Structure and Immunomodulatory Activity of a Recombinant Mucus-Binding Protein of Lactobacillus Acidophilus
Abstract
AIM: The role of mucus-binding protein (MUB) on the adhesion activity and immunomodulatory effect of Lactobacillus acidophilus. MATERIALS & METHODS: The current research mainly focuses on the adhesion and immune function of MUB from L. acidophilus. The structural characteristics and adhesion properties of MUB were analyzed in the intestinal cell models. RESULTS: MUB can promote the aggregation and formation of a membrane-like morphology in L. acidophilus, which could increase the survival rate of L. acidophilus in gastrointestinal tract (GIT). Furthermore, MUB could trigger immune regulation and intestinal protection through the Toll-like receptor 4 (TLR4) signaling pathway and inhibit the activation of mitogen-activated protein kinase (MAPK) signaling pathway. CONCLUSION: MUB of L. acidophilus is an important component involved in bacterial-mucus interactions and immunomodulatory effect in gastrointestinal tract.
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Mucus-binding protein has a signal peptide and ten MucBP domains.
“Mucus-binding protein has a signal peptide and ten MucBP (MUCin-Binding Protein) domain which is found in a wide variety of bacterial proteins, in several reports (Singh et al., 2018; Xiong et al., 2018).”
From Adhesion and Colonization of the Probiotic Lactobacillus plantarum HC-2 in the Intestine of Litopenaeus Vannamei Are Associated With Bacterial Surface Proteins (2022) · cites this paper as Xiong et al., 2018
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References 43 · Cited by 20
- Authors
- Xiong, R., Pan, D., Wu, Z., Guo, Y., Zeng, X., & Lian, L.
- Affiliations
- Ningbo University (CN)
- Nanjing Normal University (CN)
- Ningbo Dairy Group, Ningbo, 315211, Zhejiang, PR China
- Venue
- Future Microbiology
- Publisher
- Informa UK Limited
- Published
- 2018-12
- Volume
- 13
- Issue
- 16
- Pages
- 1731-1743
- ISSN
- 1746-0913 (ISSN-L)
- 1746-0921
- OpenAlex
- W2905272931
- Cited by
- 20
- References
- 43
- Citations by year
- 2025: 4 · 2024: 5 · 2023: 3 · 2022: 4 · 2020: 3 · 2019: 1
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Future Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Science Funding of China (31601487, 31671869, 31471598)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Lactobacillus acidophilus, bacterial adhesion, immunomodulation, TLR4 signaling, MAPK signaling, intestinal protection, probiotic survival in gastrointestinal tract, protein structure
- MeSH terms
- RAW 264.7 Cells, Animals, Bacterial Adhesion, Bacterial Proteins, Carrier Proteins, Genes, Bacterial, Humans, Immunologic Factors, Intestinal Mucosa, Lactobacillus acidophilus, Mucus, Protein Conformation, Recombinant Proteins, Signal Transduction, Gene Expression Regulation, Bacterial, Caco-2 Cells, Probiotics, Mitogen-Activated Protein Kinases, Gastrointestinal Tract, Toll-Like Receptor 4, Mice, Microbial Interactions, Immunomodulation
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