Cited by 13Surfactants and Colloidal SystemsTherapeutic Uses of Natural ElementsAdvancements in Transdermal Drug Delivery

THE INVESTIGATION OF THE DEVELOPMENT OF A CREAM COMPOSITION WITH THE SAPROPEL EXTRACT

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Strus, Oksana, Polovko, Natalya, Plaskonis, Yuliya·2018·Asian Journal of Pharmaceutical and Clinical Research

Abstract

Objective: The objective of this research was the development of cream with sapropel extract on the emulsifying base and the investigation of the possibility for cream samples to be in future applied in medicine, cosmetics, and veterinary.Methods: To carry out the research a set of methods (centrifugal, thermal, and potentiometric) to analyze colloidal and thermal stability and determine pH values of the tested samples were used. Organoleptic characteristics of the tested samples and possible signs of physical instability were studied. Rheological properties of the samples were determined on the rotating viscometer. The method of microscopic analysis was carried out to analyze the stability of the emulsion system.Results: The research outcomes revealed that all the prototype samples have thermal and colloid stability, neutral pH value, and consistency that depends on the content of the oil phase and the emulsifying mixture. The samples, containing 15% of Vaseline oil and 4% and 6% of emulsifier no. 1, have low viscosity indexes, and the sample with 10% of emulsifier has a rather dense consistency. The samples containing 20% of oil phase possess unsatisfactory organoleptic properties. Since the sample with 4% of emulsifier possessed low rates of viscosity and phase separation occurred during its storage.Microscopic studies have shown that the sample containing 6% of emulsifier no. 1 exhibits monodisperse and a uniform roundness of drops that indicates the stability of the system.Conclusion: The outcome of the research is the development of the composition of the cream with sapropel extract with the emulsifying base containing 15% of corn oil, 6% of emulsifier no. 1, and 1% of Cetostearyl alcohol and purified water.

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Crossref · 10.22159/ajpcr.2018.v11i7.23575

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  • The stratum corneum's ability to shield the skin against some irritants, such as allergies, chemotherapeutics, or dermatitis, may not be sufficient.

    “The stratum corneum's ability to shield the skin against some irritants, such as allergies, chemotherapeutics, or dermatitis, may not be sufficient [78].”

    From AN OVERVIEW OF NEW TRENDS IN THE COSMETICS INDUSTRY (2025) · cites this paper as [78]

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References 6 · Cited by 13

Authors
Strus, O., Polovko, N., & Plaskonis, Y.
Affiliations
  • Danylo Halytsky Lviv National Medical University (UA)
  • National University of Pharmacy (UA)
Venue
Asian Journal of Pharmaceutical and Clinical Research
Published
2018-07-07
Volume
11
Issue
7
Pages
147
ISSN
  • 0974-2441 (ISSN-L)
  • 2455-3891
OpenAlex
W2843245997
Cited by
13
References
6
Citations by year
2025: 3 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 2
FWCI
0.61
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
Asian Journal of Pharmaceutical and Clinical Research (publishedVersion, cc-by-nc)
Topics
  • Physical Sciences › Chemistry › Organic Chemistry › Surfactants and Colloidal Systems
  • Health Sciences › Health Professions › Complementary and Manual Therapy › Therapeutic Uses of Natural Elements
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
Keywords
cream formulation, emulsion stability, thermal stability, colloidal stability, rheological properties, viscosity, cetostearyl alcohol, corn oil, vaseline oil, phase separation, cosmetic formulation

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