The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Stem/Progenitor Cells from Inflamed Human Dental Pulp Retain Tissue Regeneration Potential
Open accessAbstract
BACKGROUND: Potent stem/progenitor cells have been isolated from normal human dental pulps termed dental pulp stem cells (DPSCs). However, it is unknown whether these cells exist in inflamed pulps (IPs). AIMS: To determine whether DPSCs can be identified and isolated from IPs; and if they can be successfully cultured, whether they retain tissue regeneration potential in vivo. MATERIALS & METHODS: DPSCs from freshly collected normal pulps (NPs) and IPs were characterized in vitro and their tissue regeneration potential tested using an in vivo study model. RESULTS: The immunohistochemical analysis showed that IPs expressed higher levels of mesenchymal stem cell markers STRO-1, CD90, CD105 and CD146 compared with NPs (p < 0.05). Flow cytometry analysis showed that DPSCs from both NPs and IPs expressed moderate to high levels of CD146, stage-specific embryonic antigen-4, CD73 and CD166. Total population doubling of DPSCs-IPs (44.6 + or - 2.9) was lower than that of DPSCs-NPs (58.9 + or - 2.5) (p < 0.05), and DPSCs-IPs appeared to have a decreased osteo/dentinogenic potential compared with DPSCs-NPs based on the mineral deposition in cultures. Nonetheless, DPSCs-IPs formed pulp/dentin complexes similar to DPSCs-NPs when transplanted into immunocompromised mice. CONCLUSION: DPSCs-IPs can be isolated and their mesenchymal stem cell marker profiles are similar to those from NPs. Although some stem cell properties of DPSCs-IPs were altered, cells from some samples remained potent in tissue regeneration in vivo.
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Dominici, M., Le Blanc, K., Mueller, I., Slaper-Cortenbach, I., Marini, F. C., Krause, D. S., Deans, R. J., Keating, A., Prockop, D. J., & Horwitz, E. M. (2006) · Cytotherapy · doi:10.1080/14653240600855905 · Cited by 17,766
Inhibition of Osteoblast Differentiation by Tumor Necrosis Factor-α*
Gilbert, L., He, X., Farmer, P., Boden, S., Kozlowski, M., Rubin, J., & Nanes, M. S. (2000) · Endocrinology · doi:10.1210/endo.141.11.7739 · Cited by 555
High glucose-induced replicative senescence: point of no return and effect of telomerase
Blazer, S., Khankin, E., Segev, Y., Ofir, R., Yalon-Hacohen, M., Kra-Oz, Z., Gottfried, Y., Larisch, S., & Skorecki, K. L. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00818-5 · Cited by 113
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Concise Review: The Surface Markers and Identity of Human Mesenchymal Stem Cells
Lv, F.-J., Tuan, R. S., Cheung, K. M. C., & Leung, V. Y. L. (2014) · Stem Cells · doi:10.1002/stem.1681 · Cited by 984
Self-citationRegenerative endodontics: a comprehensive review
Kim, S. G., Malek, M., Sigurdsson, A., Lin, L. M., & Kahler, B. (2018) · International Endodontic Journal · doi:10.1111/iej.12954 · Cited by 523
Stem cell-delivery therapeutics for periodontal tissue regeneration
Chen, F.-M., Sun, H.-H., Lu, H., & Yu, Q. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.05.048 · Cited by 324
Metadata
- Authors
- Alongi, D. J., Yamaza, T., Song, Y., Fouad, A. F., Romberg, E. E., Shi, S., Tuan, R. S., & Huang, G. T.-J.
- Venue
- Regenerative Medicine
- Publisher
- Informa UK Limited
- Published
- 2010-07
- Volume
- 5
- Issue
- 4
- Pages
- 617-631
- ISSN
- 1746-0751 (ISSN-L)
- 1746-076X
- OpenAlex
- W2116085460
- Cited by
- 283
- References
- 3
- FWCI
- 5.96
- Type
- journal article
- Language
- en
- Open access
- green
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- Alongi, D. J., Yamaza, T., Song, Y., Fouad, A. F., Romberg, E. E., Shi, S., Tuan, R. S., & Huang, G. T.-J. (2010). Stem/Progenitor Cells from Inflamed Human Dental Pulp Retain Tissue Regeneration Potential. Regenerative Medicine. https://doi.org/10.2217/rme.10.30
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