nephrotoxicity and Chinese Herbal Medicine
Open accessAbstract
Chinese herbal medicine has been practiced for the prevention, treatment, and cure of diseases for thousands of years. Herbal medicine involves the use of natural compounds, which have relatively complex active ingredients with varying degrees of side effects. Some of these herbal medicines are known to cause nephrotoxicity, which can be overlooked by physicians and patients due to the belief that herbal medications are innocuous. Some of the nephrotoxic components from herbs are aristolochic acids and other plant alkaloids. In addition, anthraquinones, flavonoids, and glycosides from herbs also are known to cause kidney toxicity. The kidney manifestations of nephrotoxicity associated with herbal medicine include acute kidney injury, CKD, nephrolithiasis, rhabdomyolysis, Fanconi syndrome, and urothelial carcinoma. Several factors contribute to the nephrotoxicity of herbal medicines, including the intrinsic toxicity of herbs, incorrect processing or storage, adulteration, contamination by heavy metals, incorrect dosing, and interactions between herbal medicines and medications. The exact incidence of kidney injury due to nephrotoxic herbal medicine is not known. However, clinicians should consider herbal medicine use in patients with unexplained AKI or progressive CKD. In addition, exposure to herbal medicine containing aristolochic acid may increase risk for future uroepithelial cancers, and patients require appropriate postexposure screening.
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Cites
Urothelial Carcinoma Associated with the Use of a Chinese Herb (Aristolochia fangchi)
Nortier, J. L., Martinez, M.-C. M., Schmeiser, H. H., Arlt, V. M., Bieler, C. A., Petein, M., Depierreux, M. F., De Pauw, L., Abramowicz, D., Vereerstraeten, P., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200006083422301 · Cited by 983
UROTHELIAL CARCINOMA ASSOCIATED WITH THE USE OF A CHINESE HERB ( ARISTOLOCHIA FANGCHI )
Ortier, L. N., Arie, M., Chmeiser, H. S., Rlt, V. O. M. A., Ieler, H. A. B., Etein, M. I. P., Epierreux, M. I. F. D., Auw, L., Bramowicz, D. A. A., & Ereerstraeten, P. I. V. (2014) · Cited by 814
Aristolochic acid nephropathy: A worldwide problem
Debelle, F. D., Vanherweghem, J.-L., & Nortier, J. L. (2008) · Kidney International · doi:10.1038/ki.2008.129 · Cited by 763
De Smet, P. A. G. M. (2002) · New England Journal of Medicine · doi:10.1056/nejmra020398 · Cited by 525
Epidemiology and Clinical Correlates of AKI in Chinese Hospitalized Adults
Xu, X., Nie, S., Liu, Z., Chen, C., Xu, G., Zha, Y., Qian, J., Liu, B., Han, S., Xu, A., et al. (2015) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.02140215 · Cited by 330
Safety Surveillance of Traditional Chinese Medicine: Current and Future
Liu, S.-H., Chuang, W.-C., Lam, W., Jiang, Z., & Cheng, Y.-C. (2015) · Drug Safety · doi:10.1007/s40264-014-0250-z · Cited by 251
Isnard Bagnis, C., Deray, G., Baumelou, A., Le Quintrec, M., & Vanherweghem, J. L. (2004) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2004.02.009 · Cited by 244
Vanherweghem, J.-L. (1998) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.1998.4.1-9 · Cited by 225
Toxicological Risks of Chinese Herbs
Shaw, D. (2010) · Planta Medica · doi:10.1055/s-0030-1250533 · Cited by 189
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Cited by
KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease
Stevens, P. E., Ahmed, S. B., Carrero, J. J., Foster, B., Francis, A., Hall, R. K., Herrington, W. G., Hill, G., Inker, L. A., Kazancıoğlu, R., et al. (2024) · Kidney International · doi:10.1016/j.kint.2023.10.018 · Cited by 8,530
Chronic Kidney Disease Diagnosis and Management: A Review
Chen, T. K., Knicely, D. H., & Grams, M. E. (2019) · JAMA · doi:10.1001/jama.2019.14745 · Cited by 1,811
Metadata
- Authors
- Yang, B., Xie, Y., Guo, M., Rosner, M. H., Yang, H., & Ronco, C.
- Venue
- Clinical Journal of the American Society of Nephrology
- Published
- 2018-04-03
- Volume
- 13
- Issue
- 10
- Pages
- 1605-1611
- ISSN
- 1555-9041 (ISSN-L)
- 1555-905X
- OpenAlex
- W2795549751
- Cited by
- 267
- References
- 36
- FWCI
- 10.39
- Type
- journal article
- Language
- en
- Open access
- green
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- Yang, B., Xie, Y., Guo, M., Rosner, M. H., Yang, H., & Ronco, C. (2018). Nephrotoxicity and Chinese Herbal Medicine. Clinical Journal of the American Society of Nephrology. https://doi.org/10.2215/cjn.11571017
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