New Insights into the Interaction of Mycobacterium Tuberculosis and Human Macrophages
Abstract
Mycobacterium tuberculosis is a facultative intracellular pathogen. It infects macrophages where it avoids elimination by interfering with host defense mechanisms. Until recently, it was assumed that the acidification of phagosomes is the major strategy of macrophages to eliminate M. tuberculosis. However, there is emerging evidence demonstrating that human macrophages are equipped with additional antimicrobial effector functions. Specifically, autophagy, efferocytosis and antimicrobial peptides have been identified as mechanisms to restrict mycobacterial proliferation. Here we review recent findings on effector functions of human macrophages and mechanisms of the pathogen to interfere with them.
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The fight of the host against the pathogen in M. tuberculosis infection involves several levels including containment of the microbe, generation of radicals and a hostile acidic environment, deprivation from essential nutrients, formation of anti-mycobacterial peptides and cytokines, and cell damage and suicidal activities of macrophages and PMNs such as autophagy, necroptosis, or efferocytosis to
“the fight of the host against the pathogen in M. tuberculosis infection involves several levels including containment of the microbe, generation of radicals and a hostile, acidic environment, deprivation from essential nutrients, formation of anti-mycobacterial peptides and cytokines which strengthen host responses by attracting other immune cells, down to cell damage and suicidal activities of MO”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [4]
Part of the anti-mycobacterial activity of cathelicidin is traced to induction of autophagy.
“as well as to induction of autophagy (4, 85).”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [4]
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References 115 · Cited by 47
- Authors
- Bruns, H., & Stenger, S.
- Affiliations
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- University Hospital Ulm (DE)
- Venue
- Future Microbiology
- Publisher
- Informa UK Limited
- Published
- 2014-03
- Volume
- 9
- Issue
- 3
- Pages
- 327-341
- ISSN
- 1746-0913 (ISSN-L)
- 1746-0921
- OpenAlex
- W2076874179
- Cited by
- 47
- References
- 115
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 6 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 4 · 2015: 9
- FWCI
- 0.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Future Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Health Sciences › Medicine › Epidemiology › Mycobacterium research and diagnosis
- Keywords
- Mycobacterium tuberculosis, human macrophages, host-pathogen interaction, phagosome acidification, autophagy, efferocytosis, antimicrobial peptides, intracellular bacterial infection, host defense evasion
- MeSH terms
- Autophagy, Humans, Immunity, Macrophages, Mycobacterium tuberculosis, Phagocytosis, Tuberculosis, Vitamin D, Reactive Oxygen Species, Antimicrobial Cationic Peptides, Host-Pathogen Interactions
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