Systemic Immune-Inflammation Index Is A Novel Marker to Predict Functionally Significant Coronary Artery Stenosis
Abstract
Aim: The study aimed to investigate and compare the predictive capacity of a systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) to determine a hemodynamically significant coronary artery stenosis assessed by fractional flow reserve (FFR). Patients & methods: A total of 207 chronic coronary syndrome patients with FFR measurement were enrolled in the study. NLR, PLR and SII levels were calculated. Results: The cut-off value of the SII (620) was associated with 78.4% sensitivity and 64.0% specificity to predict a hemodynamically significant stenosis. SII level independently predicted FFR ≤0.80. Conclusion: SII is an independent predictor of functionally significant coronary stenosis detected by FFR in chronic coronary syndrome patients. SII levels can predict hemodynamically severe obstruction better than NLR and PLR.
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The combination of NLR and PLR revealed the systemic inflammatory index (SII), which is used as a marker of mortality and prognosis in tumors and coronary artery disease.
“The combination of NLR and PLR revealed the systemic inflammatory index (SII). It is used as a marker of mortality and prognosis in tumors and coronary artery disease.5”
From Association Between Mood Disorder Severity, Treatment Response and Systemic Inflammatory Markers: Exploring the Role of NLR, PLR, MLR, and SII (2024) · cites this paper as [5]
The SII index has been investigated as a prognostic factor in cardiovascular disease, cancer, and interstitial lung disease.
“In contrast, the SII index has been investigated as a prognostic factor in cardiovascular disease, cancer, and interstitial lung disease.5,17,18”
From Association Between Mood Disorder Severity, Treatment Response and Systemic Inflammatory Markers: Exploring the Role of NLR, PLR, MLR, and SII (2024) · cites this paper as [5]
Cites
Neutrophil to lymphocyte ratio (NLR) and cardiovascular diseases: an update
Afari, M. E., & Bhat, T. (2016) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.2016.1154788 · Cited by 439 · see citing works
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Dionisie, V., Filip, G. A., Manea, M. C., Movileanu, R. C., Moisa, E., Manea, M., Riga, S., & Ciobanu, A. M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10091924 · Cited by 82 · see citing works
Dadouli, K., Janho, M. B., Hatziefthimiou, A., Voulgaridi, I., Piaha, K., Anagnostopoulos, L., Ntellas, P., Mouchtouri, V. A., Bonotis, K., Christodoulou, N., et al. (2022) · Brain Sciences · doi:10.3390/brainsci12081034 · Cited by 57 · see citing works
Department of Psychiatry, G. U., Kucukkarapinar, M., Erbil, D., Department of Psychiatry, G. U., Keles, İ., Department of Psychiatry, G. U., Karadag, F., & Department of Psychiatry, G. U. (2024) · Psychiatry and Clinical Psychopharmacology · doi:10.5152/pcp.2024.23760 · Cited by 14 · see citing works
- Authors
- Erdoğan, M., Erdöl, M. A., Öztürk, S., & Durmaz, T.
- Affiliations
- Sağlık Bilimleri Üniversitesi (TR)
- Yozgat Bozok Üniversitesi (TR)
- Venue
- Biomarkers in Medicine
- Publisher
- Informa UK Limited
- Published
- 2020-11
- Volume
- 14
- Issue
- 16
- Pages
- 1553-1561
- ISSN
- 1752-0363 (ISSN-L)
- 1752-0371
- OpenAlex
- W3106460787
- Cited by
- 128
- References
- 1
- Citations by year
- 2026: 8 · 2025: 21 · 2024: 28 · 2023: 25 · 2022: 33 · 2021: 13
- FWCI
- 6.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomarkers in Medicine (publishedVersion)
- PubMed (publishedVersion)
- AYBU AVESIS (submittedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Keywords
- systemic immune-inflammation index, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, coronary artery stenosis, stable coronary artery disease, fractional flow reserve, inflammatory markers, risk prediction
- MeSH terms
- Aged, Blood Platelets, Diagnostic Techniques, Cardiovascular, Female, Humans, Inflammation, Lymphocytes, Male, Middle Aged, Neutrophils, Prognosis, Retrospective Studies, Biomarkers, Coronary Angiography, Lymphocyte Count, Coronary Stenosis, Fractional Flow Reserve, Myocardial
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