The DOI matches its Crossref record; 124 of the 124 references it cites were found in a registry or an index.
Variation in CYP1A2 Activity and its Clinical Implications: Influence of Environmental Factors and Genetic Polymorphisms
Abstract
CYP1A2 is involved in the metabolism of several widely used drugs and endogenous compounds, and in the activation of procarcinogens. Both genetic and environmental factors influence the activity of this enzyme. The current knowledge regarding factors influencing the activity of CYP1A2 is summarized in this review. Substrates, inhibitors and inducers of CYP1A2 activity, as well as phenotyping probes, are discussed. The functional significance and clinical importance of CYP1A2 gene polymorphisms are reviewed and interethnic differences in the distribution of CYP1A2 variant alleles and haplotypes are summarized. Finally, future perspectives for the possible clinical applications of CYP1A2 genotyping are discussed.
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Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver
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Cited by
Zanger, U. M., & Schwab, M. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.12.007 · Cited by 4,169
Cytochrome P450 variations in different ethnic populations
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Cornelis, M. C., Kacprowski, T., Menni, C., Gustafsson, S., Pivin, E., Adamski, J., Artati, A., Eap, C. B., Ehret, G., Friedrich, N., et al. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw334 · Cited by 175
Blood biomarkers and treatment response in major depression
Mora, C., Zonca, V., Riva, M. A., & Cattaneo, A. (2018) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2018.1470927 · Cited by 107
Metadata
- Authors
- Gunes, A., & Dahl, M.-L.
- Venue
- Pharmacogenomics
- Publisher
- Informa UK Limited
- Published
- 2008-05
- Volume
- 9
- Issue
- 5
- Pages
- 625-637
- ISSN
- 1462-2416 (ISSN-L)
- 1744-8042
- OpenAlex
- W2139149616
- Cited by
- 256
- References
- 124
- FWCI
- 9.65
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Variation in CYP1A2 Activity and its Clinical Implications: Influence of Environmental Factors and Genetic Polymorphisms. https://app.cochat.ai/papers/10.2217/14622416.9.5.625
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- Gunes, A., & Dahl, M.-L. (2008). Variation in CYP1A2 Activity and its Clinical Implications: Influence of Environmental Factors and Genetic Polymorphisms. Pharmacogenomics. https://doi.org/10.2217/14622416.9.5.625
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
