Biomarkers in Lung Cancer: From Early Detection to Novel Therapeutics and Decision Making
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A predictive model incorporating clinical parameters, radiologic characteristics of pulmonary nodules, LDCT-derived AI outputs, and liquid biopsy data demonstrated sensitivity of 89.53%, specificity of 81.31%, and an AUC of 0.880 in the training cohort.
“In another prospective investigation, a predictive model incorporating clinical parameters (age and smoking status), radiologic characteristics of pulmonary nodules (including nodule size, number, upper-lobe location, malignant edge features, and subsolid appearance), LDCT-derived AI outputs, and liquid biopsy data demonstrated optimal performance in the training cohort, with a sensitivity of 89.5”
From Artificial Intelligence in Oncologic Thoracic Surgery: Clinical Decision Support and Emerging Applications (2026) · cites this paper as [34]
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Amado, R. G., Wolf, M., Peeters, M., Van Cutsem, E., Siena, S., Freeman, D. J., Juan, T., Sikorski, R., Suggs, S., Radinsky, R., et al. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.14.7116 · Cited by 3,207 · see citing works
Epidermal growth factor receptor mutations in lung cancer
Sharma, S. V., Bell, D. W., Settleman, J., & Haber, D. A. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2088 · Cited by 3,170 · see citing works
Herbst, R. S., Prager, D., Hermann, R., Fehrenbacher, L., Johnson, B. E., Sandler, A., Kris, M. G., Tran, H. T., Klein, P., Li, X., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.02.840 · Cited by 1,490 · see citing works
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Cited by
Sorted by citations
Petrella, F., & Rizzo, S. (2026) · Cancers · doi:10.3390/cancers18020246 · Cited by 10 · see citing works
- Authors
- Scott, A., & Salgia, R.
- Affiliations
- University of Chicago, Department of Medicine, Section of Hematology/Oncology, and University of Chicago Cancer Research Center, 5841 S Maryland Avenue, Chicago, IL60637, USA.
- Venue
- Biomarkers in Medicine
- Publisher
- Informa UK Limited
- Published
- 2008-12
- Volume
- 2
- Issue
- 6
- Pages
- 577-586
- ISSN
- 1752-0363
- 1752-0371
- PMC
- PMC2742385
- Cited by
- 53
- References
- 3
- Language
- en
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