Ultra-small solid archaeolipid nanoparticles for active targeting to macrophages of the inflamed mucosa
Open accessAbstract
AIM: Develop nanoparticulate agents for oral targeted delivery of dexamethasone (Dex) to macrophages of inflamed mucosa. MATERIALS & METHODS: Solid archaeolipid nanoparticles (SAN-Dex) (compritol/Halorubrum tebenquichense polar archaeolipids/soybean phosphatidylcholine/Tween-80 4; 0.9; 0.3; 3% w/w) loaded with Dex were prepared. Their mucopenetration, stability under digestion and in vitro anti-inflammatory activity, were determined. RESULTS: Ultra-small SAN-Dex strongly reduced the levels of TNF-α, IL-6 and IL-12 on J774A1 cells stimulated with lipopolysaccharides as compared with free Dex or loaded in ordinary solid lipid nanoparticles-Dex. After in vitro digestion, the anti-inflammatory activity of SAN-Dex was retained, while that of solid lipid nanoparticles-Dex was lost. CONCLUSION: Because of their structural and pharmacodynamic features, SAN-Dex may be suitable for oral targeted delivery to inflamed mucosa.
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Artificial materials such as synthetic liposomes and polylactic acid have been exploited as carriers.
“With the progress of science and technology, artificial materials such as synthetic liposomes and polylactic acid have been exploited as carriers in the last few years.”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [18]
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References 59 · Cited by 35
- Authors
- Higa, L. H., Jerez, H. E., de Farias, M. A., Portugal, R. V., Romero, E. L., & Morilla, M. J.
- Affiliations
- National University of Quilmes (AR)
- Brazilian Nanotechnology National Laboratory, CNPEM, Caixa Postal 6192, CEP 13.083–970CampinasSão PauloBrazil
- Brazilian Center for Research in Energy and Materials (BR)
- Nanomedicine Research Program, Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Roque Saenz Peña 352, BernalB1876BXD, Argentina
- Venue
- Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2017-04-27
- Volume
- 12
- Issue
- 10
- Pages
- 1165-1175
- ISSN
- 1743-5889 (ISSN-L)
- 1748-6963
- OpenAlex
- W2609885834
- Cited by
- 35
- References
- 59
- Citations by year
- 2025: 5 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 6 · 2017: 1
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by-nc-sa
- Locations
- Nanomedicine (publishedVersion)
- PubMed (publishedVersion)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
- Funders
- Laboratório Nacional de Nanotecnologia
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- dexamethasone, oral drug delivery, macrophages, targeted drug delivery, solid lipid nanoparticles, anti-inflammatory activity, TNF-α, interleukin-6, IL-12, lipopolysaccharide, in vitro digestion stability, mucosal penetration
- MeSH terms
- Animals, Anti-Inflammatory Agents, Cell Line, Dexamethasone, Humans, Inflammation, Intestinal Mucosa, Lipids, Lipopolysaccharides, Macrophages, Tumor Necrosis Factor-alpha, Interleukin-6, Drug Delivery Systems, Interleukin-12, Caco-2 Cells, Mice, Nanoparticles, Halorubrum
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